Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System.

[1]  N. Rhind,et al.  Analysis of DNA Replication in Fission Yeast by Combing. , 2018, Cold Spring Harbor protocols.

[2]  A. Holland,et al.  A New Mode of Mitotic Surveillance. , 2017, Trends in cell biology.

[3]  Rebecca R. Beach,et al.  Aneuploidy Causes Non-genetic Individuality , 2017, Cell.

[4]  N. Rhind,et al.  Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA , 2017, bioRxiv.

[5]  Angelika Amon,et al.  Single-chromosome Gains Commonly Function as Tumor Suppressors. , 2017, Cancer cell.

[6]  S. Elledge,et al.  Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy , 2017, Science.

[7]  David J. Barry,et al.  APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. , 2017, Cancer discovery.

[8]  Nicolai J. Birkbak,et al.  BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer , 2017, Cancer cell.

[9]  T. Halazonetis,et al.  POLD3 Is Haploinsufficient for DNA Replication in Mice. , 2016, Molecular cell.

[10]  Ahwan Pandey,et al.  Trisomy 21 consistently activates the interferon response , 2016, eLife.

[11]  A. Amon,et al.  Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo , 2016, Genes & development.

[12]  Z. Dong,et al.  Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation , 2016, Nature Cell Biology.

[13]  Shiv D. Kale,et al.  Selective advantage of trisomic human cells cultured in non-standard conditions , 2016, Scientific Reports.

[14]  B. Kerem,et al.  The presence of extra chromosomes leads to genomic instability , 2016, Nature Communications.

[15]  Charles Boone,et al.  Chromosome-Specific and Global Effects of Aneuploidy in Saccharomyces cerevisiae , 2016, Genetics.

[16]  Peter J. Campbell,et al.  Chromothripsis and Kataegis Induced by Telomere Crisis , 2015, Cell.

[17]  Y. Liu,et al.  Replication stress activates DNA repair synthesis in mitosis , 2015, Nature.

[18]  A. Amon,et al.  Aneuploidy triggers a TFEB-mediated lysosomal stress response , 2015, Autophagy.

[19]  E. White,et al.  Aneuploidy-induced cellular stresses limit autophagic degradation , 2015, Genes & development.

[20]  A. Amon,et al.  Short- and long-term effects of chromosome mis-segregation and aneuploidy , 2015, Nature Reviews Molecular Cell Biology.

[21]  K. Iwata,et al.  Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells , 2015, Nature Communications.

[22]  Flore Kruiswijk,et al.  p53 in survival, death and metabolic health: a lifeguard with a licence to kill , 2015, Nature Reviews Molecular Cell Biology.

[23]  Matthew Meyerson,et al.  CHROMOTHRIPSIS FROM DNA DAMAGE IN MICRONUCLEI , 2015, Nature.

[24]  Jason M. Sheltzer,et al.  Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast , 2015, Molecular biology of the cell.

[25]  T. Schumacher,et al.  Neoantigens in cancer immunotherapy , 2015, Science.

[26]  Jitendra Kumar Meena,et al.  Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion , 2015, The EMBO journal.

[27]  Andrei Kucharavy,et al.  Targeting the Adaptability of Heterogeneous Aneuploids , 2015, Cell.

[28]  N. Hacohen,et al.  Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. , 2014, Cell reports.

[29]  A. Amon,et al.  Single cell sequencing reveals low levels of aneuploidy across mammalian tissues , 2014, Proceedings of the National Academy of Sciences.

[30]  C. Rice,et al.  Interferon-stimulated genes: a complex web of host defenses. , 2014, Annual review of immunology.

[31]  S. Elledge,et al.  Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome , 2013, Cell.

[32]  S. Lowe,et al.  p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells , 2013, The Journal of experimental medicine.

[33]  T. Deerinck,et al.  Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei , 2013, Cell.

[34]  Yun-chi Tang,et al.  Gene Copy-Number Alterations: A Cost-Benefit Analysis , 2013, Cell.

[35]  A. Amon,et al.  Aneuploidy causes proteotoxic stress in yeast. , 2012, Genes & development.

[36]  M. Mann,et al.  Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells , 2012, Molecular Systems Biology.

[37]  Maitreya J. Dunham,et al.  Transcriptional consequences of aneuploidy , 2012, Proceedings of the National Academy of Sciences.

