The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology.

I. Introduction II. The Regulation of Thyroid Function in Normal Pregnancy A. The thyroid hormone transport proteins B. The thyroid hormones 1. Total thyroid hormones 2. Free thyroid hormones 3. Peripheral metabolism of thyroid hormones C. The serum levels of thyroglobulin (TG) D. The metabolism of iodine E. The hypothalamic-pituitary control of thyroid function and the role of hCG 1. Hypothalamic-pituitary-thyroid axis (HPTA) 2. Regulation of serum TSH 3. Thyrotropic action of hCG F. A global view of thyroidal economy in pregnancy III. Pathological Alterations of Thyroidal Regulation Associated with Pregnancy A. IDD 1. Consequences of iodine deficiency during pregnancy 2. Assessment of increased thyroidal stimulation 3. Gestational goitrogenesis and its prevention by iodine supplementation 4. Consequences of iodine deficiency for the offspring B. Hypothyroidism and pregnancy 1. Fertility and pregnancy outcome in hypothyroid women 2. Thyroid hormone replacement in the hypothyroid pregnant woman 3. Subclin...

[1]  J. Nicoloff,et al.  Thyroxine turnover during human pregnancy. , 1967, The Journal of clinical endocrinology and metabolism.

[2]  C. Peterson.  THYROID DISEASE AND FERTILITY , 1994, Immunology and Allergy Clinics of North America.

[3]  J. E. Silva,et al.  Interrelationships among serum thyroxine, triiodothyronine, reverse triiodothyronine, and thyroid-stimulating hormone in iodine-deficient pregnant women and their offspring: effects of iodine supplementation. , 1981, The Journal of clinical endocrinology and metabolism.

[4]  H. Jacobs,et al.  Management of endocrine disorders in pregnancy Part I--thyroid and parathyroid disease. , 1984, Postgraduate medical journal.

[5]  T. Mori,et al.  TSH receptor and LH receptor, 1995. , 1995, Endocrine journal.

[6]  N. Ishikawa,et al.  RECOVERY FROM FOETAL HYPOTHYROIDISM: EVIDENCE FOR THE SAFETY OF BREAST‐FEEDING WHILE TAKING PROPYLTHIOURACIL , 1989 .

[7]  Halnan Ke.  The radioiodine uptake of the human thyroid in pregnancy. , 1958 .

[8]  N. Yoshikawa,et al.  Thyroid-stimulating activity of human chorionic gonadotropin in sera of normal pregnant women. , 1990, Acta endocrinologica.

[9]  F. Delange.  Administration of iodized oil during pregnancy: a summary of the published evidence. , 1996, Bulletin of the World Health Organization.

[10]  L. Cole,et al.  Increased concentration of the free β‐subunit of human chorionic gonadotropin in hyperemesis gravidarum , 1994, Acta obstetricia et gynecologica Scandinavica.

[11]  L. Braverman,et al.  Human placenta is an active site of thyroxine and 3,3'5-triiodothyronine tyrosyl ring deiodination. , 1981, The Journal of clinical endocrinology and metabolism.

[12]  A. Pinchera,et al.  Serum thyroglobulin in thyroid carcinoma and other thyroid disorders , 1980, Journal of endocrinological investigation.

[13]  D. Glinoer,et al.  Maternal and neonatal thyroid function at birth in an area of marginally low iodine intake. , 1992, The Journal of clinical endocrinology and metabolism.

[14]  D. Glinoer,et al.  Serum levels of intact human chorionic gonadotropin (HCG) and its free a and β subunits, in relation to maternal thyroid stimulation during normal pregnancy , 1993, Journal of endocrinological investigation.

[15]  A. Biggi,et al.  Comparison of calculated and measured free thyroid hormones in serum in health and in abnormal states. , 1982, Clinical chemistry.

[16]  Safe use of iodized oil to prevent iodine deficiency in pregnant women: A WHO Statement , 1996 .

[17]  J. Thorell,et al.  A prospective critical evaluation of in vitro thyroid function tests. , 2009, Acta medica Scandinavica.

[18]  D. Fisher,et al.  Thyroid function at birth in infants of 30 to 45 weeks' gestation. , 1977, The Journal of pediatrics.

[19]  R. Canfield,et al.  Thyroid-stimulating activity of chorionic gonadotropin and luteinizing hormone. , 1978, The Journal of clinical endocrinology and metabolism.

[20]  R. Hoermann,et al.  Thyroid stimulation by placental factors , 1993, Journal of endocrinological investigation.

[21]  F. Trimarchi,et al.  Maternal hypothyroxinaemia during the first half of gestation in an iodine deficient area with endemic cretinism and related disorders , 1995, Clinical endocrinology.

[22]  N. Amino,et al.  Crucial role of serum human chorionic gonadotropin for the aggravation of thyrotoxicosis in early pregnancy in Graves' disease. , 1993, Thyroid : official journal of the American Thyroid Association.

[23]  M. de Swiet,et al.  Thyroxine dosage during pregnancy in women with primary hypothyroidism , 1993 .

[24]  D. Niejadlik,et al.  Comparison of thyroid function in each trimester of pregnancy with the use of triiodothyronine uptake, thyroxine iodine, free thyroxine, and free thyroxine index. , 1973, American journal of obstetrics and gynecology.

[25]  S. Nagataki,et al.  Suppressive doses of thyroxine do not accelerate age-related bone loss in late postmenopausal women. , 1995, Thyroid : official journal of the American Thyroid Association.

