Molecularly Imprinted Polymer-Coated Quartz Crystal Microbalance for Detection of Biological Hormone

A piezoelectric sensor with a molecularly imprinted synthetic polymer receptor was developed. A plant hormone, indole-3-acetic acid (IAA) was used as the model target molecule, and an IAA-imprinted polymer was coated onto a 9 MHz AT-cut quartz crystal microbalance. The sensor showed a selective response and gave a linear relationship between frequency shift and amount of IAA in the range from 10 to 200 nmol.

[1]  K. Mosbach,et al.  A Biomimetic Sensor Based on a Molecularly Imprinted Polymer as a Recognition Element Combined with Fiber-Optic Detection , 1995 .

[2]  Kenji Yokoyama,et al.  Highly sensitive quartz crystal immunosensors for multisample detection of herbicides , 1995 .

[3]  Y. Okahata,et al.  Detection of bioactive compounds using a lipid-coated quartz-crystal microbalance , 1992 .

[4]  Klaus Mosbach,et al.  Drug assay using antibody mimics made by molecular imprinting , 1993, Nature.

[5]  Toshifumi Takeuchi,et al.  A molecularly imprinted synthetic polymer receptor selective for atrazine , 1995 .

[6]  I. Karube,et al.  Recognition in Novel Molecularly Imprinted Polymer Sialic Acid Receptors in Aqueous Media , 1996 .

[7]  J. Matsui Molecularly imprinted receptor having metalloporphyrin-based signaling binding site , 1998 .

[8]  G. Wulff Molecular Imprinting in Cross‐Linked Materials with the Aid of Molecular Templates— A Way towards Artificial Antibodies , 1995 .

[9]  K. Shea,et al.  Designed catalysts. A synthetic network polymer that catalyzes the dehydrofluorination of 4-fluoro-4-(p-nitrophenyl)butan-2-one , 1994 .

[10]  F. Caruso,et al.  Quartz crystal microbalance study of DNA immobilization and hybridization for nucleic Acid sensor development. , 1997, Analytical chemistry.

[11]  T. Takeuchi,et al.  Effects of 2-Hydroxyethyl Methacrylate on Polymer Network and Interaction in Hydrophilic Molecularly Imprinted Polymers , 1999 .

[12]  J. Matsui,et al.  Molecular imprinting: An approach to “tailor-made” synthetic polymers with biomimetic functions , 1996 .

[13]  C. Malitesta,et al.  Molecularly imprinted electrosynthesized polymers:  new materials for biomimetic sensors. , 1999, Analytical chemistry.

[14]  Izumi Ichinose,et al.  Molecular Imprinting of Azobenzene Carboxylic Acid on a TiO2 Ultrathin Film by the Surface Sol-Gel Process , 1998 .

[15]  Peter A. Lieberzeit,et al.  Molecular imprinting in chemical sensing – Detection of aromatic and halogenated hydrocarbons as well as polar solvent vapors , 1998 .