A decade of Australian methotrexate dosing errors

Objective: Accidental daily dosing of methotrexate can result in life‐threatening toxicity. We investigated methotrexate dosing errors reported to the National Coronial Information System (NCIS), the Therapeutic Goods Administration Database of Adverse Event Notifications (TGA DAEN) and Australian Poisons Information Centres (PICs).

[1]  Matthew C Grissinger Severe Harm and Death Associated With Errors and Drug Interactions Involving Low-Dose Methotrexate. , 2018, P & T : a peer-reviewed journal for formulary management.

[2]  S. Pearson,et al.  The Australian Pharmaceutical Benefits Scheme data collection: a practical guide for researchers , 2015, BMC Research Notes.

[3]  D. Arnett,et al.  Genetic Variants Associated with Methotrexate Efficacy and Toxicity in Early Rheumatoid Arthritis: Results from the Treatment of Early Aggressive Rheumatoid Arthritis Trial , 2013, The Pharmacogenomics Journal.

[4]  S. Morgan,et al.  Folate supplementation during methotrexate therapy for rheumatoid arthritis. , 2010, Clinical and experimental rheumatology.

[5]  K. Schmiegelow Advances in individual prediction of methotrexate toxicity: a review , 2009, British journal of haematology.

[6]  P. Bookstaver,et al.  Multiple toxic effects of low-dose methotrexate in a patient treated for psoriasis. , 2008, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[7]  C. Koczmara,et al.  Oral Methotrexate: Preventing Inadvertent Daily Administration , 2008 .

[8]  A. Roach,et al.  Methods to enhance the safety of methotrexate prescribing , 2007, Journal of clinical pharmacy and therapeutics.

[9]  B. Cronstein,et al.  Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. , 2007, Bulletin of the NYU hospital for joint diseases.

[10]  P. Fritz,et al.  Iatrogenically-related, fatal methotrexate intoxication: a series of four cases. , 2006, Forensic science international.

[11]  R. Misra,et al.  Low-dose methotrexate-induced pancytopenia , 2006, Clinical Rheumatology.

[12]  G. Mall,et al.  Deaths following methotrexate overdoses by medical staff. , 2005, The Journal of rheumatology.

[13]  Michael R. Cohen,et al.  Reported medication errors associated with methotrexate. , 2004, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.