[26]  D. Glinoer.  Maternal and fetal impact of chronic iodine deficiency. , 1997, Clinical obstetrics and gynecology.

[27]  M. Sinha,et al.  Plasma thyrotropin and its response to thyrotropin releasing hormone in normal pregnancy. , 1973, Obstetrics and gynecology.

[28]  P. Laurberg.  Iodine intake--what are we aiming at? , 1994, The Journal of clinical endocrinology and metabolism.

[29]  J. Hershman,et al.  The thyrotropin in hydatidiform moles is human chorionic gonadotropin. , 1975, The Journal of clinical endocrinology and metabolism.

[30]  C. Laurell,et al.  A comparison of plasma protein changes induced by danazol, pregnancy, and estrogens. , 1979, The Journal of clinical endocrinology and metabolism.

[31]  P. Laurberg,et al.  Iodine deficiency in pregnancy in Denmark , 1993, Acta obstetricia et gynecologica Scandinavica.

[32]  H. Bürgi,et al.  Iodine deficiency disorders in Europe. , 1989, Bulletin of the World Health Organization.

[33]  G. Burrow.  Thyroid status in normal pregnancy. , 1990, The Journal of clinical endocrinology and metabolism.

[34]  C. Cheung,et al.  Urinary excretion of some proteins and enzymes during normal pregnancy. , 1989, Clinical chemistry.

[35]  E. Roti,et al.  Radioimmunoassay of thyroglobulin in human serum: concentrations in normal subjects and in patients with thyroid disease. , 1981, The Journal of nuclear medicine and allied sciences.

[36]  S. Mandel,et al.  Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis. , 1994, Thyroid : official journal of the American Thyroid Association.

[37]  R. Cobin,et al.  Detection of at-risk pregnancy by means of highly sensitive assays for thyroid autoantibodies , 1991 .

[38]  N. Wasserstrum,et al.  Perinatal consequences of maternal hypothyroidism in early pregnancy and inadequate replacement , 1995 .

[39]  Hershman Jm.  Hyperthyroidism induced by trophoblastic thyrotropin. , 1972 .

[40]  F. Karlsson,et al.  The effects of different doses of oral iodized oil on goiter size, urinary iodine, and thyroid-related hormones. , 1995, The Journal of clinical endocrinology and metabolism.

[41]  C. Hellwig,et al.  The thyroid in pregnancy. , 1957, American journal of obstetrics and gynecology.

[42]  W. Barron.  The pregnant surgical patient: medical evaluation and management. , 1984, Annals of internal medicine.

[43]  O. Clark,et al.  Surgery for thyroid disease. , 1985, The Medical clinics of North America.

[44]  D. Newman,et al.  The myth of goiter in pregnancy. , 1980, American journal of obstetrics and gynecology.

[45]  R. Dozeman,et al.  Hyperthyroidism appearing as hyperemesis gravidarum. , 1983, Archives of internal medicine.

[46]  D. Jurkovic,et al.  Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. , 1993, The Journal of clinical endocrinology and metabolism.

[47]  P. Walfish,et al.  Neonatal Thyroid Function in Iodine Deficiency , 1993 .

[48]  U. Kapil.  Iodine deficiency. , 1986, Indian pediatrics.

[49]  S. Stoffer,et al.  Clinical evaluation of a thyroxine binding globulin assay in calculating a free thyroxine index in normal, thyroid disease, and sick euthyroid patients. , 1987, Journal of Nuclear Medicine.

[50]  G. Burrow,et al.  Thyroid disease and pregnancy. , 1991, The Medical clinics of North America.

[51]  D. Glinoer,et al.  Thyroid function parameters and TSH-receptor antibodies in healthy subjects and Graves' disease patients: a sequential study before, during and after pregnancy. , 1993, Thyroidology.

[52]  T. Wilke.  Five kits for estimating free thyroxin concentration in serum evaluated, and correlated with other indices to thyroid status. , 1982, Clinical chemistry.

[53]  S. Refetoff,et al.  Relationship of oligosaccharide modification to the cause of serum thyroxine-binding globulin excess. , 1988, The Journal of clinical endocrinology and metabolism.

[54]  U. Stenman,et al.  Human chorionic gonadotropin (hCG) and thyroid function in early human pregnancy: circadian variation and evidence for intrinsic thyrotropic activity of hCG. , 1988, The Journal of clinical endocrinology and metabolism.

[55]  D. Glinoer,et al.  The thyrotrophic role of human chorionic gonadotrophin (hCG) in the early stages of twin (versus single) pregnancies , 1997, Clinical endocrinology.

[56]  R. Bakimer,et al.  WHAT REALLY HAPPENS TO FECUNDITY IN AUTOIMMUNE DISEASES? , 1994, Immunology and Allergy Clinics of North America.

[57]  M. Obregon,et al.  Thyroid hormones in tissues from fetal and adult rats. , 1994, Endocrinology.

[58]  J. Lazarus,et al.  Review Thyroid disease in relation to pregnancy , 1991 .

[59]  G. Beckett,et al.  Limitations of new thyroid function tests in pregnancy. , 1985, Clinica chimica acta; international journal of clinical chemistry.

[60]  N. Miller,et al.  Consideration on some hormone binding proteins patterns during pregnancy. , 1991, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[61]  N. Amino,et al.  Thyroxine requirement during pregnancy for replacement therapy of hypothyroidism , 1990, Obstetrics and gynecology.

