mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment.
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A. Vezzani | T. Ravizza | Rossella Di Sapia | Mirte Scheper | Eleonora Aronica | Jan Gorter | Jan A. Gorter | Jan A Gorter
[1] Jacqunae Mays,et al. Targeted suppression of mTORC2 reduces seizures across models of epilepsy , 2023, Nature communications.
[2] Lucas E. Flausino,et al. Neuroinflammation: An astrocyte perspective , 2023, Science Translational Medicine.
[3] M. Brodie,et al. Editorial: Epidemiology of epilepsy and seizures , 2023, Frontiers in epidemiology.
[4] A. Orsini,et al. The Influence of Ketogenic Diet on Gut Microbiota: Potential Benefits, Risks and Indications , 2023, Nutrients.
[5] Yuanyuan Yao,et al. Microglia sense and suppress epileptic neuronal hyperexcitability. , 2023, Pharmacological research.
[6] D. Schubert,et al. Excitatory/inhibitory balance in epilepsies and neurodevelopmental disorders: Depolarizing γ‐aminobutyric acid as a common mechanism , 2023, Epilepsia.
[7] S. Baulac,et al. mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy , 2023, Neurobiology of Disease.
[8] K. Kotulska,et al. Effect of mTOR Inhibitors in Epilepsy Treatment in Children with Tuberous Sclerosis Complex Under 2 Years of Age , 2023, Neurology and Therapy.
[9] H. Shiraishi,et al. Efficacy of sirolimus for epileptic seizures in childhood associated with focal cortical dysplasia type II , 2023, Brain and Development.
[10] E. Aronica,et al. Epileptogenesis in tuberous sclerosis complex-related developmental and epileptic encephalopathy , 2023, Brain : a journal of neurology.
[11] A. Vezzani,et al. Neuroimmunology of status epilepticus , 2023, Epilepsy & Behavior.
[12] A. Vezzani,et al. Neuroinflammation microenvironment sharpens seizure circuit , 2023, Neurobiology of Disease.
[13] M. de Curtis,et al. Dendritic spine loss in epileptogenic Type II focal cortical dysplasia: Role of enhanced classical complement pathway activation , 2022, Brain pathology.
[14] J. D. Mills,et al. GABAA receptor function is enhanced by Interleukin-10 in human epileptogenic gangliogliomas and its effect is counteracted by Interleukin-1β , 2022, Scientific Reports.
[15] E. Aronica,et al. Astrocytes in the initiation and progression of epilepsy , 2022, Nature Reviews Neurology.
[16] L. Foley,et al. Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury , 2022, Journal of Neuroinflammation.
[17] J. Bateman,et al. Mechanistic target of rapamycin signaling in human nervous system development and disease , 2022, Frontiers in Molecular Neuroscience.
[18] Dunfang Zhang,et al. Excessive intake of sugar: An accomplice of inflammation , 2022, Frontiers in Immunology.
[19] C. Elger,et al. ‘Hippocampal innate inflammatory gliosis only’ in pharmacoresistant temporal lobe epilepsy , 2022, Brain : a journal of neurology.
[20] S. Schoch,et al. Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy , 2022, PloS one.
[21] M. Fujimoto,et al. Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice , 2022, Neuropharmacology.
[22] Fenghua Chen,et al. The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation , 2022, Frontiers in Immunology.
[23] C. Lei,et al. HMGB1/TLR4 induces autophagy and promotes neuroinflammation after intracerebral hemorrhage , 2022, Brain Research.
[24] F. Ginhoux,et al. Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling , 2022, Nature neuroscience.
[25] F. Cendes,et al. The ILAE consensus classification of focal cortical dysplasia: An update proposed by an ad hoc task force of the ILAE diagnostic methods commission , 2022, Epilepsia.
[26] B. Ueberheide,et al. Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia , 2022, PloS one.
[27] D. Kaufer,et al. Blood–brain barrier dysfunction promotes astrocyte senescence through albumin‐induced TGFβ signaling activation , 2022, bioRxiv.
[28] A. Bordey,et al. Current Review in Basic Science: Animal Models of Focal Cortical Dysplasia and Epilepsy , 2022, Epilepsy currents.
[29] J. Rho,et al. The metabolic basis of epilepsy , 2022, Nature Reviews Neurology.
