Hydrophobic Surface Coating Can Reduce Toxicity of Zinc Oxide Nanoparticles to the Marine Copepod Tigriopus japonicus.

Coated zinc oxide nanoparticles (ZnO-NPs) are more commonly applied in commercial products but current risk assessments mostly focus on bare ZnO-NPs. To investigate the impacts of surface coatings, this study examined acute and chronic toxicities of six chemicals, including bare ZnO-NPs, ZnO-NPs with three silane coatings of different hydrophobicity, zinc oxide bulk particles (ZnO-BKs), and zinc ions (Zn-IONs), toward a marine copepod, Tigriopus japonicus. In acute tests, bare ZnO-NPs and hydrophobic ZnO-NPs were less toxic than hydrophilic ZnO-NPs. Analyses of the copepod's antioxidant gene expression suggested that such differences were governed by hydrodynamic size and ion dissolution of the particles, which affected zinc bioaccumulation in copepods. Conversely, all test particles, except the least toxic hydrophobic ZnO-NPs, shared similar chronic toxicity as Zn-IONs because they mostly dissolved into zinc ions at low test concentrations. The metadata analysis, together with our test results, further suggested that the toxicity of coated metal-associated nanoparticles could be predicted by the hydrophobicity and density of their surface coatings. This study evidenced the influence of surface coatings on the physicochemical properties, toxicity, and toxic mechanisms of ZnO-NPs and provided insights into the toxicity prediction of coated nanoparticles from their coating properties to improve their future risk assessment and management.

[1]  G. Zhou,et al.  Sunscreens containing zinc oxide nanoparticles can trigger oxidative stress and toxicity to the marine copepod Tigriopus japonicus. , 2020, Marine pollution bulletin.

[2]  V. Shanmugam,et al.  A review on anti-inflammatory activity of green synthesized zinc oxide nanoparticle: Mechanism-based approach. , 2019, Bioorganic chemistry.

[3]  G. Zhou,et al.  Accidental Spill of Palm Stearin Poses Relatively Short-Term Ecological Risks to a Tropical Coastal Marine Ecosystem , 2019, Environmental Science & Technology.

[4]  Minghua Wang,et al.  Effects of ocean acidification on life parameters and antioxidant system in the marine copepod Tigriopus japonicus. , 2019, Aquatic toxicology.

[5]  Jae-Seong Lee,et al.  Genome-wide identification and expression of the entire 52 glutathione S-transferase (GST) subfamily genes in the Cu2+-exposed marine copepods Tigriopus japonicus and Paracyclopina nana. , 2019, Aquatic toxicology.

[6]  T. Le,et al.  Zinc Oxide Nanoparticle as a Novel Class of Antifungal Agents: Current Advances and Future Perspectives. , 2018, Journal of agricultural and food chemistry.

[7]  Xiangke Wang,et al.  Toxic effects of different types of zinc oxide nanoparticles on algae, plants, invertebrates, vertebrates and microorganisms. , 2018, Chemosphere.

[8]  Racliffe W. S. Lai,et al.  Regulation of engineered nanomaterials: current challenges, insights and future directions , 2018, Environmental Science and Pollution Research.

[9]  Daniel P Russo,et al.  Predicting Nano-Bio Interactions by Integrating Nanoparticle Libraries and Quantitative Nanostructure Activity Relationship Modeling. , 2017, ACS nano.

[10]  A. Djurišić,et al.  Physicochemical characteristics and toxicity of surface-modified zinc oxide nanoparticles to freshwater and marine microalgae , 2017, Scientific Reports.

[11]  N. Jehmlich,et al.  Effects of chronic dietary exposure of zinc oxide nanoparticles on the serum protein profile of juvenile common carp (Cyprinus carpio L.). , 2017, The Science of the total environment.

[12]  Chia-En Hsiung,et al.  Influence of water chemistry on the environmental behaviors of commercial ZnO nanoparticles in various water and wastewater samples. , 2017, Journal of hazardous materials.

[13]  M. Jansen,et al.  The toxicity of zinc oxide nanoparticles to Lemna minor (L.) is predominantly caused by dissolved Zn. , 2016, Aquatic toxicology.

[14]  E. Franceschinis,et al.  In vivo exposure of the marine clam Ruditapes philippinarum to zinc oxide nanoparticles: responses in gills, digestive gland and haemolymph , 2016, Environmental Science and Pollution Research.

[15]  Eugenia Valsami-Jones,et al.  Earthworm Uptake Routes and Rates of Ionic Zn and ZnO Nanoparticles at Realistic Concentrations, Traced Using Stable Isotope Labeling. , 2016, Environmental science & technology.

[16]  S. Majedi,et al.  Recent advances in the separation and quantification of metallic nanoparticles and ions in the environment , 2016 .