[62]  G. Burrow.  3 – The Hypothalamic-Pituitary-Thyroid Axis , 1990 .

[63]  J. Hershman,et al.  The role of chorionic gonadotropin in transient hyperthyroidism of hyperemesis gravidarum. , 1991, Transactions of the Association of American Physicians.

[64]  G. Braunstein,et al.  Comparison of thyroid stimulators and thyroid hormone concentrations in the sera of pregnant women. , 1979, The Journal of clinical endocrinology and metabolism.

[65]  R. Cobin,et al.  Detection of at-risk pregnancy by means of highly sensitive assays for thyroid autoantibodies. , 1990, JAMA.

[66]  E. Roti,et al.  Clinical review 80: Management of hyperthyroidism and hypothyroidism in the pregnant woman. , 1996, The Journal of clinical endocrinology and metabolism.

[67]  N. Yoshikawa,et al.  Human chorionic gonadotropin promotes thyroid growth via thyrotropin receptors in FRTL-5 cells. , 1990, Endocrinologia japonica.

[68]  G. Holzman,et al.  Evidence for the placental transfer of tri-iodothyronine in human beings. , 1967, The New England journal of medicine.

[69]  G. Burrow.  Thyroid function and hyperfunction during gestation. , 1993, Endocrine reviews.

[70]  S. Y. Cheng,et al.  Thyroxine transport proteins of plasma. Molecular properties and biosynthesis. , 1978, Recent progress in hormone research.

[71]  J. Jameson,et al.  Regulation of chorionic gonadotropin gene expression. , 1993, Endocrine reviews.

[72]  E. Endert,et al.  Thyroid function and thyroid size in normal pregnant women living in an iodine replete area , 1994, Clinical endocrinology.

[73]  J. Hershman,et al.  Increased in vitro thyrotropic activity of partially sialated human chorionic gonadotropin extracted from hydatidiform moles of patients with hyperthyroidism. , 1993, The Journal of clinical endocrinology and metabolism.

[74]  A. Toft.  Thyroxine therapy. , 1994, The New England journal of medicine.

[75]  N. Amino,et al.  Prediction of post‐partum Graves' thyrotoxicosis by measurement of thyroid stimulating antibody in early pregnancy , 1994, Clinical endocrinology.

[76]  D. Glinoer,et al.  Partial reversibility during late postpartum of thyroid abnormalities associated with pregnancy. , 1992, The Journal of clinical endocrinology and metabolism.

[77]  T. Goodwin,et al.  Thyroid disorders of pregnancy. , 1995, Endocrinology and metabolism clinics of North America.

[78]  J. Crooks,et al.  A COMPARATIVE STUDY OF IODINE METABOLISM IN PREGNANCY, SPORADIC GOITRE AND THYROTOXICOSIS. , 1965, Acta Endocrinologica.

[79]  D. Glinoer,et al.  Pregnancy in patients with mild thyroid abnormalities: maternal and neonatal repercussions. , 1991, The Journal of clinical endocrinology and metabolism.

[80]  C. Peterson,et al.  De novo clinical hypothyroidism in pregnancies complicated by type I diabetes, subclinical hypothyroidism, and proteinuria: a new syndrome. , 1988, American journal of obstetrics and gynecology.

[81]  D. Cooper.  Antithyroid drugs: to breast-feed or not to breast-feed. , 1987, American journal of obstetrics and gynecology.

[82]  N. Amino,et al.  Morning Sickness and Thyroid Function in Normal Pregnancy , 1988, Obstetrics and gynecology.

[83]  S. Ratnaike,et al.  Comparison of four methods for free thyroxin. , 1991, Clinical Chemistry.

[84]  A. J. Herle,et al.  Radioimmunoassay for measurement of thyroglobulin in human serum. , 1973, The Journal of clinical investigation.

[85]  K. Nakatani,et al.  Effect of albumin concentration on the assay of serum free thyroxin by equilibrium radioimmunoassay with labeled thyroxin analog (Amerlex Free T4). , 1983, Clinical chemistry.

[86]  R. Desai,et al.  SPECTRUM OF THYROID FUNCTION ABNORMALITIES IN GESTATIONAL TROPHOBLASTIC NEOPLASIA , 1988, Clinical endocrinology.

[87]  D. Glinoer,et al.  Antithyroid antibodies underlying thyroid abnormalities and miscarriage or pregnancy induced hypertension , 1993, British journal of obstetrics and gynaecology.

[88]  J. Potter.  Hypothyroidism and reproductive failure. , 1980, Surgery, gynecology & obstetrics.

[89]  Y. Murata,et al.  Effect of estrogen on the synthesis and secretion of thyroxine-binding globulin by a human hepatoma cell line, Hep G2. , 1988, Molecular endocrinology.

[90]  T. Kitajima,et al.  Fragmentation of the beta-subunit of human chorionic gonadotropin produced by choriocarcinoma. , 1988, Endocrinology.

[91]  T. Helenius,et al.  Improved dialysis method for free thyroxin in serum compared with five commercial radioimmunoassays in nonthyroidal illness and subjects with abnormal concentrations of thyroxin-binding globulin. , 1983, Clinical chemistry.

[92]  P. Dodge.  The Damaged Brain of Iodine Deficiency , 1996 .

[93]  G. Krassas,et al.  THYROTOXICOSIS IN PREGNANCY: RESULTS OF TREATMENT BY ANTITHYROID DRUGS COMBINED WITH T4 , 1983 .