[30] F. Yousefi,et al. Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy , 2022, Cell biochemistry and function.
[31] Hui Yang,et al. Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII) , 2022, Expert opinion on therapeutic targets.
[32] Mercedes F. Paredes,et al. Amplification of human interneuron progenitors promotes brain tumors and neurological defects , 2022, Science.
[33] A. Kakita,et al. Sirolimus for epileptic seizures associated with focal cortical dysplasia type II , 2022, Annals of clinical and translational neurology.
[34] D. Rotaru,et al. Identifying the temporal electrophysiological and molecular changes that contribute to TSC-associated epileptogenesis , 2021, JCI insight.
[35] Xiaoming Jin,et al. Blocking receptor for advanced glycation end products (RAGE) or toll‐like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice , 2021, Epilepsia.
[36] S. Fernandes,et al. The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging , 2021, Frontiers in Aging.
[37] L. Concha,et al. A systems‐level analysis highlights microglial activation as a modifying factor in common epilepsies , 2021, Neuropathology and applied neurobiology.
[38] S. Cuzzocrea,et al. The inhibition of mammalian target of rapamycin (mTOR) in improving inflammatory response after traumatic brain injury , 2021, Journal of cellular and molecular medicine.
[39] W. Löscher,et al. New approaches for developing multi-targeted drug combinations for disease modification of complex brain disorders. Does epilepsy prevention become a realistic goal? , 2021, Pharmacology & therapeutics.
[40] E. Aronica,et al. Impaired myelin production due to an intrinsic failure of oligodendrocytes in mTORpathies , 2021, Neuropathology and applied neurobiology.
[41] S. Cavalheiro,et al. Everolimus as a possible prenatal treatment of in utero diagnosed subependymal lesions in tuberous sclerosis complex: a case report , 2021, Child's Nervous System.
[42] J. D. Mills,et al. Balloon cells promote immune system activation in focal cortical dysplasia type 2b , 2021, Neuropathology and applied neurobiology.
[43] R. D’Ambrosio,et al. Antiepileptogenesis and disease modification: Progress, challenges, and the path forward—Report of the Preclinical Working Group of the 2018 NINDS‐sponsored antiepileptogenesis and disease modification workshop , 2021, Epilepsia open.
[44] A. Bordey,et al. Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies , 2021, Frontiers in Neuroanatomy.
[45] P. Jat,et al. Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype , 2021, Frontiers in Cell and Developmental Biology.
[46] E. Suleymanova. Behavioral comorbidities of epilepsy and neuroinflammation: Evidence from experimental and clinical studies , 2021, Epilepsy & Behavior.
[47] D. Kaping,et al. mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus , 2021, Journal of neurodevelopmental disorders.
[48] M. de Curtis,et al. A hypothesis for the role of axon demyelination in seizure generation , 2021, Epilepsia.
[49] E. Aronica,et al. Genetic pathogenesis of the epileptogenic lesions in Tuberous Sclerosis Complex: Therapeutic targeting of the mTOR pathway , 2021, Epilepsy & Behavior.
[50] P. Kwan,et al. Inflammation, ictogenesis, and epileptogenesis: An exploration through human disease , 2020, Epilepsia.
[51] S. Danzer,et al. mTOR-driven neural circuit changes initiate an epileptogenic cascade , 2020, Progress in Neurobiology.
[52] S. Rosi,et al. Microglia depletion and cognitive functions after brain injury: From trauma to galactic cosmic ray , 2020, Neuroscience Letters.
[53] D. Spencer,et al. Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice , 2020, Science Translational Medicine.
[54] B. Trapp,et al. Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures. , 2020, Cell reports.
[55] K. Shokat,et al. Brain-restricted mTOR inhibition with binary pharmacology , 2020, bioRxiv.
[56] E. Aronica,et al. Tuberous Sclerosis Complex as Disease Model for Investigating mTOR-Related Gliopathy During Epileptogenesis , 2020, Frontiers in Neurology.
[57] J. D. Mills,et al. Myelin Pathology Beyond White Matter in Tuberous Sclerosis Complex (TSC) Cortical Tubers , 2020, Journal of neuropathology and experimental neurology.
[58] Ukpong B. Eyo,et al. Negative feedback control of neuronal activity by microglia , 2020, Nature.
