Total sleep deprivation, chronic sleep restriction and sleep disruption.

Sleep loss may result from total sleep deprivation (such as a shift worker might experience), chronic sleep restriction (due to work, medical conditions or lifestyle) or sleep disruption (which is common in sleep disorders such as sleep apnea or restless legs syndrome). Total sleep deprivation has been widely researched, and its effects have been well described. Chronic sleep restriction and sleep disruption (also known as sleep fragmentation) have received less experimental attention. Recently, there has been increasing interest in sleep restriction and disruption as it has been recognized that they have a similar impact on cognitive functioning as a period of total sleep deprivation. Sleep loss causes impairments in cognitive performance and simulated driving and induces sleepiness, fatigue and mood changes. This review examines recent research on the effects of sleep deprivation, restriction and disruption on cognition and neurophysiologic functioning in healthy adults, and contrasts the similarities and differences between these three modalities of sleep loss.

[1]  L. Kim,et al.  Cognitive deterioration and changes of P300 during total sleep deprivation , 2003, Psychiatry and clinical neurosciences.

[2]  A. Williamson,et al.  Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication , 2000, Occupational and environmental medicine.

[3]  Peter A. Robinson,et al.  Unified neurophysical model of EEG spectra and evoked potentials , 2002, Biological Cybernetics.

[4]  A. Lash,et al.  The P300 event-related potential. The effects of sleep deprivation. , 1992, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[5]  D. Dinges,et al.  Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery. , 2010, Sleep.

[6]  T. Roth,et al.  Experimental sleep fragmentation in normal subjects. , 1987, The International journal of neuroscience.

[7]  W. Pritchard.  Psychophysiology of P300. , 1981, Psychological bulletin.

[8]  E. Gould,et al.  Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids , 2006, Proceedings of the National Academy of Sciences.

[9]  D Gounot,et al.  Where arousal meets attention: a simultaneous fMRI and EEG recording study , 2004, NeuroImage.

[10]  T. Balkin,et al.  Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills. , 2008, Sleep medicine.

[11]  D. Dawson,et al.  Fatigue, alcohol and performance impairment , 1997, Nature.

[12]  Peter Meerlo,et al.  New neurons in the adult brain: the role of sleep and consequences of sleep loss. , 2009, Sleep medicine reviews.

[13]  M. Kryger,et al.  Principles and Practice of Sleep Medicine , 1989 .

[14]  M H Bonnet,et al.  Performance and sleepiness as a function of frequency and placement of sleep disruption. , 1986, Psychophysiology.

[15]  D. Murray,et al.  The effect of sleep disruption on performance of anaesthetists – A pilot study * , 2003, Anaesthesia.

[16]  R. Sapolsky,et al.  Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning. , 2005, Journal of neurophysiology.

[17]  Maria L. Thomas,et al.  Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose‐response study , 2003, Journal of sleep research.

[18]  L R Hartley,et al.  A Comparison of Continuous and Distributed Reduced Sleep Schedules , 1974, The Quarterly journal of experimental psychology.

[19]  S. Doran,et al.  Sustained attention performance during sleep deprivation: evidence of state instability. , 2001, Archives italiennes de biologie.

[20]  C. Czeisler,et al.  Healthy Older Adults Better Tolerate Sleep Deprivation Than Young Adults , 2009, Journal of the American Geriatrics Society.

[21]  T. Roth,et al.  Fragmenting sleep diminishes its recuperative value. , 1987, Sleep.

[22]  M. Carskadon,et al.  Cumulative effects of sleep restriction on daytime sleepiness. , 1981, Psychophysiology.

[23]  E. Wolpert.  A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. , 1969 .

[24]  A. Maclean,et al.  How do prolonged wakefulness and alcohol compare in the decrements they produce on a simulated driving task? , 2001, Accident; analysis and prevention.

[25]  D. Dinges,et al.  Chapter 6 – Chronic Sleep Deprivation , 2005 .

[26]  G. Barbato,et al.  Conservation of photoperiod-responsive mechanisms in humans. , 1993, The American journal of physiology.

