Integration of DNA and graphene oxide for the construction of various advanced logic circuits.

Multiple advanced logic circuits including the full-adder, full-subtract and majority logic gate have been successfully realized on a DNA/GO platform for the first time. All the logic gates were implemented in an enzyme-free condition. The investigation provides a wider field of vision towards prototypical DNA-based algebra logical operations and promotes the development of advanced logic circuits.

[1]  V. Víglaský,et al.  Formation of highly ordered multimers in G-quadruplexes. , 2014, Biochemistry.

[2]  Alexander Prokup,et al.  Interfacing synthetic DNA logic operations with protein outputs. , 2014, Angewandte Chemie.

[3]  Stefan Slesazeck,et al.  Functionality-Enhanced Logic Gate Design Enabled by Symmetrical Reconfigurable Silicon Nanowire Transistors , 2015, IEEE Transactions on Nanotechnology.

[4]  Wei Hong,et al.  A resettable and reprogrammable DNA-based security system to identify multiple users with hierarchy. , 2014, ACS nano.

[5]  Dong-Eun Kim,et al.  Fluorescence-based detection of single-nucleotide changes in RNA using graphene oxide and DNAzyme. , 2015, Chemical communications.

[6]  Jiangtao Ren,et al.  Application of DNA machine in amplified DNA detection. , 2014, Chemical communications.

[7]  Xi Chen,et al.  Coupling Two Different Nucleic Acid Circuits in an Enzyme-Free Amplifier , 2012, Molecules.

[8]  Milan N Stojanovic,et al.  Networking particles over distance using oligonucleotide-based devices. , 2007, Journal of the American Chemical Society.

[9]  A. Shanzer,et al.  A molecular full-adder and full-subtractor, an additional step toward a moleculator. , 2006, Journal of the American Chemical Society.

[10]  C. Joachim,et al.  The mathematics of a quantum Hamiltonian computing half adder Boolean logic gate , 2015, Nanotechnology.

[11]  Yong Xia,et al.  DNA-based visual majority logic gate with one-vote veto function , 2015, Chemical science.

[12]  Xiaogang Qu,et al.  Combination of Graphene Oxide and Thiol‐Activated DNA Metallization for Sensitive Fluorescence Turn‐On Detection of Cysteine and Their Use for Logic Gate Operations , 2011 .

[13]  Dmitry M Kolpashchikov,et al.  Molecular logic gates connected through DNA four-way junctions. , 2010, Angewandte Chemie.

[14]  Min Zhang,et al.  A reversible fluorescent DNA logic gate based on graphene oxide and its application for iodide sensing. , 2012, Chemical communications.

[15]  Engin U Akkaya,et al.  Cascading of molecular logic gates for advanced functions: a self-reporting, activatable photosensitizer. , 2013, Angewandte Chemie.

[16]  Junlin Wen,et al.  Concatenated logic circuits based on a three-way DNA junction: a keypad-lock security system with visible readout and an automatic reset function. , 2014, Angewandte Chemie.

[17]  Hailong Li,et al.  Implementation of Arithmetic Functions on a Simple and Universal Molecular Beacon Platform , 2015, Advanced science.

[18]  Zhen Gu,et al.  Furin‐Mediated Sequential Delivery of Anticancer Cytokine and Small‐Molecule Drug Shuttled by Graphene , 2015, Advanced materials.

[19]  Akira Suyama,et al.  A DNA based molecular logic gate capable of a variety of logical operations , 2013, Natural Computing.

[20]  I. Willner,et al.  Logic gates and antisense DNA devices operating on a translator nucleic Acid scaffold. , 2009, ACS nano.

[21]  Andreas Offenhäusser,et al.  An electrochemically transduced XOR logic gate at the molecular level. , 2010, Angewandte Chemie.

[22]  Changtong Wu,et al.  An enzyme-free and DNA-based Feynman gate for logically reversible operation. , 2015, Chemical communications.

[23]  C. Chiang,et al.  Graphene oxide as a chemosensitizer: diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects. , 2015, Biomaterials.

[24]  Simone Severini,et al.  Logic circuits from zero forcing , 2011, Natural Computing.

[25]  Raphael D. Levine,et al.  A full-adder based on reconfigurable DNA-hairpin inputs and DNAzyme computing modules , 2014 .

[26]  J. Tour,et al.  Molecular electronics. Synthesis and testing of components. , 2000, Accounts of chemical research.

[27]  Shaojun Dong,et al.  DNA-based advanced logic circuits for nonarithmetic information processing , 2015 .

[28]  I. Willner,et al.  Multiplexed aptasensors and amplified DNA sensors using functionalized graphene oxide: application for logic gate operations. , 2012, ACS nano.

[29]  E. Wang,et al.  Implementation of half adder and half subtractor with a simple and universal DNA-based platform , 2013 .

[30]  Cuichen Wu,et al.  A logical molecular circuit for programmable and autonomous regulation of protein activity using DNA aptamer-protein interactions. , 2012, Journal of the American Chemical Society.

[31]  Shaojun Dong,et al.  Molecular aptamer beacon tuned DNA strand displacement to transform small molecules into DNA logic outputs. , 2014, Chemical communications.

[32]  Raphael D. Levine,et al.  DNAzyme-based 2:1 and 4:1 multiplexers and 1:2 demultiplexer , 2014 .

[33]  R. Levine,et al.  Molecule-based photonically switched half and full adder. , 2006, The journal of physical chemistry. A.

[34]  Mette D. E. Jepsen,et al.  Construction of a fuzzy and Boolean logic gates based on DNA. , 2015, Small.

[35]  Li Cai,et al.  Magnetic Quantum Cellular Automata-Based Logic Computation Structure: A Full-Adder Study , 2012 .

[36]  J. Fraser Stoddart,et al.  Logic Operations at the Molecular Level. An XOR Gate Based on a Molecular Machine , 1997 .

[37]  Marek Karpinski,et al.  Simulating Threshold Circuits by Majority Circuits , 1998, SIAM J. Comput..

[38]  Yaqing Liu,et al.  Integration of graphene oxide and DNA as a universal platform for multiple arithmetic logic units. , 2014, Chemical communications.

[39]  Kazuo Tanaka,et al.  DNA logic gates. , 2004, Journal of the American Chemical Society.

[40]  Gianaurelio Cuniberti,et al.  Quantum interference based Boolean gates in dangling bond loops on Si(100):H surfaces , 2015, Scientific Reports.

[41]  Karthik Yogendra,et al.  Exploring Spin-Transfer-Torque Devices for Logic Applications , 2015, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems.

[42]  Mark A. Ratner,et al.  Molecular electronics , 2005 .

[43]  Milko E van der Boom,et al.  Redox-active monolayers as a versatile platform for integrating boolean logic gates. , 2008, Angewandte Chemie.

[44]  Yan Du,et al.  A DNA-based and electrochemically transduced keypad lock system with reset function. , 2012, Chemistry.