[59] A. Represa,et al. Progression of Fetal Brain Lesions in Tuberous Sclerosis Complex , 2020, Frontiers in Neuroscience.
[60] D. Henshall,et al. MicroRNAs as regulators of brain function and targets for treatment of epilepsy , 2020, Nature Reviews Neurology.
[61] W. Löscher,et al. Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options , 2020, Pharmacological Reviews.
[62] L. Lagae,et al. Ketogenic diet for the treatment of pediatric epilepsy: review and meta-analysis , 2020, Child's Nervous System.
[63] F. Biagioni,et al. mTOR-Related Cell-Clearing Systems in Epileptic Seizures, an Update , 2020, International journal of molecular sciences.
[64] J. D. Mills,et al. Coding and non-coding transcriptome of mesial temporal lobe epilepsy: Critical role of small non-coding RNAs , 2020, Neurobiology of Disease.
[65] D. Reutens,et al. Complement in the development of post-traumatic epilepsy: prospects for drug repurposing. , 2020, Journal of neurotrauma.
[66] J. Lugo,et al. Therapeutic role of targeting mTOR signaling and neuroinflammation in epilepsy , 2020, Epilepsy Research.
[67] Xing-jie Liang,et al. Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation , 2020, Journal of Neuroinflammation.
[68] W. Löscher,et al. Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both? , 2020, International journal of molecular sciences.
[69] A. Kulkarni,et al. Differential regulation of autophagy during metabolic stress in astrocytes and neurons , 2019, Autophagy.
[70] J. D. Mills,et al. Chronic activation of anti‐oxidant pathways and iron accumulation in epileptogenic malformations , 2019, Neuropathology and applied neurobiology.
[71] S. Duan,et al. mTOR‐mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP , 2019, Glia.
[72] A. Zamani,et al. Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets , 2019, Brain sciences.
[73] P. Crino,et al. GATORopathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations , 2019, Epilepsia.
[74] W. Löscher. Consequences of housing conditions and interindividual diversity in rodent models of acquired epilepsy , 2019, Epilepsia.
[75] E. Aronica,et al. New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives , 2019, Journal of anatomy.
[76] M. Yousefi,et al. mTOR Signaling pathway as a master regulator of memory CD8+ T‐cells, Th17, and NK cells development and their functional properties , 2019, Journal of cellular physiology.
[77] P. V. van Rijen,et al. Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro , 2019, Neuropathology and Applied Neurobiology.
[78] A. Vezzani,et al. Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy , 2019, Nature Reviews Neurology.
[79] Y. Elgersma,et al. Effects of antiepileptic drugs in a new TSC/mTOR‐dependent epilepsy mouse model , 2019, Annals of clinical and translational neurology.
[80] A. Ziegler,et al. Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age – a multicenter retrospective study , 2019, Orphanet Journal of Rare Diseases.
[81] E. Aronica,et al. The Roof is Leaking and a Storm is Raging: Repairing the Blood–Brain Barrier in the Fight Against Epilepsy , 2019, Epilepsy currents.
[82] C. Howe,et al. Functional deficiency in endogenous interleukin‐1 receptor antagonist in patients with febrile infection‐related epilepsy syndrome , 2019, Annals of neurology.
[83] C. Torres,et al. Astrocyte senescence: Evidence and significance , 2019, Aging cell.
[84] Dipan C. Patel,et al. Neuron–glia interactions in the pathophysiology of epilepsy , 2019, Nature Reviews Neuroscience.
[85] N. Toni,et al. Astrocyte function from information processing to cognition and cognitive impairment , 2019, Nature Neuroscience.
[86] K. Kapur,et al. Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex. , 2019, Pediatric neurology.
[87] R. Dingledine,et al. The COX-2/prostanoid signaling cascades in seizure disorders , 2018, Expert opinion on therapeutic targets.
[88] J. D. Mills,et al. Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence , 2018, Brain pathology.
[89] C. Mao,et al. A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration , 2018, Front. Aging Neurosci..
[90] O. Devinsky,et al. Short-term safety of mTOR inhibitors in infants and very young children with tuberous sclerosis complex (TSC): Multicentre clinical experience. , 2018, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.
[91] J. C. Baayen,et al. Activation of the innate immune system is evident throughout epileptogenesis and is associated with blood‐brain barrier dysfunction and seizure progression , 2018, Epilepsia.