[94]  Y. Mori,et al.  Human chorionic gonadotropin induces c-myc mRNA expression via TSH receptor in FRTL-5 rat thyroid cells. , 1992, Thyroid : official journal of the American Thyroid Association.

[95]  JOHN H. Parker.  Amerlex free triiodothyronine and free thyroxine levels in normal pregnancy , 1985, British journal of obstetrics and gynaecology.

[96]  E. Cooper,et al.  Serum concentrations of 3,3',5'-triiodothyronine (reverse T3) in normal pregnancy. , 1980, Clinica chimica acta; international journal of clinical chemistry.

[97]  W. Frei.  The Thyroid Gland, Iodine and Reproduction. , 2022 .

[98]  Burrow Gh.  Thyroid status in normal pregnancy. , 1990 .

[99]  J. Mckillop,et al.  Thyroid function tests are rarely abnormal in patients with severe hyperemesis gravidarum , 1992, Clinical endocrinology.

[100]  P. Larsen,et al.  Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. , 1981, Endocrine reviews.

[101]  W. Göpel,et al.  Earliest prevention of endemic goiter by iodine supplementation during pregnancy. , 1996, European journal of endocrinology.

[102]  J. Magner,et al.  Thyroid-stimulating hormone: biosynthesis, cell biology, and bioactivity. , 1990, Endocrine reviews.

[103]  J. Dunn,et al.  Oral iodized oil for correcting iodine deficiency: optimal dosing and outcome indicator selection. , 1994, The Journal of clinical endocrinology and metabolism.

[104]  W. Seitz,et al.  Thyroid status during pregnancy and post partum in regions of iodine deficiency and endemic goiter. , 1986, Endocrinologia experimentalis.

[105]  P. Larsen,et al.  Neonatal thyroid function after propylthiouracil therapy for maternal Graves' disease. , 1981, The New England journal of medicine.

[106]  S. Refetoff,et al.  The value of serum thyroglobulin measurement in clinical practice. , 1983, JAMA.

[107]  C. Librach,et al.  Maternal weight loss associated with hyperemesis gravidarum: a predictor of fetal outcome. , 1989, American journal of obstetrics and gynecology.

[108]  A. Donda,et al.  Sex steroids modulate the pituitary parameters involved in the regulation of TSH secretion in the rat. , 1990, Acta endocrinologica.

[109]  K. Ain,et al.  Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: a mechanism for estrogen-induced elevation of serum TBG concentration. , 1987, The Journal of clinical endocrinology and metabolism.

[110]  J. Hershman.  Hyperthyroidism induced by trophoblastic thyrotropin. , 1972, Mayo Clinic proceedings.

[111]  W. Jeffcoate,et al.  Recurrent pregnancy‐induced thyrotoxicosis presenting as hyperemesis gravidarum. Case report , 1985, British journal of obstetrics and gynaecology.

[112]  R. Taylor,et al.  Successful management of hyperemesis gravidarum using steroid therapy. , 1996, QJM : monthly journal of the Association of Physicians.

[113]  Z. Kraiem,et al.  Human chorionic gonadotropin stimulates thyroid hormone secretion, iodide uptake, organification, and adenosine 3',5'-monophosphate formation in cultured human thyrocytes. , 1994, The Journal of clinical endocrinology and metabolism.

[114]  D. Glinoer,et al.  Stimulation of thyroxine-binding globulin synthesis by isolated rhesus monkey hepatocytes after in vivo beta-estradiol administration. , 1977, Endocrinology.

[115]  E. Maymon,et al.  Hyperemesis gravidarum: epidemiologic features, complications and outcome. , 1995, European journal of obstetrics, gynecology, and reproductive biology.

[116]  B. N. Premachandra,et al.  Effect of pregnancy on thyroxine binding globulin (TBG) in partial TBG deficiency. , 1977, The American journal of the medical sciences.

[117]  T. Steck,et al.  Thyroid autoantibodies in euthyroid non-pregnant women with recurrent spontaneous abortions. , 1995, Human reproduction.

[118]  J. Robbins,et al.  Thyroxinebinding by serum protein in pregnancy and in the newborn. , 1958, The Journal of clinical investigation.

[119]  S. P. Porterfield,et al.  The role of thyroid hormones in prenatal and neonatal neurological development--current perspectives. , 1993, Endocrine reviews.

[120]  F. Cunningham,et al.  Pregnancy and Thyroid Disease , 1991, Clinical obstetrics and gynecology.

[121]  L. Shenkman,et al.  Abnormal Thyroid Function In Hyperemesis Gravidarum , 1989, Acta obstetricia et gynecologica Scandinavica.

[122]  I. Mcdougall,et al.  Hypothyroid women need more thyroxine when pregnant. , 1995, The Journal of family practice.

[123]  G. Burrow,et al.  The effect of oral contraceptive steroids on the response of thyroid-stimulating hormone to thyrotropin-releasing hormone. , 1975, The Journal of clinical endocrinology and metabolism.

[124]  L. Sherwood,et al.  The effects of pregnancy on circulating triiodothyronine. , 1971, The Journal of clinical endocrinology and metabolism.

[125]  A. Toft.  Drug therapy : thyroxine therapy , 1994 .

[126]  K. Nakatani,et al.  Serum ratio of triiodothyronine to thyroxine, and thyroxine-binding globulin and calcitonin concentrations in Graves' disease and destruction-induced thyrotoxicosis. , 1981, The Journal of clinical endocrinology and metabolism.

