Role of ubiquitination in the regulation of plant defence against pathogens.

Ubiquitination is emerging as a common regulatory mechanism that controls a range of cellular processes in plants. Recent exciting discoveries from several laboratories suggest that ubiquitination may also play an important role in plant disease resistance. Several putative ubiquitin ligases have been identified as defence regulators. In addition, a combination of genetic screens and gene-silencing technologies has identified subunits and proposed regulators of SCF ubiquitin ligases as essential components of resistance (R)-gene-mediated resistance. Although no ubiquitin ligase targets that are associated with disease resistance have yet been identified in plants, there is evidence that this well-known protein-modification system may regulate plant defences against pathogens.

[1]  D. Xie,et al.  COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility. , 1998, Science.

[2]  Jonathan D. G. Jones,et al.  Regulatory Role of SGT1 in Early R Gene-Mediated Plant Defenses , 2002, Science.

[3]  K. Hammond-Kosack,et al.  Deciphering plant-pathogen communication: fresh perspectives for molecular resistance breeding. , 2003, Current opinion in biotechnology.

[4]  K. Hammond-Kosack,et al.  cDNA-AFLP Reveals a Striking Overlap in Race-Specific Resistance and Wound Response Gene Expression Profiles , 2000, Plant Cell.

[5]  S. Dinesh-Kumar,et al.  Tobacco Rar1, EDS1 and NPR1/NIM1 like genes are required for N-mediated resistance to tobacco mosaic virus. , 2002, The Plant journal : for cell and molecular biology.

[6]  Jonathan D. G. Jones,et al.  Arabidopsis RAR1 Exerts Rate-Limiting Control of R Gene–Mediated Defenses against Multiple Pathogens Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001040. , 2002, The Plant Cell Online.

[7]  T. Eulgem,et al.  Arabidopsis SGT1b Is Required for Defense Signaling Conferred by Several Downy Mildew Resistance Genes Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001123. , 2002, The Plant Cell Online.

[8]  Jonathan D. G. Jones,et al.  Plant pathogens and integrated defence responses to infection , 2001, Nature.

[9]  B. Thomma,et al.  Separate jasmonate-dependent and salicylate-dependent defense-response pathways in Arabidopsis are essential for resistance to distinct microbial pathogens. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Takeshi Noda,et al.  A ubiquitin-like system mediates protein lipidation , 2000, Nature.

[11]  Jonathan D. G. Jones,et al.  Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[12]  S. Elledge,et al.  Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex , 2002, Nature.

[13]  K. Shirasu,et al.  The U-box protein family in plants. , 2001, Trends in plant science.

[14]  Alessandra Devoto,et al.  The Jasmonate Signal Pathway Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.000679. , 2002, The Plant Cell Online.

[15]  A. Valencia,et al.  p23 and HSP20/α‐crystallin proteins define a conserved sequence domain present in other eukaryotic protein families , 2002, FEBS letters.

[16]  S. Shiu,et al.  The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[17]  E. Logemann,et al.  A highly specific pathogen-responsive promoter element from the immediate-early activated CMPG1 gene in Petroselinum crispum. , 2001, The Plant journal : for cell and molecular biology.

[18]  K. Gould,et al.  Structural insights into the U-box, a domain associated with multi-ubiquitination , 2003, Nature Structural Biology.

[19]  Ken Shirasu,et al.  RAR1 and NDR1 Contribute Quantitatively to Disease Resistance in Arabidopsis, and Their Relative Contributions Are Dependent on the R Gene Assayed Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001032. , 2002, The Plant Cell Online.

[20]  Hong Ma,et al.  The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. , 2002, The Plant cell.

[21]  R. Creelman,et al.  Jasmonate is essential for insect defense in Arabidopsis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[22]  X. Deng,et al.  Role of SCF Ubiquitin-Ligase and the COP9 Signalosome in the N Gene–Mediated Resistance Response to Tobacco mosaic virus Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.002493. , 2002, The Plant Cell Online.

[23]  X. Dong,et al.  Genetic dissection of systemic acquired resistance. , 2001, Current opinion in plant biology.