[92] B. Zhang,et al. The specificity and role of microglia in epileptogenesis in mouse models of tuberous sclerosis complex , 2018, Epilepsia.
[93] E. Aronica,et al. Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo — in search of potential anti-epileptogenic strategies for temporal lobe epilepsy , 2018, Journal of Neuroinflammation.
[94] I. Scheffer,et al. Epilepsy , 2018, Nature Reviews Disease Primers.
[95] R. Garbelli,et al. Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature , 2018, Neurobiology of Disease.
[96] Z. Ungvari,et al. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. , 2018, American journal of physiology. Heart and circulatory physiology.
[97] Julia W. Chang,et al. Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy , 2018, Cell reports.
[98] E. Aronica,et al. Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies , 2018, Neuropathology and applied neurobiology.
[99] T. Lucas,et al. Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy , 2018, Annals of neurology.
[100] E. Aronica,et al. mTOR dysregulation and tuberous sclerosis-related epilepsy , 2018, Expert review of neurotherapeutics.
[101] A. Vezzani,et al. Inhibition of monoacylglycerol lipase terminates diazepam‐resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet , 2018, Epilepsia.
[102] R. Dingledine,et al. Commonalities in epileptogenic processes from different acute brain insults: Do they translate? , 2018, Epilepsia.
[103] U. Suter,et al. Myelination and mTOR , 2017, Glia.
[104] A. Vezzani,et al. High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy , 2017, Brain, Behavior, and Immunity.
[105] J. D. Mills,et al. Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment , 2017, Scientific Reports.
[106] D. Prince,et al. TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults , 2017, Scientific Reports.
[107] J. C. Baayen,et al. Increased expression of (immuno)proteasome subunits during epileptogenesis is attenuated by inhibition of the mammalian target of rapamycin pathway , 2017, Epilepsia.
[108] S. Brun,et al. Autophagy in neuroinflammatory diseases. , 2017, Autoimmunity reviews.
[109] W. Löscher,et al. Neuroinflammatory targets and treatments for epilepsy validated in experimental models , 2017, Epilepsia.
[110] D. Reddy,et al. Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy. , 2017, Biochimica et biophysica acta. Molecular basis of disease.
[111] D. Kaufer,et al. Imaging blood–brain barrier dysfunction as a biomarker for epileptogenesis , 2017, Brain : a journal of neurology.
[112] Shumei S. Sun,et al. Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury , 2017, Epilepsia.
[113] F. Yin,et al. Interleukin-1β Plays a Pivotal Role via the PI3K/Akt/mTOR Signaling Pathway in the Chronicity of Mesial Temporal Lobe Epilepsy , 2017, Neuroimmunomodulation.
[114] J. Rho,et al. Ketone Bodies as Anti-Seizure Agents , 2017, Neurochemical Research.
[115] Edouard Hirsch,et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology , 2017, Epilepsia.
[116] David M. Sabatini,et al. mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.
[117] M. Zucchetti,et al. Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy , 2017, Neurobiology of Disease.
[118] J. Jaworski,et al. Molecular neurobiology of mTOR , 2017, Neuroscience.
[119] Ukpong B. Eyo,et al. Microglia–Neuron Communication in Epilepsy , 2017, Glia.
[120] C. Limatola,et al. Functional aspects of early brain development are preserved in tuberous sclerosis complex (TSC) epileptogenic lesions , 2016, Neurobiology of Disease.
[121] Changjuan Wei,et al. Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway , 2016, Journal of Neuroimmunology.
[122] S. Barnett,et al. The multifaceted role of astrocytes in regulating myelination , 2016, Experimental Neurology.
[123] P. V. van Rijen,et al. Dysregulation of the (immuno)proteasome pathway in malformations of cortical development , 2016, Journal of Neuroinflammation.
[124] B. Zhang,et al. Microglial activation during epileptogenesis in a mouse model of tuberous sclerosis complex , 2016, Epilepsia.
[125] E. Aronica,et al. Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA‐derived cell cultures , 2016, Glia.
[126] E. Aronica,et al. Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC) , 2016, Journal of Molecular Neuroscience.
[127] W. Guo,et al. Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex , 2016, Journal of Neuroinflammation.
[128] E. Aronica,et al. Immunity and Inflammation in Epilepsy. , 2016, Cold Spring Harbor perspectives in medicine.
