Carvedilol protection against endogenous Aβ-induced neurotoxicity in N2a cells

[1]  T. Best,et al.  The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer's Disease , 2015, Oxidative medicine and cellular longevity.

[2]  Rikang Wang,et al.  Carvedilol Attenuates 6-Hydroxydopamine-Induced Cell Death in PC12 Cells: Involvement of Akt and Nrf2/ARE Pathways , 2014, Neurochemical Research.

[3]  Li Yue-chun,et al.  Effects of carvedilol treatment on cardiac cAMP response element binding protein expression and phosphorylation in acute coxsackievirus B3-induced myocarditis , 2013, BMC Cardiovascular Disorders.

[4]  D. Offen,et al.  Cell and gene therapy in Alzheimer's disease. , 2013, Stem cells and development.

[5]  C. Pavlides,et al.  Carvedilol reestablishes long-term potentiation in a mouse model of Alzheimer's disease. , 2010, Journal of Alzheimer's disease : JAD.

[6]  P. Tang,et al.  Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease. , 2009, Free radical biology & medicine.

[7]  Robert C. Green,et al.  Effects of cardiovascular medications on rate of functional decline in Alzheimer disease. , 2008, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[8]  D. Butterfield,et al.  Mutations in amyloid precursor protein and presenilin‐1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid β‐peptide (1–42), H2O2 and kainic acid: implications for Alzheimer's disease , 2006, Journal of neurochemistry.

[9]  F. LaFerla,et al.  Alzheimer's disease: Aβ, tau and synaptic dysfunction , 2005 .

[10]  Santos,et al.  O carvedilol protege mitocôndrias cardíacas isquémicas de lesões induzidas por stress oxidativo , 2004 .

[11]  P. Oliveira,et al.  Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity. , 2004, Toxicology and applied pharmacology.

[12]  M. Mattson.  Pathways towards and away from Alzheimer's disease , 2004, Nature.

[13]  S. Ichinose,et al.  Amlodipine and carvedilol prevent cytotoxicity in cortical neurons isolated from stroke-prone spontaneously hypertensive rats. , 2004, Hypertension research : official journal of the Japanese Society of Hypertension.

[14]  P. Oliveira,et al.  Chenodeoxycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: protective role of carvedilol. , 2003, Mitochondrion.

[15]  D. Butterfield,et al.  Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. , 2001, Trends in molecular medicine.

[16]  A. Nunomura,et al.  Mitochondrial abnormalities in Alzheimer disease , 2000, Neurobiology of Aging.

[17]  D. Selkoe,et al.  Translating cell biology into therapeutic advances in Alzheimer's disease , 1999, Nature.

[18]  J C Reed,et al.  Mitochondria and apoptosis. , 1998, Science.

[19]  G. Perry,et al.  Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[20]  C. Cotman,et al.  Mechanisms of Neuronal Death in Alzheimer's Disease , 1996, Brain pathology.

[21]  J. Cohn,et al.  The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. , 1996, The New England journal of medicine.

[22]  D. Pollen,et al.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.

[23]  G. Feuerstein,et al.  Neuroprotective effects of carvedilol, a new antihypertensive, at the N-methyl-d-aspartate receptor , 1992, Neuroscience Letters.

[24]  J. Hardy,et al.  Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.

[25]  P. Reddy,et al.  Mitochondria-Targeted Molecules as Potential Drugs to Treat Patients With Alzheimer's Disease. , 2017, Progress in molecular biology and translational science.

[26]  Anil Kumar,et al.  Neuroprotective effect of carvedilol against aluminium induced toxicity: possible behavioral and biochemical alterations in rats , 2011, Pharmacological reports : PR.

[27]  P. Oliveira,et al.  Carvedilol inhibits the mitochondrial permeability transition by an antioxidant mechanism , 2007, Cardiovascular Toxicology.

[28]  R. Strosznajder,et al.  Effect of carvedilol on neuronal survival and poly(ADP-ribose) polymerase activity in hippocampus after transient forebrain ischemia. , 2005, Acta neurobiologiae experimentalis.

[29]  C. Oliveira,et al.  Carvedilol protects ischemic cardiac mitochondria by preventing oxidative stress. , 2004, Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.