[24]  J. Turner,et al.  Protein complexes mediate signalling in plant responses to hormones, light, sucrose and pathogens , 2002, Plant Molecular Biology.

[25]  P. Guzmán,et al.  Early elicitor induction in members of a novel multigene family coding for highly related RING-H2 proteins in Arabidopsis thaliana , 1999, Plant Molecular Biology.

[26]  W. Gray,et al.  Arabidopsis SGT1b is required for SCF(TIR1)-mediated auxin response. , 2003, The Plant cell.

[27]  K. Hahlbrock,et al.  Two immediate-early pathogen-responsive members of the AtCMPG gene family in Arabidopsis thaliana and the W-box-containing elicitor-response element of AtCMPG1 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[28]  P. Schulze-Lefert,et al.  Regulators of cell death in disease resistance , 2000, Plant Molecular Biology.

[29]  C. Pickart,et al.  Ubiquitin enters the new millennium. , 2001, Molecular cell.

[30]  P. Schulze-Lefert,et al.  Complex formation, promiscuity and multi-functionality: protein interactions in disease-resistance pathways. , 2003, Trends in plant science.

[31]  A. Shevchenko,et al.  Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome , 2001, Science.

[32]  L. Aravind,et al.  Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1 , 2002, Science.

[33]  Ken Shirasu,et al.  The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance , 2002, Science.

[34]  A. Ciechanover,et al.  The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. , 2002, Physiological reviews.

[35]  M. Tyers,et al.  The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. , 1999, Progress in biophysics and molecular biology.

[36]  A. Weissman.  Ubiquitin and proteasomes: Themes and variations on ubiquitylation , 2001, Nature Reviews Molecular Cell Biology.

[37]  P. Schulze-Lefert,et al.  A Novel Class of Eukaryotic Zinc-Binding Proteins Is Required for Disease Resistance Signaling in Barley and Development in C. elegans , 1999, Cell.

[38]  C. Schwechheimer,et al.  COP9 signalosome revisited: a novel mediator of protein degradation. , 2001, Trends in cell biology.

[39]  J. Garin,et al.  Identification of Components of the Murine Histone Deacetylase 6 Complex: Link between Acetylation and Ubiquitination Signaling Pathways , 2001, Molecular and Cellular Biology.

[40]  J. Dangl,et al.  Common and Contrasting Themes of Plant and Animal Diseases , 2001, Science.

[41]  S. Elledge,et al.  SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. , 1999, Molecular cell.

[42]  T. Köcher,et al.  Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[43]  K. Shirasu,et al.  “To degrade or not to degrade?”—the emerging question in plant disease resistance , 2002 .

[44]  W. D. de Jong,et al.  The Small Heat-shock Protein αB-Crystallin Promotes FBX4-dependent Ubiquitination* , 2003, The Journal of Biological Chemistry.

[45]  S. Jentsch,et al.  A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly , 1999, Cell.

[46]  A. Nakano,et al.  EL5, a rice N-acetylchitooligosaccharide elicitor-responsive RING-H2 finger protein, is a ubiquitin ligase which functions in vitro in co-operation with an elicitor-responsive ubiquitin-conjugating enzyme, OsUBC5b. , 2002, The Plant journal : for cell and molecular biology.

[47]  C. Schwechheimer,et al.  Multiple Ubiquitin Ligase–Mediated Processes Require COP9 Signalosome and AXR1 Function Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.003434. , 2002, The Plant Cell Online.

[48]  M. Coleman,et al.  COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis. , 2002, The Plant journal : for cell and molecular biology.

[49]  T. Delaney,et al.  Arabidopsis SON1 Is an F-Box Protein That Regulates a Novel Induced Defense Response Independent of Both Salicylic Acid and Systemic Acquired Resistance Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001867. , 2002, The Plant Cell Online.

[50]  R. Guérois,et al.  Sgt1p Contributes to Cyclic AMP Pathway Activity and Physically Interacts with the Adenylyl Cyclase Cyr1p/Cdc35p in Budding Yeast , 2002, Eukaryotic Cell.