Synthesis of 5-(7-hydroxyhept-3-enyl)-1,2-dithiolan-3-one 1-oxide, a core functionality of antibiotic leinamycin

[1]  K. Gates Mechanisms of DNA damage by leinamycin. , 2000, Chemical research in toxicology.

[2]  T. Ashizawa,et al.  Synthesis and antitumor activity of novel thioester derivatives of leinamycin. , 1999, Journal of medicinal chemistry.

[3]  T. Ashizawa,et al.  Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups. , 1998, Bioorganic & Medicinal Chemistry Letters.

[4]  K. Ando,et al.  Simple Oxidation of Thiols with Sodium Iodate under Solid–Solution Biphasic Conditions , 1998 .

[5]  K. Gates,et al.  Oxidative DNA Cleavage by the Antitumor Antibiotic Leinamycin and Simple 1,2-Dithiolan-3-one 1-Oxides: Evidence for Thiol-Dependent Conversion of Molecular Oxygen to DNA-Cleaving Oxygen Radicals Mediated by Polysulfides , 1997 .

[6]  A. Asai,et al.  Thiol-independent DNA cleavage by a leinamycin degradation product. , 1997, Bioorganic & medicinal chemistry.

[7]  A. Asai,et al.  Thiol-Mediated DNA Alkylation by the Novel Antitumor Antibiotic Leinamycin , 1996 .

[8]  K. Gates,et al.  1,2-Dithiolan-3-one 1-oxides: a class of thiol-activated DNA-cleaving agents that are structurally related to the natural product leinamycin. , 1996, Biochemistry.

[9]  K. Gates,et al.  Reaction of n-Propanethiol with 3H-1,2-Benzodithiol-3-one 1-Oxide and 5,5-Dimethyl-1,2-dithiolan-3-one 1-Oxide: Studies Related to the Reaction of Antitumor Antibiotic Leinamycin with DNA , 1995 .

[10]  K. Nicolaou,et al.  DNA–Carbohydrate Recognition: Design and Synthesis of an Eight‐Base Sequence‐Selective DNA‐Binding Oligosaccharide , 1995 .

[11]  K. Nicolaou,et al.  Chemical self-replication of palindromic duplex DNA , 1994, Nature.

[12]  N. Hirayama,et al.  Molecular Structure of a Novel Antitumor Antibiotic Leinamycin , 1993 .

[13]  Y. Kanda,et al.  Total synthesis of (+)-leinamycin , 1993 .

[14]  Y. Kanda,et al.  Synthetic studies on leinamycin. A synthesis of the 1-oxo-1,2-dithiolan-3-one moiety , 1992 .

[15]  A. Shuker,et al.  Synthetic approaches towards the novel 1,3-dioxo-1,2-dithiolane moiety in the antitumour antibiotic substance leinamycin , 1992 .

[16]  A. Shuker,et al.  Synthetic studies towards Leinamycin. A concise synthesis of the spiro-fused 1,3-Dioxo-1,2-dithiolane moiety. , 1991 .

[17]  S. Rokita,et al.  Selective modification of DNA controlled by an ionic signal , 1991 .

[18]  K. Asano,et al.  Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation. , 1989, The Journal of antibiotics.

[19]  K. Asano,et al.  DC 107, a novel antitumor antibiotic produced by a Streptomyces sp. , 1989, The Journal of antibiotics.

[20]  B. Condon,et al.  A convenient procedure for the monosilylation of symmetric 1,n-diols , 1986 .

[21]  M. Rathke,et al.  The Horner-Wadsworth-Emmons modification of the Wittig reaction using triethylamine and lithium or magnesium salts , 1985 .

[22]  S. Danishefsky,et al.  A new strategy for the synthesis of spiroketals , 1983 .

[23]  Y. Shimura,et al.  OPTICAL RESOLUTION OF COBALT(III) COMPLEXES via CYCLODEXTRIN INCLUSION COMPOUNDS , 1982 .

[24]  B. Sweetman,et al.  Biologically oriented organic sulfur chemistry. 8. Structure-activity relationships of penicillamine analogs and derivatives. , 1971, Journal of medicinal chemistry.