[127]  K. Leveno,et al.  Hypothyroidism Complicating Pregnancy , 1988, Obstetrics and gynecology.

[128]  D. A. Fischer.  Ontogenesis of hypothalamic-pituitary-thyroid function in the human fetus , 1985 .

[129]  G. Benker,et al.  Antithyroid drug treatment of Graves' disease in pregnancy: long-term effects on somatic growth, intellectual development and thyroid function of the offspring. , 1990, Acta endocrinologica.

[130]  J. Robbins.  Thyroxine transport and the free hormone hypothesis. , 1992, Endocrinology.

[131]  P. Laurberg,et al.  Amelioration of some pregnancy-associated variations in thyroid function by iodine supplementation. , 1993, The Journal of clinical endocrinology and metabolism.

[132]  D. Fisher,et al.  Fetal thyroid metabolism: a pluralistic system. , 1994, Thyroid : official journal of the American Thyroid Association.

[133]  J. Hershman.  Role of human chorionic gonadotropin as a thyroid stimulator. , 1992, The Journal of clinical endocrinology and metabolism.

[134]  M. Mitchell,et al.  Prevalence of thyroid deficiency in pregnant women , 1991, Clinical endocrinology.

[135]  S. Werner,et al.  The effect of triiodothyronine administration on the elevated protein-bound iodine level in human pregnancy. , 1958, American journal of obstetrics and gynecology.

[136]  E. Saling,et al.  AMNIOTIC FLUID CONCENTRATIONS OF 3,3′,5′‐TRI‐IODOTHYRONINE (REVERSE T3), 3,3′‐DI‐IODOTHYRONINE, 3,5,3′‐TRI‐IODOTHYRONINE (T3) AND THYROXINE (T4) IN NORMAL AND COMPLICATED PREGNANCY , 1979, Clinical endocrinology.

[137]  J. Franklyn,et al.  Consensus statement for good practice and audit measures in the management of hypothyroidism and hyperthyroidism , 1996 .

[138]  S. Yen,et al.  Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management , 1999 .

[139]  D. Glinoer,et al.  Status of Iodine Nutrition and Thyroid Function in Belgium , 1993 .

[140]  R. Norman,et al.  Choriogonadotropin-mediated thyrotoxicosis in a man. , 1991, Clinical chemistry.

[141]  A. Bold,et al.  Interpretation of in‐vitro thyroid function tests during pregnancy , 1983, British journal of obstetrics and gynaecology.

[142]  D. Glinoer,et al.  Reassessment of antithyroid drug therapy of Graves' disease. , 1993, Annual review of medicine.

[143]  B. Morris,et al.  A longitudinal study of thyroid function in pregnancy. , 1989, Clinical chemistry.

[144]  E. Paloyan,et al.  Sex hormone modulation of serum TSH levels. , 1987, Surgery.

[145]  Pochin Ee.  The iodine uptake of the human thyroid throughout the menstrual cycle and in pregnancy. , 1952 .

[146]  A. Kung,et al.  Hyperthyroidism during pregnancy due to coexistence of struma ovarii and Graves' disease. , 1990, Postgraduate medical journal.

[147]  U. Feldt-Rasmussen,et al.  Thyroid function and autoimmune manifestations in insulin-dependent diabetes mellitus during and after pregnancy. , 1991, Acta endocrinologica.

[148]  J. E. Midgley,et al.  Low-normal concentrations of free thyroxin in serum in late pregnancy: physiological fact, not technical artefact. , 1989, Clinical chemistry.

[149]  C. Rodeck,et al.  MATURATION OF THYROID FUNCTION IN NORMAL HUMAN FOETUSES , 1989, Clinical endocrinology.

[150]  R. Lagasse,et al.  Fetal hypothyroidism and maternal thyroid status in severe endemic goiter. , 1978, The Journal of clinical endocrinology and metabolism.

[151]  R. Pelkonen,et al.  Serum thyrotrophin and the response to thyrotrophin releasing hormone in symptomless autoimmune thyroiditis and in borderline and overt hypothyroidism. , 1974, Acta endocrinologica.

[152]  A. Ermans.  Prevention of iodine deficiency disorders by oral iodized oil. , 1994, European journal of endocrinology.

[153]  J. Hershman,et al.  Hydatidiform mole--a cause of clinical hyperthyroidism. Report of two cases with evidence that the molar tissue secreted a thyroid stimulator. , 1971, The New England journal of medicine.

[154]  D. Glinoer,et al.  Effects of estrogen on thyroxine-binding globulin metabolism in rhesus monkeys. , 1977, Endocrinology.

[155]  P. Laurberg,et al.  A longitudinal study of serum TSH, and total and free iodothyronines during normal pregnancy. , 1982, Acta endocrinologica.

[156]  F. Delange.  Iodine Nutrition and Congenital Hypothyroidism , 1989 .

[157]  J. Davison.  The Kidney in Pregnancy: A Review , 1983, Journal of the Royal Society of Medicine.

[158]  C. Beckers,et al.  Diagnostic value of free triiodothyronine in serum. , 1986, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[159]  R. Chin,et al.  Thyroxine concentration and outcome of hyperemetic pregnancies , 1988, British journal of obstetrics and gynaecology.

[160]  J. Parma,et al.  The thyrotropin receptor and the regulation of thyrocyte function and growth. , 1992, Endocrine reviews.

[161]  I. Sherif,et al.  Treatment of hyperthyroidism in pregnancy , 1991, Acta obstetricia et gynecologica Scandinavica.

