Pyramidal and chiral groupings of gold nanocrystals assembled using DNA scaffolds.

Nanostructures constructed from metal and semiconductor nanocrystals conjugated to and organized by DNA are an emerging class of materials with collective optical properties. We created discrete pyramids of DNA with gold nanocrystals at the tips. By taking small-angle X-ray scattering measurements from solutions of these pyramids, we confirmed that this pyramidal geometry creates structures which are more rigid in solution than linear DNA. We then took advantage of the tetrahedral symmetry to demonstrate construction of chiral nanostructures.

[1]  J. Alexander Liddle,et al.  Lithographically directed self-assembly of nanostructures , 2004 .

[2]  David R. Smith,et al.  Reconfigurable core-satellite nanoassemblies as molecularly-driven plasmonic switches. , 2008, Nano letters.

[3]  A Paul Alivisatos,et al.  Two-dimensional nanoparticle arrays show the organizational power of robust DNA motifs. , 2006, Nano letters.

[4]  N. Seeman,et al.  Ligation of DNA Triangles Containing Double Crossover Molecules , 1998 .

[5]  William M. Shih,et al.  A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron , 2004, Nature.

[6]  N. Seeman.  DNA in a material world , 2003, Nature.

[7]  A Paul Alivisatos,et al.  DNA-Based Assembly of Gold Nanocrystals. , 1999, Angewandte Chemie.

[8]  J. SantaLucia,et al.  A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Russell P. Goodman,et al.  Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication , 2005, Science.

[10]  A Paul Alivisatos,et al.  Use of plasmon coupling to reveal the dynamics of DNA bending and cleavage by single EcoRV restriction enzymes , 2006, Proceedings of the National Academy of Sciences.

[11]  Peter Nordlander,et al.  Plasmon modes of nanosphere trimers and quadrumers. , 2006, The journal of physical chemistry. B.

[12]  Russell P. Goodman,et al.  A self-assembled DNA bipyramid. , 2007, Journal of the American Chemical Society.

[13]  Russell P. Goodman,et al.  Reconfigurable, braced, three-dimensional DNA nanostructures. , 2008, Nature nanotechnology.

[14]  E. Winfree,et al.  Algorithmic Self-Assembly of DNA Sierpinski Triangles , 2004, PLoS biology.

[15]  Dmitri I. Svergun,et al.  Determination of the regularization parameter in indirect-transform methods using perceptual criteria , 1992 .

[16]  Peter Nordlander,et al.  Plasmonic nanostructures: artificial molecules. , 2007, Accounts of chemical research.

[17]  P. Schultz,et al.  Organization of 'nanocrystal molecules' using DNA , 1996, Nature.

[18]  A Paul Alivisatos,et al.  Discrete nanostructures of quantum dots/Au with DNA. , 2004, Journal of the American Chemical Society.

[19]  Christine M. Micheel,et al.  Electrophoretic Isolation of Discrete Au Nanocrystal/DNA Conjugates , 2001 .

[20]  D. Pine,et al.  Chiral colloidal clusters , 2008, Nature.

[21]  N. Seeman,et al.  Synthesis from DNA of a molecule with the connectivity of a cube , 1991, Nature.

[22]  Faisal A. Aldaye,et al.  Sequential self-assembly of a DNA hexagon as a template for the organization of gold nanoparticles. , 2006, Angewandte Chemie.

[23]  A Paul Alivisatos,et al.  Enzymatic ligation creates discrete multinanoparticle building blocks for self-assembly. , 2008, Journal of the American Chemical Society.

[24]  N. Seeman,et al.  Construction of a DNA-Truncated Octahedron , 1994 .

[25]  J. Storhoff,et al.  A DNA-based method for rationally assembling nanoparticles into macroscopic materials , 1996, Nature.

[26]  A. Alivisatos,et al.  Isolation of discrete nanoparticle-DNA conjugates for plasmonic applications. , 2008, Nano letters.

[27]  Christine M. Micheel,et al.  Directed assembly of discrete gold nanoparticle groupings using branched DNA scaffolds , 2004 .