Differences in the Expression of Heat-Shock Proteins and Antioxidant Enzymes between Human and Rodent Pancreatic Islets: Implications for the Pathogenesis of Insulin-Dependent Diabetes Mellitus

[1]  N. Morgan,et al.  Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis , 1994, Bioscience reports.

[2]  N. Welsh,et al.  Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M L Tomaro,et al.  Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. , 1994, Biochimica et biophysica acta.

[4]  N. Welsh,et al.  Protective action by hemin against interleukin-1β induced inhibition of rat pancreatic islet function , 1994, Molecular and Cellular Endocrinology.

[5]  J. Nerup,et al.  Nicotinamide Prevents Interleukin-1 Effects on Accumulated Insulin Release and Nitric Oxide Production in Rat Islets of Langerhans , 1994, Diabetes.

[6]  N. Welsh,et al.  Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. , 1994, The Journal of clinical investigation.

[7]  Bruce A. Yankner,et al.  Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus , 1994, Nature.

[8]  M. Maines,et al.  Coordinated expression and mechanism of induction of HSP32 (heme oxygenase-1) mRNA by hyperthermia in rat organs. , 1994, Biochimica et biophysica acta.

[9]  R. Tyrrell,et al.  Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[10]  F. Pociot,et al.  Polymorphic Analysis of the Human MHC‐Linked Heat Shock Protein 70 (HSP70‐2) and HSP70‐Hom Genes in Insulin‐Dependent Diabetes Mellitus (IDDM) , 1993, Scandinavian journal of immunology.

[11]  J. Palmer,et al.  Repair of Pancreatic β-cells: A Relevant Phenomenon in Early IDDM? , 1993, Diabetes.

[12]  P. Rorsman,et al.  Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes. , 1993, Science.

[13]  A. Peck,et al.  Antioxidant enzyme activities in IDD-prone and IDD-resistant mice: a comparative study. , 1993, Free radical biology & medicine.

[14]  G. Korbutt,et al.  Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. , 1992, The Journal of clinical investigation.

[15]  E. Cagliero,et al.  Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets. , 1992, Endocrinology.

[16]  L. Larsson,et al.  Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells. , 1992, Blood.

[17]  Suzanne Cory,et al.  bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship , 1991, Cell.

[18]  N. Welsh,et al.  Liposomal Delivery of Purified Heat Shock Protein hsp70 Into Rat Pancreatic Islets as Protection Against Interleukin 1β–Induced Impaired β-Cell Function , 1991, Diabetes.

[19]  D. Mason,et al.  Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. , 1990, The American journal of pathology.

[20]  N. Welsh,et al.  In vitro restoration of insulin production in islets from adult rats treated neonatally with streptozotocin. , 1990, Endocrinology.

[21]  Y. Tsujimoto Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell. , 1989, Oncogene.

[22]  B. Fanburg,et al.  Regulation of cellular glutathione. , 1989, The American journal of physiology.

[23]  D. Shrieve,et al.  Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis. , 1988, The Journal of biological chemistry.

[24]  L. Borg,et al.  A spectrophotometric method for determination of catalase activity in small tissue samples. , 1988, Analytical biochemistry.

[25]  David L. Vaux,et al.  Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells , 1988, Nature.

[26]  G. Eisenbarth,et al.  Type I diabetes as a chronic autoimmune disease. , 1988, The Journal of diabetic complications.

[27]  R. Kingston,et al.  Multiple basal elements of a human hsp70 promoter function differently in human and rodent cell lines , 1987, Molecular and cellular biology.

[28]  G. Eisenbarth Type I diabetes mellitus. A chronic autoimmune disease. , 1986 .

[29]  D. Pipeleers,et al.  A new in vitro model for the study of pancreatic A and B cells. , 1985, Endocrinology.

[30]  W. Welch,et al.  Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides. , 1985, Molecular and cellular biology.

[31]  M. Morange,et al.  Spontaneous high expression of heat‐shock proteins in mouse embryonal carcinoma cells and ectoderm from day 8 mouse embryo. , 1983, The EMBO journal.

[32]  D. Pipeleers,et al.  Determinants of the selective toxicity of alloxan to the pancreatic B cell. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[33]  S. Marklund,et al.  CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. , 1981, The Biochemical journal.

[34]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[35]  N. Welsh,et al.  Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines. , 1994, Autoimmunity.

[36]  S. Lindquist,et al.  Interleukin-1 beta increases the biosynthesis of the heat shock protein hsp70 and selectively decreases the biosynthesis of five proteins in rat pancreatic islets. , 1991, Autoimmunity.

[37]  B. Margulis,et al.  The characterization and use of different antibodies against the hsp70 major heat shock protein family for the development of an immunoassay , 1991, Electrophoresis.

[38]  N. Welsh,et al.  Decrease in insulin-containing secretory granules and mitochondrial gene expression in mouse pancreatic islets maintained in culture following streptozotocin exposure , 1991, Virchows Archiv. B, Cell pathology including molecular pathology.

[39]  R. Stocker,et al.  Induction of haem oxygenase as a defence against oxidative stress. , 1990, Free radical research communications.

[40]  S. Lindquist The heat-shock response. , 1986, Annual review of biochemistry.

[41]  E. Craig,et al.  The Heat Shock Respons , 1985 .

[42]  E. Craig,et al.  The heat shock response. , 1985, CRC critical reviews in biochemistry.