Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro.

[1]  Y. Yazaki,et al.  Signal transduction pathways in normal human monocytes stimulated by cytokines and mediators: comparative study with normal human neutrophils or transformed cells and the putative roles in functionality and cell biology. , 1999, Experimental hematology.

[2]  P. Rutgeerts,et al.  Infliximab for the treatment of fistulas in patients with Crohn's disease. , 1999, The New England journal of medicine.

[3]  T. Huang,et al.  Activation of Kupffer cells and caspase-3 involved in rat hepatocyte apoptosis induced by endotoxin. , 1999, Journal of hepatology.

[4]  E. Keystone The role of tumor necrosis factor antagonism in clinical practice. , 1999, The Journal of rheumatology. Supplement.

[5]  J. Kremer,et al.  A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. , 1999, The New England journal of medicine.

[6]  C. McClain,et al.  Treatment with glutathione precursor decreases cytokine activity. , 1999, JPEN. Journal of parenteral and enteral nutrition.

[7]  A. Nanji,et al.  MECHANISMS OF HEPATIC INJURY IN ALCOHOLIC LIVER DISEASE , 1998 .

[8]  K. Mullen,et al.  POTENTIAL NEW THERAPIES FOR ALCOHOLIC LIVER DISEASE , 1998 .

[9]  N. Makhatadze Tumor necrosis factor locus: genetic organisation and biological implications. , 1998, Human immunology.

[10]  M. Luster,et al.  Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat , 1997, Hepatology.

[11]  S. Targan,et al.  A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease , 1997 .

[12]  Z. Spolarics Endotoxin stimulates gene expression of ROS-eliminating pathways in rat hepatic endothelial and Kupffer cells. , 1996, The American journal of physiology.

[13]  C. McClain,et al.  Differential regulation of manganese superoxide dismutase activity by alcohol and TNF in human hepatoma cells. , 1995, Archives of biochemistry and biophysics.

[14]  M. Zern,et al.  Vitamin E therapy of acute CCl4‐induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding , 1995, Hepatology.

[15]  H. Tsukamoto,et al.  Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease , 1995, Hepatology.

[16]  K. Schulze-Osthoff,et al.  Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes , 1995 .

[17]  R. Maier,et al.  Antioxidants attenuate endotoxin-induced activation of alveolar macrophages. , 1995, Surgery.

[18]  D. Bunout,et al.  Effects of long-term vitamin E supplementation in alcoholic cirrhotics. , 1995, Journal of the American College of Nutrition.

[19]  J. Dasta,et al.  Acetylcysteine as a Cytoprotective Antioxidant in Patients with Severe Sepsis: Potential New Use for an Old Drug , 1994, The Annals of pharmacotherapy.

[20]  H. K. Bojes,et al.  Inactivation of Kupffer cells prevents early alcohol‐induced liver injury , 1994, Hepatology.

[21]  T. Macdonald,et al.  Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease , 1994 .

[22]  C. McClain,et al.  Cytokines and Alcoholic Liver Disease , 1993, Seminars in liver disease.

[23]  H. Jaeschke,et al.  Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia. , 1993, The American journal of physiology.

[24]  C. McClain,et al.  Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. , 1992, The American journal of physiology.

[25]  C. McClain,et al.  Tumor necrosis factor in alcohol enhanced endotoxin liver injury. , 1992, Alcoholism, clinical and experimental research.

[26]  D. Laskin,et al.  Lipopolysaccharide treatment of rats alters antigen expression and oxidative metabolism in hepatic macrophages and endothelial cells , 1992, Hepatology.

[27]  D. Remick,et al.  Cytokines in Health and Disease , 1992 .

[28]  C. McClain,et al.  Increased plasma interleukin-6 concentrations in alcoholic hepatitis. , 1992, The Journal of laboratory and clinical medicine.

[29]  Y. Fukuda,et al.  Cytokines and liver disease. , 1991, Japanese journal of medicine.

[30]  E. S. Kimball Cytokines and Inflammation , 1991 .

[31]  P. Baeuerle,et al.  Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1. , 1991, The EMBO journal.

[32]  J. Nagakawa,et al.  Involvement of tumor necrosis factor-alpha in the pathogenesis of activated macrophage-mediated hepatitis in mice. , 1990, Gastroenterology.

[33]  J. Spitzer,et al.  Superoxide Anion Generation in the Liver During the Early Stage of Endotoxemia in Rats , 1990, Journal of leukocyte biology.

[34]  K. Tracey,et al.  The role of cytokine mediators in septic shock. , 1990, Advances in surgery.

[35]  G. Wong,et al.  Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor , 1989, Cell.

[36]  C. McClain,et al.  Increased tumor necrosis factor production by monocytes in alcoholic hepatitis , 1989, Hepatology.

[37]  A. Cerami,et al.  Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses , 1988, The Journal of cell biology.

[38]  T. Peters,et al.  The release of tumor necrosis factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin E2 and dexamethasone. , 1988, Journal of hepatology.

[39]  C. Nathan,et al.  Secretory products of macrophages. , 1987, The Journal of clinical investigation.

[40]  C. Bode,et al.  Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. , 1987, Journal of hepatology.

[41]  M. E. Carver,et al.  Serum-free in vitro bioassay for the detection of tumor necrosis factor. , 1986, Journal of immunological methods.

[42]  D. R. Wilson,et al.  Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro , 1986, The Journal of cell biology.

[43]  L. Seeff,et al.  Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. , 1984, The New England journal of medicine.

[44]  R. Roeder,et al.  Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. , 1983, Nucleic acids research.

[45]  B. Fleshler,et al.  The Liver: Biology and Pathobiology , 1983 .

[46]  Willis C. Maddrey,et al.  Corticosteroid therapy of alcoholic hepatitis. , 1978, Gastroenterology.