[162]  M. Ascoli,et al.  On the structure of the luteinizing hormone/chorionic gonadotropin receptor. , 1989, Endocrine reviews.

[163]  J. French,et al.  The incidence of thyroid disorders in the community: a twenty‐year follow‐up of the Whickham Survey , 1995, Clinical endocrinology.

[164]  N. Ishikawa,et al.  Drug therapy for Graves' disease during pregnancy. , 1986, The New England journal of medicine.

[165]  R. Mortimer,et al.  Graves'DISEASE IN PREGNANCY: TSH RECEPTOR BINDING INHIBITING IMMUNOGLOBULINS AND MATERNAL AND NEONATAL THYROID FUNCTION , 1990, Clinical endocrinology.

[166]  K. Ichihara,et al.  LONGITUDINAL STUDY OR SERUM THYROID HORMONES, CHORIONIC GONADOTROPHIN AND THYROTROPHIN DURING AND AFTER NORMAL PREGNANCY , 1979, Clinical endocrinology.

[167]  L. Bartalena,et al.  Thyroid hormone transport proteins. , 1993, Clinics in laboratory medicine.

[168]  J. Mestman,et al.  Perinatal outcome in hypothyroid pregnancies , 1993, Obstetrics and gynecology.

[169]  J. Lazarus,et al.  Thyroid disease in relation to pregnancy. , 1991, Clinical endocrinology.

[170]  J. Goldman,et al.  Components of the total serum thyroid hormone concentrations during pregnancy: high free thyroxine and blunted thyrotropin (TSH) response to TSH-releasing hormone in the first trimester. , 1985, The Journal of clinical endocrinology and metabolism.

[171]  M. Reinilä,et al.  Serial prolactin and thyrotropin responses to thyrotropin-releasing hormone throughout normal human pregnancy. , 1979, The Journal of clinical endocrinology and metabolism.

[172]  I. Fogelman,et al.  Thyroid function in normal pregnancy , 1989 .

[173]  A. Vannotti,et al.  Relationships between blood thyrotrophin level, protein bound iodine and free thyroxine concentration in man under normal physiological conditions. , 1969, Acta endocrinologica.

[174]  C. Hollander,et al.  Thyroidal complications of pregnancy. , 1977, The Medical clinics of North America.

[175]  J. Pierce,et al.  Human chorionic thyrotropin: further characterization and study of its secretion during pregnancy. , 1969, The Journal of clinical endocrinology and metabolism.

[176]  E. Pochin.  The iodine uptake of the human thyroid throughout the menstrual cycle and in pregnancy. , 1952, Clinical science.

[177]  D. Glinoer,et al.  Thyroxine-binding globulin biosynthesis in isolated monkey hepatocytes. , 1976, Biochimica et biophysica acta.

[178]  D. Fisher,et al.  Maturation of Thyroid Hormone Actions , 1989 .

[179]  R. Ekins,et al.  Pregnancy-induced changes in thyroid function: role of human chorionic gonadotropin as putative regulator of maternal thyroid. , 1991, The Journal of clinical endocrinology and metabolism.

[180]  L. R. Fryman,et al.  Iodine intake related to milk iodine and performance of dairy cattle. , 1972, Journal of dairy science.

[181]  M. Kaplan,et al.  Monitoring thyroxine treatment during pregnancy. , 1992, Thyroid : official journal of the American Thyroid Association.

[182]  D. Glinoer.  Maternal thyroid function in pregnancy , 1993, Journal of endocrinological investigation.

[183]  D. Glinoer,et al.  Goiter and pregnancy: a new insight into an old problem. , 1992, Thyroid : official journal of the American Thyroid Association.

[184]  E. Sheridan,et al.  THYROID FUNCTION IN CHORIOCARCINOMA: DEMONSTRATION OF A THYROID STIMULATING ACTIVITY IN SERUM USING FRTL‐5 and HUMAN THYROID CELLS , 1990, Clinical endocrinology.

[185]  P. Laurberg,et al.  Urinary Iodine Excretion is Low and Serum Thyroglobulin High in Pregnant Women in Parts of Denmark , 1988, Acta obstetricia et gynecologica Scandinavica.

[186]  T. Li,et al.  Thyroid function in trophoblastic disease , 1987, British journal of obstetrics and gynaecology.

[187]  E. Roti,et al.  Thyroid function evaluation by different commercially available free thyroid hormone measurement kits in term pregnant women and their newborns , 1991, Journal of endocrinological investigation.

[188]  S. Sabatini,et al.  The effect of pregnancy on renal function: physiology and pathophysiology. , 1992, The American journal of the medical sciences.

[189]  D. Glinoer,et al.  Regulation of maternal thyroid during pregnancy. , 1990, The Journal of clinical endocrinology and metabolism.

[190]  R. Hoermann,et al.  Thyrotropic activity of acidic isoelectric variants of human chorionic gonadotropin from trophoblastic tumors. , 1986, Endocrinology.

[191]  D. Cooper,et al.  Pharmacology of propylthiouracil (PTU) in pregnant hyperthyroid women: correlation of maternal PTU concentrations with cord serum thyroid function tests. , 1986, The Journal of clinical endocrinology and metabolism.

[192]  L. Bartalena.  Recent achievements in studies on thyroid hormone-binding proteins. , 1990, Endocrine reviews.

[193]  P. Scriba,et al.  Thyroxine-binding globulin: investigation of microheterogeneity. , 1981, The Journal of clinical endocrinology and metabolism.

