Role of electrostatic interactions during protein ultrafiltration.

A number of studies over the last decade have clearly demonstrated the importance of electrostatic interactions on the transport of charged proteins through semipermeable ultrafiltration membranes. This paper provides a review of recent developments in this field with a focus on the role of both protein and membrane charge on the rate of protein transport. Experimental results are analyzed using available theoretical models developed from the solution of the Poisson-Boltzmann equation for the partitioning of a charged particle into a charged pore. The potential of exploiting these electrostatic interactions for selective protein separations and for the development of ultrafiltration membranes with enhanced performance characteristics is also examined.

[1]  Zydney,et al.  Charge Regulation and Electrostatic Interactions for a Spherical Particle in a Cylindrical Pore , 1997, Journal of colloid and interface science.

[2]  R Kuriyel,et al.  High performance tangential flow filtration. , 1997, Biotechnology and bioengineering.

[3]  Carmay Lim,et al.  Principles governing Mg, Ca, and Zn binding and selectivity in proteins. , 2003, Chemical reviews.

[4]  A. Zydney,et al.  Effect of ion binding on protein transport through ultrafiltration membranes. , 1999 .

[5]  A. Zydney,et al.  Controlling protein transport in ultrafiltration using small charged ligands. , 2005, Biotechnology and bioengineering.

[6]  G. Belfort,et al.  Intermolecular forces between proteins and polymer films with relevance to filtration , 1997 .

[7]  A. Zydney,et al.  Determination of effective protein charge by capillary electrophoresis: effects of charge regulation in the analysis of charge ladders. , 2000, Analytical chemistry.

[8]  Shuichi Yamamoto,et al.  Resolution and Retention of Proteins near Isoelectric Points in Ion-Exchange Chromatography. Molecular Recognition in Electrostatic Interaction Chromatography , 2000 .

[9]  R. van Reis,et al.  Application of high‐performance tangential flow filtration (HPTFF) to the purification of a human pharmaceutical antibody fragment expressed in Escherichia coli , 2008, Biotechnology and bioengineering.

[10]  A. Zydney,et al.  Effect of Membrane Charge on Flow and Protein Transport during Ultrafiltration , 2006, Biotechnology progress.

[11]  W. Deen,et al.  Electrostatic and electrokinetic effects on hindered convection in pores. , 2009, Journal of colloid and interface science.

[12]  C R Robertson,et al.  Permselectivity of the glomerular capillary wall: III. Restricted transport of polyanions. , 1975, Kidney international.

[13]  Shoji Kimura,et al.  Separation of proteins by charged ultrafiltration membranes , 1988 .

[14]  A. Zydney,et al.  Effect of solution pH on protein transport through ultrafiltration membranes , 1999, Biotechnology and bioengineering.

[15]  William K. Wang.  Membrane separations in biotechnology , 2001 .

[16]  A. J. Rutgers,et al.  Researches on electro-endosmosis , 1945 .

[17]  A. Zydney,et al.  Effect of surface charge distribution on protein transport through semipermeable ultrafiltration membranes , 2009 .

[18]  A. Zydney,et al.  Separation of Protein Charge Variants by Ultrafiltration , 2008, Biotechnology progress.

[19]  M. Nyström,et al.  Modification of polysulfone ultrafiltration membranes with UV irradiation and hydrophilicity increasing agents , 1991 .

[20]  A. Zydney.  Membrane technology for purification of therapeutic proteins. , 2009, Biotechnology and bioengineering.

[21]  A. Zydney,et al.  Measurement of protein charge and ion binding using capillary electrophoresis. , 1998, Analytical chemistry.

[22]  Frank G. Smith,et al.  Electrostatic effects on the partitioning of spherical colloids between dilute bulk solution and cylindrical pores , 1983 .

[23]  A. Zydney,et al.  Separation of PEGylated α‐Lactalbumin from Unreacted Precursors and Byproducts Using Ultrafiltration , 2007, Biotechnology progress.

[24]  W. Potter,et al.  Electrochemical Properties of a Cation‐Transfer Membrane , 1957 .

[25]  F. Regnier,et al.  Retention model for high-performance ion-exchange chromatography☆ , 1983 .

[26]  S. Chan,et al.  Exploration of ionic modification in dual‐layer hollow fiber membranes for long‐term high‐performance protein separation , 2009 .

[27]  A. Zydney,et al.  Use of protein charge ladders to study electrostatic interactions during protein ultrafiltration , 2004, Biotechnology and bioengineering.

[28]  Ralf Kuriyel,et al.  High-performance tangential flow filtration: a highly selective membrane separation process , 2002 .

[29]  A. Zydney,et al.  Effect of solution pH and ionic strength on the separation of albumin from immunoglobulins (IgG) by selective filtration , 1994, Biotechnology and bioengineering.

[30]  Andrew L. Zydney,et al.  Bioprocess membrane technology , 2007 .

[31]  Vicki Chen,et al.  The use of anionic surfactants for reducing fouling of ultrafiltration membranes: their effects and optimization , 1992 .

[32]  A. Zydney,et al.  Effect of solution pH on protein transmission and membrane capacity during virus filtration , 2008, Biotechnology and bioengineering.

[33]  A. Zydney,et al.  Protein fractionation using electrostatic interactions in membranel filtration. , 1995, Biotechnology and bioengineering.

[34]  J. Carbeck,et al.  Effects of Cooperativity in Proton Binding on the Net Charge of Proteins in Charge Ladders , 2003 .

[35]  F. Hofmeister.  Zur Lehre von der Wirkung der Salze , 1888, Archiv für experimentelle Pathologie und Pharmakologie.

[36]  Douglas B. Burns,et al.  Buffer effects on the zeta potential of ultrafiltration membranes , 2000 .

[37]  A. Zydney,et al.  Electrostatic and electrokinetic interactions during protein transport through narrow pore membranes , 1994 .

[38]  A. Zydney,et al.  Membrane separations in biotechnology. , 2001, Current opinion in biotechnology.

[39]  John L. Anderson,et al.  Hindered diffusion of particles through small pores , 1978 .

[40]  S. Nagaoka,et al.  Charged ultrafiltration membrane for permeation of proteins , 1988 .

[41]  Robert Langer,et al.  High-throughput membrane surface modification to control NOM fouling. , 2009, Environmental science & technology.

[42]  G. Whitesides,et al.  Synthesis of monodisperse polymers from proteins. , 2003, Journal of the American Chemical Society.

[43]  B. Chaufer,et al.  Protein retention with modified and unmodified inorganic ultrafiltration membranes: model of ionic strength controlled retention , 1995 .

[44]  Andrew L. Zydney,et al.  High-performance tangential flow filtration using charged membranes , 1999 .

[45]  Andrew L. Zydney,et al.  Permeability and selectivity analysis for ultrafiltration membranes , 2005 .

[46]  S. Kubik.  Amino acid containing anion receptors. , 2009, Chemical Society reviews.

[47]  A. Zydney,et al.  Effect of spacer arm length on the performance of charge-modified ultrafiltration membranes , 2008 .

[48]  Frank G. Smith,et al.  Electrostatic double-layer interactions for spherical colloids in cylindrical pores , 1980 .

[49]  B. Van der Bruggen,et al.  Chemical modification of polyethersulfone nanofiltration membranes: A review , 2009 .

[50]  Andrew L. Zydney,et al.  Microfiltration and Ultrafiltration: Principles and Applications , 1996 .