Circulating and/or cutaneous irisin resistance: A novel link among androgenetic alopecia, comorbid metabolic syndrome and cardiovascular risks

Androgenetic alopecia (AGA) is a common cause of hair loss in both genders that may be associated with disturbed systemic metabolism. Irisin is a hormone‐like myokine that greatly influences systemic metabolism and is linked to cardiovascular diseases.

[1]  F. Ahmad,et al.  FNDC5/Irisin: Physiology and Pathophysiology , 2022, Molecules.

[2]  M. Shimaoka,et al.  Irisin supports integrin-mediated cell adhesion of lymphocytes , 2021, Biochemistry and biophysics reports.

[3]  C. Drevon,et al.  Progress and Challenges in the Biology of FNDC5 and Irisin , 2021, Endocrine reviews.

[4]  Tatsuo Kawai,et al.  Adipose Tissue Inflammation and Metabolic Dysfunction in Obesity. , 2020, American journal of physiology. Cell physiology.

[5]  I. Ahmad,et al.  Correlations between serum testosterone and irisin levels in a sample of Egyptian men with metabolic syndrome; (case-control study) , 2020, Archives of physiology and biochemistry.

[6]  B. Spiegelman,et al.  Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors , 2018, Cell.

[7]  P. Rather,et al.  Severe androgenetic alopecia as a maker of metabolic syndrome in male patients of androgenetic alopecia: a hospital based case control study , 2017 .

[8]  W. Deng.  Association of Serum Irisin Concentrations with Presence and Severity of Coronary Artery Disease , 2016, Medical science monitor : international medical journal of experimental and clinical research.

[9]  N. Balato,et al.  Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity , 2016, Expert review of clinical immunology.

[10]  S. Kurose,et al.  Relationships between serum irisin levels and metabolic parameters in Japanese patients with obesity , 2016, Obesity science & practice.

[11]  H. Li,et al.  Free androgen index and Irisin in polycystic ovary syndrome , 2016, Journal of Endocrinological Investigation.

[12]  H. Völzke,et al.  Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population , 2016, PloS one.

[13]  F. Rizk,et al.  Irisin levels in relation to metabolic and liver functions in Egyptian patients with metabolic syndrome. , 2016, Canadian journal of physiology and pharmacology.

[14]  Ning Chen,et al.  Irisin, an exercise‐induced myokine as a metabolic regulator: an updated narrative review , 2016, Diabetes/metabolism research and reviews.

[15]  L. Xiang,et al.  Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice. , 2015, Atherosclerosis.

[16]  C. Drevon,et al.  Irisin – a myth rather than an exercise-inducible myokine , 2015, Scientific Reports.

[17]  Jiaqi Chen,et al.  Irisin: a new molecular marker and target in metabolic disorder , 2015, Lipids in Health and Disease.

[18]  M. Çetin,et al.  Androgenetic alopecia is associated with increased arterial stiffness in asymptomatic young adults , 2015, Journal of the European Academy of Dermatology and Venereology : JEADV.

[19]  G. Eslick,et al.  Alopecia and its association with coronary heart disease and cardiovascular risk factors: a meta-analysis. , 2014, International Journal of Cardiology.

[20]  P. Vokonas,et al.  Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events , 2014, International Journal of Obesity.

[21]  X. Estivill,et al.  Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index , 2014, International journal of endocrinology.

[22]  Suhuan Liu,et al.  Association of Serum Irisin with Metabolic Syndrome in Obese Chinese Adults , 2014, PloS one.

[23]  J. Martínez,et al.  Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women , 2014, American journal of human biology : the official journal of the Human Biology Council.

[24]  Mary T. Brinkoetter,et al.  Circulating irisin in relation to insulin resistance and the metabolic syndrome. , 2013, The Journal of clinical endocrinology and metabolism.

[25]  Zheng Chen,et al.  Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. , 2013, Journal of hepatology.

[26]  A. Swick,et al.  Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass. , 2013, Metabolism: clinical and experimental.

[27]  Jian-jun Liu,et al.  Lower circulating irisin is associated with type 2 diabetes mellitus. , 2013, Journal of diabetes and its complications.

[28]  I. Shimomura,et al.  Carotid ultrasonography: A potent tool for better clinical practice in diagnosis of atherosclerosis in diabetic patients , 2013, Journal of diabetes investigation.

[29]  B. Klapp,et al.  Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index , 2013, Peptides.

[30]  Peter K. Davidsen,et al.  Is irisin a human exercise gene? , 2012, Nature.

[31]  F. Candan,et al.  The association of insulin resistance and metabolic syndrome in early androgenetic alopecia. , 2010, Singapore medical journal.

[32]  Salvador Arias-Santiago,et al.  Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study. , 2010, Journal of the American Academy of Dermatology.

[33]  Lin-Hui Su,et al.  Association of androgenetic alopecia with metabolic syndrome in men: a community‐based survey , 2010, The British journal of dermatology.

[34]  J. Orava,et al.  Functional brown adipose tissue in healthy adults. , 2009, The New England journal of medicine.

[35]  N. Savaş,et al.  Is androgenetic alopecia a risk for atherosclerosis? , 2009, Journal of the European Academy of Dermatology and Venereology : JEADV.

[36]  H. Gabra,et al.  Antiestrogen Therapy Is Active in Selected Ovarian Cancer Cases: The Use of Letrozole in Estrogen Receptor–Positive Patients , 2007, Clinical Cancer Research.

[37]  R. Krauss,et al.  Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement , 2005, Current opinion in cardiology.

[38]  A. Hofman,et al.  Predictive Value of Noninvasive Measures of Atherosclerosis for Incident Myocardial Infarction: The Rotterdam Study , 2004, Circulation.

[39]  R. Dawber,et al.  Androgenetic alopecia in men and women. , 2001, Clinics in dermatology.

[40]  Ede Hüseyin,et al.  The relation between the severity of androgenetic alopecia and cardiovascular atherosclerosis measured via carotid intima-media thickness and the syntax score , 2016 .

[41]  F. Nuttall.  Body Mass Index , 2015, Nutrition today.

[42]  A. Erbay,et al.  Correlation of carotid intima media thickness and aortic stiffness index with androgenetic alopecia , 2015 .

[43]  H. Zartab,et al.  Classification and Scoring of Androgenetic Alopecia (Male and Female Pattern) , 2015 .