[194]  M. Obregon,et al.  Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. , 1985, Endocrinology.

[195]  A. Turnbull,et al.  Comparative incidence of goitre in pregnancy in Iceland and Scotland. , 1967, Lancet.

[196]  N. Amino,et al.  Gestational thyrotoxicosis and hyperemesis gravidarum: possible role of hCG with higher stimulating activity , 1993, Clinical endocrinology.

[197]  T. Pettersson,et al.  Thyroid associated components in serum during normal pregnancy. , 1982, Acta endocrinologica.

[198]  S. Refetoff,et al.  Metabolism of thyroxine-binding globulin in man. Abnormal rate of synthesis in inherited thyroxine-binding globulin deficiency and excess. , 1976, The Journal of clinical investigation.

[199]  R. Swaminathan,et al.  Thyroid function in hyperemesis gravidarum. , 1989, Acta endocrinologica.

[200]  K. Catt,et al.  Assessment of urinary thyrotropin-competing activity in choriocarcinoma and thyroid disease: further evidence for human chorionic gonadotropin interacting at the thyroid cell membrane. , 1979, The Journal of clinical endocrinology and metabolism.

[201]  Y. Iwatani,et al.  Aggravation of thyrotoxicosis in early pregnancy and after delivery in Graves' disease. , 1982, The Journal of clinical endocrinology and metabolism.

[202]  F. Delange,et al.  The disorders induced by iodine deficiency. , 1994, Thyroid : official journal of the American Thyroid Association.

[203]  M. Sugawara,et al.  Human chorionic gonadotropin stimulates iodide uptake, adenylate cyclase, and deoxyribonucleic acid synthesis in cultured rat thyroid cells. , 1988, The Journal of clinical endocrinology and metabolism.

[204]  J. Hershman,et al.  Thyrotropic action of human chorionic gonadotropin. , 1995, Thyroid : official journal of the American Thyroid Association.

[205]  D. Glinoer,et al.  Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. , 1994, The Journal of clinical endocrinology and metabolism.

[206]  P. Larsen,et al.  Maternal and Fetal Thyroid Function , 1994 .

[207]  N. Ishikawa,et al.  Antithyroid drug therapy for Graves' disease during pregnancy. Optimal regimen for fetal thyroid status. , 1986, The New England journal of medicine.

[208]  D. Sugrue,et al.  HYPERTHYROIDISM COMPLICATING PREGNANCY: RESULTS OF TREATMENT BY ANTITHYROID DRUGS IN 77 PREGNANCIES , 1980, British journal of obstetrics and gynaecology.

[209]  C. Hobel,et al.  Thyroid function in the preterm fetus. , 1970, Pediatrics.

[210]  M. Benmiloud,et al.  Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy. , 1994, European journal of endocrinology.

[211]  N. Gleicher,et al.  The association of antithyroid antibodies in euthyroid nonpregnant women with recurrent first trimester abortions in the next pregnancy. , 1993, Fertility and sterility.

[212]  T. Wilke.  Free thyroid hormone index, thyroid hormone/thyroxin-binding globulin ratio, triiodothyronine uptake, and thyroxin-binding globulin compared for diagnostic value regarding thyroid function. , 1983, Clinical chemistry.

[213]  J. Robbins.  Inherited variations in thyroxine transport. , 1973, The Mount Sinai journal of medicine, New York.

[214]  J. Mestman,et al.  Successful outcome of pregnancy in women with hypothyroidism. , 1981, Annals of internal medicine.

[215]  W. Beierwaltes,et al.  THE EFFECT OF MATERNAL THYROID FUNCTION ON FETAL THYROID FUNCTION AND DEVELOPMENT , 1959 .

[216]  Wu Cy.  [Hyperthyroidism and pregnancy; clinical analysis of 21 cases]. , 1957 .

[217]  J. Hershman,et al.  Activation of the thyrotropin (TSH) receptor by human chorionic gonadotropin and luteinizing hormone in Chinese hamster ovary cells expressing functional human TSH receptors. , 1993, The Journal of clinical endocrinology and metabolism.

[218]  L. Kivisaari,et al.  Ultrasonography of the thyroid during pregnancy , 1989, Journal of clinical ultrasound : JCU.

[219]  D. Glinoer,et al.  A randomized trial for the treatment of mild iodine deficiency during pregnancy: maternal and neonatal effects. , 1995, The Journal of clinical endocrinology and metabolism.

[220]  L. Mignot,et al.  Hyperthyroïdie et hypersécrétion de gonadotrophine chorionique au cours d'un adénocarcinome gastrique , 1994 .

[221]  M. Ascoli,et al.  The lutropin/choriogonadotropin receptor ... 4 years later. , 1993, Endocrine reviews.

[222]  D. Glinoer.  Thyroid Regulation During Pregnancy , 1993 .

[223]  鶴田 絵里子.  PATHOGENIC ROLE OF ASIALO HUMAN CHORIONIC GONADOTROPIN IN GESTATIONAL THYROTOXICOSIS , 1995 .

[224]  A. Pinchera,et al.  Serum thyrotropin by ultrasensitive immunoradiometric assay and serum free thyroid hormones in pregnancy , 1986, Journal of endocrinological investigation.

[225]  D. Doniach,et al.  Serum thyroglobulin levels in healthy subjects and in patients with thyroid disease. , 1969, The Journal of clinical endocrinology and metabolism.