[27]  M H Bonnet,et al.  Effect of sleep disruption on sleep, performance, and mood. , 1985, Sleep.

[28]  C. Guilleminault,et al.  Sleep fragmentation in normals: a model for sleepiness associated with upper airway resistance syndrome. , 1994, Sleep.

[29]  J. Pilcher,et al.  Effects of sleep deprivation on performance: a meta-analysis. , 1996, Sleep.

[30]  P Achermann,et al.  Dual electroencephalogram markers of human sleep homeostasis: correlation between theta activity in waking and slow-wave activity in sleep , 2000, Neuroscience.

[31]  M. Bonnet,et al.  Clinical effects of sleep fragmentation versus sleep deprivation. , 2003, Sleep medicine reviews.

[32]  S. Muecke,et al.  Effects of rotating night shifts: literature review. , 2005, Journal of advanced nursing.

[33]  R. Knight,et al.  Role of human prefrontal cortex in attention control. , 1995, Advances in neurology.

[34]  A. Rechtschaffen.  A manual of standardized terminology, techniques and scoring system for sleep of human subjects , 1968 .

[35]  H. Haas,et al.  Sleep Deprivation Increases A1 Adenosine Receptor Binding in the Human Brain: A Positron Emission Tomography Study , 2007, The Journal of Neuroscience.

[36]  M. Bertini,et al.  The effects of slow-wave sleep (SWS) deprivation and time of night on behavioral performance upon awakening , 1999, Physiology & Behavior.

[37]  J. Hobson,et al.  The prefrontal cortex in sleep , 2002, Trends in Cognitive Sciences.

[38]  G. Patrick,et al.  Studies from the psychological laboratory of the University of Iowa: On the effects of loss of sleep , 1896 .

[39]  Herbert Heuer,et al.  The Effects of Total Sleep Deprivation on the Generation of Random Sequences of Key-Presses, Numbers and Nouns , 2005, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[40]  Mathias Basner,et al.  Aircraft noise effects on sleep: application of the results of a large polysomnographic field study. , 2006, The Journal of the Acoustical Society of America.

[41]  J A Horne,et al.  One night of sleep loss impairs innovative thinking and flexible decision making. , 1999, Organizational behavior and human decision processes.

[42]  T J Balkin,et al.  Does sleep fragmentation impact recuperation?A review and reanalysis , 1999, Journal of sleep research.

[43]  D. Dinges,et al.  Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability. , 2004, Sleep.

[44]  P. Meerlo,et al.  Sleep restriction by forced activity reduces hippocampal cell proliferation , 2005, Brain Research.

[45]  D. Bates,et al.  Effect of reducing interns' work hours on serious medical errors in intensive care units. , 2004, The New England journal of medicine.

[46]  Siobhan Banks,et al.  Low levels of alcohol impair driving simulator performance and reduce perception of crash risk in partially sleep deprived subjects. , 2004, Sleep.

[47]  T. Monk.  Sleep, sleepiness, and performance , 1991 .

[48]  J. Mullington,et al.  Sustained sleep restriction reduces emotional and physical well-being , 2005, Pain.

[49]  C. Degueldre,et al.  Are Spatial Memories Strengthened in the Human Hippocampus during Slow Wave Sleep? , 2004, Neuron.

[50]  Stephen H. Fairclough,et al.  Impairment of Driving Performance Caused by Sleep Deprivation or Alcohol: A Comparative Study , 1999, Hum. Factors.

[51]  T. Roth,et al.  Experimental sleep fragmentation. , 1994, Sleep.

[52]  D. Dinges,et al.  Performing while sleepy: Effects of experimentally-induced sleepiness. , 1991 .

[53]  N. Kleitman,et al.  Sleep and Wakefulness , 1965 .

[54]  Miguel Angel Guevara,et al.  Amplitude reduction in visual event-related potentials as a function of sleep deprivation. , 1999, Sleep.

[55]  M. Bonnet.  The effect of sleep fragmentation on sleep and performance in younger and older subjects , 1989, Neurobiology of Aging.

