On the inhibition of histone deacetylase 8.

[1]  Adriano Martinelli,et al.  Docking of Hydroxamic Acids into HDAC1 and HDAC8: A Rationalization of Activity Trends and Selectivities , 2009, J. Chem. Inf. Model..

[2]  R. V. van Breemen,et al.  Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors. , 2009, Journal of medicinal chemistry.

[3]  C. Fierke,et al.  Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. , 2008, Biochemistry.

[4]  Christopher B. Harrison,et al.  Structural origin of selectivity in class II-selective histone deacetylase inhibitors. , 2008, Journal of medicinal chemistry.

[5]  M. Binaschi,et al.  Histone deacetylase inhibitors: from bench to clinic. , 2008, Journal of medicinal chemistry.

[6]  Joshua Close,et al.  Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). , 2008, Bioorganic & medicinal chemistry letters.

[7]  R. Mosley,et al.  Benzo[b]thiophene-based histone deacetylase inhibitors. , 2007, Bioorganic & medicinal chemistry letters.

[8]  Eric Verdin,et al.  Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. , 2007, Bioorganic & medicinal chemistry letters.

[9]  Matthew P. Repasky,et al.  Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. , 2006, Journal of medicinal chemistry.

[10]  Satoshi Inoue,et al.  Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. , 2006, Cancer research.

[11]  R. Ficner,et al.  Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases. , 2006, Journal of biotechnology.

[12]  R. Ficner,et al.  Crystal structure of a bacterial class 2 histone deacetylase homologue. , 2005, Journal of molecular biology.

[13]  O. Wiest,et al.  Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases. , 2005, Journal of medicinal chemistry.

[14]  K. Bhalla.  Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  Silvio Massa,et al.  Histone deacetylation in epigenetics: An attractive target for anticancer therapy , 2005, Medicinal research reviews.

[16]  Xiang-Jiao Yang,et al.  Class II Histone Deacetylases: from Sequence to Function, Regulation, and Clinical Implication , 2005, Molecular and Cellular Biology.

[17]  L. Altucci,et al.  Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. , 2005, Journal of medicinal chemistry.

[18]  M. Esteller,et al.  Histone deacetylase inhibitors: Understanding a new wave of anticancer agents , 2004, International journal of cancer.

[19]  A. Lund,et al.  Epigenetics and cancer. , 2004, Genes & development.

[20]  Sang Gyun Kim,et al.  Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation , 2004, Clinical Cancer Research.

[21]  Junmei Wang,et al.  Development and testing of a general amber force field , 2004, J. Comput. Chem..

[22]  J. R. Somoza,et al.  Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. , 2004, Structure.

[23]  O. Wiest,et al.  On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors. , 2004, Journal of medicinal chemistry.

[24]  J. Vance,et al.  The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress , 2003, Cell.

[25]  C. Tatko,et al.  The geometry and efficacy of cation–π interactions in a diagonal position of a designed β‐hairpin , 2003 .

[26]  P. Marks,et al.  Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors , 1999, Nature.

[27]  Peter A. Kollman,et al.  Application of the RESP Methodology in the Parametrization of Organic Solvents , 1998 .

[28]  T. Darden,et al.  A smooth particle mesh Ewald method , 1995 .

[29]  D. Yarkony,et al.  Modern Electronic Structure Theory: Part I , 1995 .

[30]  H. G. Petersen.  Accuracy and efficiency of the particle mesh Ewald method , 1995 .

[31]  P. Kollman,et al.  A well-behaved electrostatic potential-based method using charge restraints for deriving atomic char , 1993 .

[32]  B. Brooks,et al.  An analysis of the accuracy of Langevin and molecular dynamics algorithms , 1988 .

[33]  W. L. Jorgensen,et al.  Comparison of simple potential functions for simulating liquid water , 1983 .

[34]  G. Ciccotti,et al.  Numerical Integration of the Cartesian Equations of Motion of a System with Constraints: Molecular Dynamics of n-Alkanes , 1977 .