[38]  N. Pavelka,et al.  Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast , 2012, PLoS genetics.

[39]  David Pellman,et al.  Causes and consequences of aneuploidy in cancer , 2012, Nature Reviews Genetics.

[40]  Neil J Ganem,et al.  DNA breaks and chromosome pulverization from errors in mitosis , 2012, Nature.

[41]  Prabhjot Kaur,et al.  Chromosomal Instability Substantiates Poor Prognosis in Patients with Diffuse Large B-cell Lymphoma , 2011, Clinical Cancer Research.

[42]  Xiaowo Wang,et al.  Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. , 2011, Genes & development.

[43]  R. Medema,et al.  Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations , 2011, Science.

[44]  Jason M. Sheltzer,et al.  Aneuploidy Drives Genomic Instability in Yeast , 2011, Science.

[45]  Nicolai J. Birkbak,et al.  Chromosomal instability confers intrinsic multidrug resistance. , 2011, Cancer research.

[46]  A. Amon,et al.  Identification of Aneuploidy-Selective Antiproliferation Compounds , 2011, Cell.

[47]  Antonella Isacchi,et al.  Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. , 2010, Cancer research.

[48]  G. Sluder,et al.  Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis , 2010, Current Biology.

[49]  Linjie Guo,et al.  The ATM–p53 pathway suppresses aneuploidy-induced tumorigenesis , 2010, Proceedings of the National Academy of Sciences.

[50]  Andrea Musacchio,et al.  Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine , 2010, The Journal of cell biology.

[51]  Stephen S. Taylor,et al.  Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex , 2010, The Journal of cell biology.

[52]  J. Campisi,et al.  Inflammatory networks during cellular senescence: causes and consequences. , 2010, Trends in molecular medicine.

[53]  Duane A. Compton,et al.  Proliferation of aneuploid human cells is limited by a p53-dependent mechanism , 2010, The Journal of cell biology.

[54]  A. Jauch,et al.  Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group , 2009, Journal of cellular and molecular medicine.

[55]  D. Raulet,et al.  Oncogenic stress sensed by the immune system: role of natural killer cell receptors , 2009, Nature Reviews Immunology.

[56]  D. Cleveland,et al.  Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis , 2009, Nature Reviews Molecular Cell Biology.

[57]  Angelika Amon,et al.  Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells , 2008, Science.

[58]  S. Lowe,et al.  Senescence of Activated Stellate Cells Limits Liver Fibrosis , 2008, Cell.

[59]  M. O’Driscoll Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders , 2008, Current genomics.

[60]  R. Houlston,et al.  Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis , 2008, Gut.

[61]  Makoto Kinoshita,et al.  [Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen]. , 2007, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

[62]  Maitreya J. Dunham,et al.  Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast , 2007, Science.

[63]  O. Niwa,et al.  Growth arrest and chromosome instability in aneuploid yeast , 2006, Yeast.

[64]  R. Reeves,et al.  Understanding the Basis for Down Syndrome Phenotypes , 2006, PLoS genetics.

[65]  Geert J. P. L. Kops,et al.  On the road to cancer: aneuploidy and the mitotic checkpoint , 2005, Nature Reviews Cancer.

[66]  J. Hodgkin Karyotype, ploidy, and gene dosage. , 2005, WormBook : the online review of C. elegans biology.

[67]  R. Kumar,et al.  BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice , 2004, Nature Genetics.

[68]  J. Avruch,et al.  Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. , 2001, Physiological reviews.

[69]  P. Hunt,et al.  To err (meiotically) is human: the genesis of human aneuploidy , 2001, Nature Reviews Genetics.

[70]  A. Libchaber,et al.  Elasticity and Structure of Eukaryote Chromosomes Studied by Micromanipulation and Micropipette Aspiration , 1997, The Journal of cell biology.

[71]  B. S. Baker,et al.  Segmental aneuploidy and the genetic gross structure of the Drosophila genome. , 1972, Genetics.

[72]  B. Chapuis,et al.  Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs. , 1968, Immunology.

[73]  Jitendra Kumar Meena,et al.  Telomerase abrogates aneuploidy‐induced telomere replication stress, senescence and cell depletion , 2017, The EMBO journal.

[74]  D. Lorke Developmental characteristics of trisomy 19 mice. , 1994, Acta anatomica.