[226]  S. Toda,et al.  A rare case of primary pulmonary choriocarcinoma in a male: immunohistochemical detection for human chorionic gonadotropin, epidermal growth factor (EGF) and EGF-receptor. , 1995, Endocrine journal.

[227]  S. Ohlen,et al.  [The effect of earlier pregnancies on the prevalence of goiter and nodules in thyroid-healthy women]. , 2008, Deutsche Medizinische Wochenschrift.

[228]  D. Wing,et al.  A comparison of propylthiouracil versus methimazole in the treatment of hyperthyroidism in pregnancy. , 1994, American journal of obstetrics and gynecology.

[229]  J. King,et al.  Trace Element Nutrition during Pregnancy , 1994, Clinical obstetrics and gynecology.

[230]  M. Jonckheer,et al.  Thyroid hormone reserve in asymptomatic autoimmune thyroiditis. , 1987, Acta endocrinologica.

[231]  P. Larsen.  Commentary: Monitoring Thyroxine Treatment During Pregnancy , 1992 .

[232]  G. Braunstein,et al.  Comparison of serum pituitary thyrotropin and chorionic gonadotropin concentrations throughout pregnancy. , 1976, The Journal of clinical endocrinology and metabolism.

[233]  F. Trimarchi,et al.  Hypothyroidism induced by pregnancy in a patient submitted to suppressive L-thyroxine therapy , 1987, Journal of Endocrinological Investigation.

[234]  M. Mucci,et al.  Serum free thyroid hormones in different degrees of hypothyroidism and in euthyroid autoimmune thyroiditis. , 1987, Acta endocrinologica.

[235]  M. Sugawara,et al.  Human chorionic gonadotropin stimulates iodide uptake, adenylate cyclase, and deoxyribonucleic acid synthesis in cultured rat thyroid cells. , 1988, The Journal of clinical endocrinology and metabolism.

[236]  J. Kvetny,et al.  Nuclear thyroxine and 3,5,3'-triiodothyronine receptors in human mononuclear blood cells during pregnancy. , 1984, Acta Endocrinologica.

[237]  C. Jones,et al.  Hyperemesis gravidarum due to thyrotoxicosis. , 1980, Postgraduate medical journal.

[238]  A. Turnbull,et al.  THE PHYSIOLOGICAL CHANGES IN THYROID FUNCTION DURING PREGNANCY. , 1964, Clinical science.

[239]  Y. Tomer,et al.  Human chorionic gonadotropin (hCG) interacts directly with recombinant human TSH receptors. , 1992, The Journal of clinical endocrinology and metabolism.

[240]  K. Collison,et al.  Postpartum thyroid dysfunction in Mid Glamorgan , 1988, British medical journal.

[241]  M. Kaplan,et al.  Characteristics of thyroxine 5'-deiodination in cultured human placental cells. Regulation by iodothyronines. , 1985, The Journal of clinical investigation.

[242]  A. Grimaldi,et al.  The effects of iodoprophylaxis on thyroid size during pregnancy. , 1991, American journal of obstetrics and gynecology.

[243]  D. Yarmush,et al.  The application of chemical studies of human chorionic gonadotropin to visualize its three-dimensional structure. , 1993, Endocrine reviews.

[244]  K. Takeda,et al.  Effect of stripping thyroxin from thyroxin-binding globulin on the measurement of free thyroxin in serum by equilibrium dialysis and by radioimmunoassay. , 1990, Clinical chemistry.

[245]  J. F. Brown,et al.  Maternal hypothyroxinemia: psychoneurological deficits of progeny. , 1991, Annals of clinical and laboratory science.

[246]  F. Grodstein,et al.  Self‐Reported Use of Pharmaceuticals and Primary Ovulatory Infertility , 1993, Epidemiology.

[247]  J. Oppenheimer.  Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones. , 1968, The New England journal of medicine.

[248]  A. Kriplani,et al.  Maternal and perinatal outcome in thyrotoxicosis complicating pregnancy. , 1994, European journal of obstetrics, gynecology, and reproductive biology.

[249]  J. Hershman,et al.  Thyrotropic activity of basic isoelectric forms of human chorionic gonadotropin extracted from hydatidiform mole tissues. , 1994, The Journal of clinical endocrinology and metabolism.

[250]  P. Laurberg.  Iodothyronine release from the perfused canine thyroid following cessation of stimulation: rapid decline of triiodothyronines in comparison with thyroxine. , 1980, The Journal of clinical investigation.

[251]  D. Glinoer,et al.  Use of direct thyroxine-binding globulin measurement in the evaluation of thyroid function , 1978, Journal of endocrinological investigation.

[252]  R. Utiger,et al.  Serum thyroxine-binding globulin: determination by competitive ligand-binding assay in thyroid disease and pregnancy. , 1977, Acta Endocrinologica.

[253]  C. Selby,et al.  Morning sickness and thyroid function , 1986, British journal of obstetrics and gynaecology.

[254]  L. Hegedüs,et al.  Serum thyroglobulin during the menstrual cycle, during pregnancy, and post partum. , 1989, Acta endocrinologica.

[255]  F. Delange,et al.  Physiopathology of iodine nutrition during pregnancy, lactation and early postnatal life , 1986 .

[256]  L. Hegedüs,et al.  Ultrasonographically determined thyroid size in pregnancy and post partum: the goitrogenic effect of pregnancy. , 1989, American journal of obstetrics and gynecology.

[257]  Drury Mi.  Hyperthyroidism in pregnancy. , 1986 .