[129] E. Aronica,et al. Blood–brain barrier leakage after status epilepticus in rapamycin‐treated rats II: Potential mechanisms , 2016, Epilepsia.
[130] E. Aronica,et al. Blood–brain barrier leakage after status epilepticus in rapamycin‐treated rats I: Magnetic resonance imaging , 2016, Epilepsia.
[131] P. Kloetzel,et al. The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy , 2015, Brain, Behavior, and Immunity.
[132] C. Limatola,et al. GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis , 2015, Neurobiology of Disease.
[133] P. Marin,et al. mTOR in Brain Physiology and Pathologies. , 2015, Physiological reviews.
[134] Kosuke Tomimatsu,et al. Translating the effects of mTOR on secretory senescence , 2015, Nature Cell Biology.
[135] T. Weichhart,et al. Regulation of innate immune cell function by mTOR , 2015, Nature Reviews Immunology.
[136] A. Vezzani,et al. Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability , 2015, Neuropharmacology.
[137] N. Rensing,et al. Inflammatory mechanisms contribute to the neurological manifestations of tuberous sclerosis complex , 2015, Neurobiology of Disease.
[138] J. Rubenstein,et al. The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles. , 2015, Cell reports.
[139] J. Schramm,et al. Astrocyte uncoupling as a cause of human temporal lobe epilepsy. , 2015, Brain : a journal of neurology.
[140] Seok-Gu Kang,et al. Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy , 2015, Nature Medicine.
[141] E. Aronica,et al. Blood-brain barrier dysfunction, seizures and epilepsy. , 2015, Seminars in cell & developmental biology.
[142] R. Dingledine,et al. Candidate drug targets for prevention or modification of epilepsy. , 2015, Annual review of pharmacology and toxicology.
[143] M. Bianchi,et al. Disulfide-containing high mobility group box-1 promotes N-methyl-D-aspartate receptor function and excitotoxicity by activating Toll-like receptor 4-dependent signaling in hippocampal neurons. , 2014, Antioxidants & redox signaling.
[144] Y. Ben-Ari,et al. Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model , 2014, Nature Communications.
[145] A. Coppola,et al. Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies , 2014, Acta neuropathologica communications.
[146] U. Heinemann,et al. Losartan prevents acquired epilepsy via TGF‐β signaling suppression , 2014, Annals of neurology.
[147] Seyedeh-Atiyeh Afjei,et al. Brain inflammation induces post-synaptic changes during early synapse formation in adult-born hippocampal neurons , 2013, Experimental Neurology.
[148] J. Sandkühler,et al. Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity , 2013, Nature Reviews Neuroscience.
[149] S. Cichon,et al. TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue , 2013, Seizure.
[150] Aaron J. Johnson,et al. Theiler’s murine encephalomyelitis virus as an experimental model system to study the mechanism of blood–brain barrier disruption , 2013, Journal of NeuroVirology.
[151] E. Powell. Interneuron Development and Epilepsy: Early Genetic Defects Cause Long-Term Consequences in Seizures and Susceptibility , 2013, Epilepsy currents.
[152] W. Harkness,et al. mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis , 2013, Acta Neuropathologica.
[153] D. Brody,et al. Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury , 2013, PloS one.
[154] Bernardo L. Sabatini,et al. Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis , 2013, Neuron.
[155] Ben A. Barres,et al. Emerging roles of astrocytes in neural circuit development , 2013, Nature Reviews Neuroscience.
[156] A. Anderson,et al. Rapamycin Reverses Status Epilepticus-Induced Memory Deficits and Dendritic Damage , 2013, PloS one.
[157] D. Feinstein,et al. mTOR kinase, a key player in the regulation of glial functions: Relevance for the therapy of multiple sclerosis , 2013, Glia.
[158] M. Wong. Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases , 2013, Biomedical journal.
[159] R. Sankar,et al. Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain , 2013, Journal of Neuroinflammation.
[160] P. Crino,et al. The TARC/sICAM5 Ratio in Patient Plasma is a Candidate Biomarker for Drug Resistant Epilepsy , 2013, Front. Neur..
[161] E. Aronica,et al. Fetal Brain Lesions in Tuberous Sclerosis Complex: TORC1 Activation and Inflammation , 2013, Brain pathology.