[17]  G. Benvenuto,et al.  Toxicity of nickel in the marine calanoid copepod Acartia tonsa: Nickel chloride versus nanoparticles. , 2016, Aquatic toxicology.

[18]  A. Girigoswami,et al.  Studies on polymer-coated zinc oxide nanoparticles: UV-blocking efficacy and in vivo toxicity. , 2015, Materials science & engineering. C, Materials for biological applications.

[19]  G. Melagraki,et al.  A Risk Assessment Tool for the Virtual Screening of Metal Oxide Nanoparticles through Enalos InSilicoNano Platform. , 2015, Current topics in medicinal chemistry.

[20]  David Rejeski,et al.  Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory , 2015, Beilstein journal of nanotechnology.

[21]  V. Jain,et al.  In vitro toxicity assessment of chitosan oligosaccharide coated iron oxide nanoparticles , 2014, Toxicology reports.

[22]  R. F. Domingos,et al.  The effects of different coatings on zinc oxide nanoparticles and their influence on dissolution and bioaccumulation by the green alga, C. reinhardtii. , 2014, The Science of the total environment.

[23]  R. Schulz,et al.  Heavy metal uptake and toxicity in the presence of titanium dioxide nanoparticles: a factorial approach using Daphnia magna. , 2014, Environmental science & technology.

[24]  E. Carraway,et al.  The induction of biochemical changes in Daphnia magna by CuO and ZnO nanoparticles. , 2014, Aquatic toxicology.

[25]  N. Menguy,et al.  Uncoated and coated ZnO nanoparticle life cycle in synthetic seawater , 2014, Environmental toxicology and chemistry.

[26]  Linhua Hao,et al.  Bioaccumulation and sub-acute toxicity of zinc oxide nanoparticles in juvenile carp (Cyprinus carpio): a comparative study with its bulk counterparts. , 2013, Ecotoxicology and environmental safety.

[27]  V. Stone,et al.  Zinc oxide nanoparticles and monocytes: impact of size, charge and solubility on activation status. , 2013, Toxicology and applied pharmacology.

[28]  A. Ng,et al.  Antibacterial activity of ZnO nanoparticles with a modified surface under ambient illumination , 2012, Nanotechnology.

[29]  I. Corsi,et al.  Toxic effects of engineered nanoparticles in the marine environment: model organisms and molecular approaches. , 2012, Marine environmental research.

[30]  R W Scholz,et al.  Engineered nanomaterials in rivers--exposure scenarios for Switzerland at high spatial and temporal resolution. , 2011, Environmental pollution.

[31]  T. Glenn,et al.  Comparative phototoxicity of nanoparticulate and bulk ZnO to a free-living nematode Caenorhabditis elegans: the importance of illumination mode and primary particle size. , 2011, Environmental pollution.

[32]  Carsten Schilde,et al.  Biological Surface Coating and Molting Inhibition as Mechanisms of TiO2 Nanoparticle Toxicity in Daphnia magna , 2011, PloS one.

[33]  Chris D Vulpe,et al.  Differential gene expression in Daphnia magna suggests distinct modes of action and bioavailability for ZnO nanoparticles and Zn ions. , 2011, Environmental science & technology.

[34]  R. Eichel,et al.  Synthesis, characterization, defect chemistry, and FET properties of microwave-derived nanoscaled zinc oxide , 2010 .

[35]  Da-Ren Chen,et al.  Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.

[36]  Robert Landsiedel,et al.  Acute and chronic effects of nano- and non-nano-scale TiO(2) and ZnO particles on mobility and reproduction of the freshwater invertebrate Daphnia magna. , 2009, Chemosphere.

[37]  T. Xia,et al.  Understanding biophysicochemical interactions at the nano-bio interface. , 2009, Nature materials.

[38]  Baoshan Xing,et al.  Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans. , 2009, Environmental pollution.

[39]  K. Kasemets,et al.  Toxicity of nanoparticles of CuO, ZnO and TiO2 to microalgae Pseudokirchneriella subcapitata. , 2009, The Science of the total environment.

[40]  Y. Xiong,et al.  Photocatalytic activity of polymer-modified ZnO under visible light irradiation. , 2008, Journal of hazardous materials.

[41]  Nanna B. Hartmann,et al.  Ecotoxicity of engineered nanoparticles to aquatic invertebrates: a brief review and recommendations for future toxicity testing , 2008, Ecotoxicology.

[42]  K. Leung,et al.  The copepod Tigriopus: a promising marine model organism for ecotoxicology and environmental genomics. , 2007, Aquatic toxicology.

[43]  Rebecca Klaper,et al.  Behavioral and physiological changes in Daphnia magna when exposed to nanoparticle suspensions (titanium dioxide, nano-C60, and C60HxC70Hx). , 2007, Environmental science & technology.