Alterations of calcium homoeostasis in cultured rat astrocytes evoked by bioactive sphingolipids

In the brain, alterations in sphingolipid metabolism contribute to several neurological disorders; however, their effect on astrocytes is largely unknown. Here, we identified bioactive sphingolipids that affect intracellular free calcium concentration ([Ca2+]i), mobility of peptidergic secretory vesicles, signalling pathways involved in alterations of calcium homoeostasis and explored the relationship between the stimulus‐evoked increase in [Ca2+]i and attenuation of vesicle mobility.

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