[162] A. Vezzani,et al. Long‐lasting pro‐ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology , 2012, Epilepsia.
[163] A. A. Kan,et al. Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines , 2012, Journal of Neuroinflammation.
[164] E. Nagelhus,et al. Aquaporin‐4 and epilepsy , 2012, Glia.
[165] Jan A Gorter,et al. Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target , 2012, Epilepsia.
[166] Charles B. Mikell,et al. The mTOR pathway is activated in glial cells in mesial temporal sclerosis , 2012, Epilepsia.
[167] K. Lukasiuk,et al. Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy , 2012, Neuroscience Letters.
[168] Q. Pittman,et al. Cytokines and brain excitability , 2012, Frontiers in Neuroendocrinology.
[169] A. Vezzani,et al. IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence , 2011, Neurobiology of Disease.
[170] T. Bártfai,et al. IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures , 2011, Brain, Behavior, and Immunity.
[171] P. V. van Rijen,et al. Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. , 2011, Brain : a journal of neurology.
[172] Kelvin A. Yamada,et al. The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway , 2011, Epilepsia.
[173] D. Feinstein,et al. The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes , 2011, Journal of Neuroinflammation.
[174] Yunfei Huang,et al. Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy , 2010, Neurobiology of Disease.
[175] P. V. van Rijen,et al. Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias , 2010, Epilepsia.
[176] L. Zeng,et al. Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): A double-edged sword? , 2010, Cell cycle.
[177] A. McAllister,et al. Novel Roles for Immune Molecules in Neural Development: Implications for Neurodevelopmental Disorders , 2010, Front. Syn. Neurosci..
[178] E. Aronica,et al. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures , 2010, Nature Medicine.
[179] T. Kilpatrick,et al. Role of Cytokines as Mediators and Regulators of Microglial Activity in Inflammatory Demyelination of the CNS , 2010, NeuroMolecular Medicine.
[180] T. McMorrow,et al. Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression. , 2010, American journal of physiology. Renal physiology.
[181] M. Wainwright,et al. Albumin activates astrocytes and microglia through mitogen-activated protein kinase pathways , 2010, Brain Research.
[182] P. V. van Rijen,et al. Gene Expression Analysis of Tuberous Sclerosis Complex Cortical Tubers Reveals Increased Expression of Adhesion and Inflammatory Factors , 2009, Brain pathology.
[183] H. Scharfman,et al. Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy , 2009, Epilepsy Research.
[184] A. Thomson,et al. Immunoregulatory functions of mTOR inhibition , 2009, Nature Reviews Immunology.
[185] C. Stafstrom,et al. Anticonvulsant and antiepileptic actions of 2‐deoxy‐D‐glucose in epilepsy models , 2009, Annals of neurology.
[186] T. Bártfai,et al. A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta. , 2008, Brain : a journal of neurology.
[187] D. Gutmann,et al. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex , 2008, Annals of neurology.
[188] L. Kaczmarek,et al. Important role of matrix metalloproteinase 9 in epileptogenesis , 2008, The Journal of cell biology.
[189] Charles B. Mikell,et al. Tuberous sclerosis: A primary pathology of astrocytes? , 2008, Epilepsia.
[190] E. Aronica,et al. Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex , 2008, Epilepsy Research.
[191] Eleonora Aronica,et al. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy , 2008, Neurobiology of Disease.
[192] John D. Lambris,et al. The Classical Complement Cascade Mediates CNS Synapse Elimination , 2007, Cell.
[193] Lewis C. Cantley,et al. AKT/PKB Signaling: Navigating Downstream , 2007, Cell.
[194] F. L. D. Silva,et al. Complement activation in experimental and human temporal lobe epilepsy , 2007, Neurobiology of Disease.
[195] Y. Jan,et al. Activity- and mTOR-Dependent Suppression of Kv1.1 Channel mRNA Translation in Dendrites , 2006, Science.
[196] E. Aronica,et al. The IL-1β system in epilepsy-associated malformations of cortical development , 2006, Neurobiology of Disease.
[197] P. Crino,et al. Epileptogenesis and Reduced Inward Rectifier Potassium Current in Tuberous Sclerosis Complex‐1–Deficient Astrocytes , 2005, Epilepsia.
[198] Tallie Z. Baram,et al. The role of inflammation in epilepsy , 2011, Nature Reviews Neurology.