Aggregation and interaction of cationic nanoparticles on bacterial surfaces.

Cationic monolayer-protected gold nanoparticles (AuNPs) with sizes of 6 or 2 nm interact with the cell membranes of Escherichia coli (Gram-) and Bacillus subtilis (Gram+), resulting in the formation of strikingly distinct AuNP surface aggregation patterns or lysis depending upon the size of the AuNPs. The aggregation phenomena were investigated by transmission electron microscopy and UV-vis spectroscopy. Upon proteolytic treatment of the bacteria, the distinct aggregation patterns disappeared.

[1]  Keith E Maier,et al.  Growth inhibition of Staphylococcus aureus by mixed monolayer gold nanoparticles. , 2011, Small.

[2]  Xingyu Jiang,et al.  Small molecule-capped gold nanoparticles as potent antibacterial agents that target Gram-negative bacteria. , 2010, Journal of the American Chemical Society.

[3]  Vincent M Rotello,et al.  Gold nanoparticle-fluorophore complexes: sensitive and discerning "noses" for biosystems sensing. , 2010, Angewandte Chemie.

[4]  D. Sasaki,et al.  Steric confinement of proteins on lipid membranes can drive curvature and tubulation , 2010, Proceedings of the National Academy of Sciences.

[5]  Wei Wang,et al.  Biotemplated Synthesis of Gold Nanoparticle–Bacteria Cellulose Nanofiber Nanocomposites and Their Application in Biosensing , 2010 .

[6]  Vincent M. Rotello,et al.  Enzyme-amplified array sensing of proteins in solution and in biofluids. , 2010, Journal of the American Chemical Society.

[7]  Subinoy Rana,et al.  Nanoparticles for detection and diagnosis. , 2010, Advanced drug delivery reviews.

[8]  Mustafa Culha,et al.  Layer-by-layer coating of bacteria with noble metal nanoparticles for surface-enhanced Raman scattering , 2009, Analytical and bioanalytical chemistry.

[9]  Vincent M Rotello,et al.  Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays , 2009, Proceedings of the National Academy of Sciences.

[10]  Vincent M Rotello,et al.  Rapid and efficient identification of bacteria using gold-nanoparticle-poly(para-phenyleneethynylene) constructs. , 2008, Angewandte Chemie.

[11]  Kristen N. Duthie,et al.  Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. , 2008, Nano letters.

[12]  Seungpyo Hong,et al.  Nanoparticle interaction with biological membranes: does nanotechnology present a Janus face? , 2007, Accounts of chemical research.

[13]  Vincent M Rotello,et al.  Detection and identification of proteins using nanoparticle-fluorescent polymer 'chemical nose' sensors. , 2007, Nature nanotechnology.

[14]  T. C. Barnett,et al.  Surface proteins of gram-positive bacteria and how they get there. , 2006, Annual review of microbiology.

[15]  Yonghong He,et al.  Bacillus subtilis assisted assembly of gold nanoparticles into long conductive nodous ribbons. , 2006, The journal of physical chemistry. B.

[16]  Vikas Berry,et al.  Deposition of CTAB-terminated nanorods on bacteria to form highly conducting hybrid systems. , 2005, Journal of the American Chemical Society.

[17]  Chad A Mirkin,et al.  Nanostructures in biodiagnostics. , 2005, Chemical reviews.

[18]  D. Astruc,et al.  Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. , 2004, Chemical reviews.

[19]  V. Rotello,et al.  Nanoparticles: scaffolds and building blocks. , 2003, Accounts of chemical research.

[20]  S. Hasegawa,et al.  Heat‐Induced Size Evolution of Gold Nanoparticles in the Solid State , 2001 .

[21]  Chad A. Mirkin,et al.  Programmed Materials Synthesis with DNA. , 1999, Chemical reviews.

[22]  R. Murray,et al.  Dynamics of Place-Exchange Reactions on Monolayer-Protected Gold Cluster Molecules , 1999 .

[23]  Mathias Brust,et al.  Synthesis of thiol-derivatised gold nanoparticles in a two-phase liquid-liquid system , 1994 .