[56]  D. Dinges,et al.  Behavioral and physiological consequences of sleep restriction. , 2007, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[57]  C. Guilleminault,et al.  A Comparative Model: Reaction Time Performance in Sleep‐Disordered Breathing Versus Alcohol‐Impaired Controls , 1999, The Laryngoscope.

[58]  I. Deary,et al.  Effects of sleep disruption on cognitive performance and mood in medical house officers. , 1987, British medical journal.

[59]  L A Reyner,et al.  Driving impairment due to sleepiness is exacerbated by low alcohol intake , 2003, Occupational and environmental medicine.

[60]  M. Kerkhofs,et al.  Age modulates the effects of sleep restriction in women. , 2005, Sleep.

[61]  P Badia,et al.  Effects of experimentally-induced sleep fragmentation on sleep and sleepiness. , 1987, Psychophysiology.

[62]  David F. Dinges,et al.  Microcomputer analyses of performance on a portable, simple visual RT task during sustained operations , 1985 .

[63]  M. Mitler,et al.  Maintenance of wakefulness test: a polysomnographic technique for evaluation treatment efficacy in patients with excessive somnolence. , 1982, Electroencephalography and clinical neurophysiology.

[64]  Mathias Basner,et al.  Effects of nocturnal aircraft noise on cognitive performance in the following morning: dose–response relationships in laboratory and field , 2010, International archives of occupational and environmental health.

[65]  D. Dinges,et al.  Neurocognitive Consequences of Sleep Deprivation , 2005, Seminars in neurology.

[66]  D Lehmann,et al.  Sleep deprivation: effect on sleep stages and EEG power density in man. , 1981, Electroencephalography and clinical neurophysiology.

[67]  D. Dinges,et al.  The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. , 2003, Sleep.

[68]  David F Neri,et al.  Fatigue countermeasures in aviation. , 2009, Aviation, space, and environmental medicine.

[69]  D. Dinges,et al.  Chapter 6 – Chronic Sleep Deprivation , 2005 .

[70]  J. Horne,et al.  The impact of sleep deprivation on decision making: a review. , 2000, Journal of experimental psychology. Applied.

[71]  M. Bonnet.  Infrequent periodic sleep disruption: Effects on sleep, performance and mood , 1989, Physiology & Behavior.

[72]  A Pfefferbaum,et al.  Event-related potentials and eyeblink responses in automatic and controlled processing: effects of age. , 1991, Electroencephalography and clinical neurophysiology.

[73]  P. Meerlo,et al.  Hippocampal cell proliferation across the day: Increase by running wheel activity, but no effect of sleep and wakefulness , 2006, Behavioural Brain Research.

[74]  J. Horne,et al.  Vehicle accidents related to sleep: a review. , 1999, Occupational and environmental medicine.

[75]  T. W. Boonstra,et al.  Effects of sleep deprivation on event-related fields and alpha activity during rhythmic force production , 2005, Neuroscience Letters.

[76]  M. Bonnet,et al.  Performance and sleepiness following moderate sleep disruption and slow wave sleep deprivation , 1986, Physiology & Behavior.

[77]  Dennis McGinty,et al.  Sleep deprivation suppresses neurogenesis in the adult hippocampus of rats , 2005, The European journal of neuroscience.

[78]  R. McCarley,et al.  Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. , 1997, Science.

[79]  Gregory G. Brown,et al.  The Effects of Total Sleep Deprivation on Cerebral Responses to Cognitive Performance , 2001, Neuropsychopharmacology.

[80]  N J Douglas,et al.  The effect of sleep fragmentation on daytime function. , 1996, American journal of respiratory and critical care medicine.

[81]  G. Belenky,et al.  Investigating the temporal dynamics and underlying mechanisms of cognitive fatigue. , 2011 .

[82]  Joshua J Gooley,et al.  Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback , 2006, Journal of biological rhythms.

[83]  M. Carskadon,et al.  The multiple sleep latency test: what does it measure? , 1982, Sleep.

[84]  A. Pack,et al.  Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night. , 1997, Sleep.

[85]  S. Hursh,et al.  Chapter 67 – Fatigue, Performance, Errors, and Accidents , 2010 .