Limitaciones del blush miocárdico para el análisis de la perfusión miocárdica en pacientes con infarto agudo de miocardio y flujo TIMI 3

Introduccion y objetivos Analizamos la variabilidad en la medicion del indice angiografico de blush entre un hospital universitario y un laboratorio central independiente, asi como su correlacion con la perfusion analizada mediante ecocardiografia miocardica con contraste intracoronario (EMC) y con la funcion ventricular a los 6 meses Metodos Se incluyo en el estudio a 40 pacientes con un primer infarto agudo de miocardio con elevacion del segmento ST, enfermedad de un vaso y arteria relacionada con el infarto abierta. La perfusion se cuantifico por angiografia (mediana quinto dia, rango de 3-7) mediante el blush miocardico en nuestro laboratorio y en un laboratorio central independiente. Se realizo EMC. Se cuantifico la fraccion de eyeccion al sexto mes mediante resonancia magnetica. Resultados Hallamos una correlacion debil (r = 0,38) entre los 2 laboratorios. La concordancia en las medidas de blush fue del 80%, con un indice kappa de 0,43 si se definia como perfusion normal un blush 2-3, y una concordancia del 55% y un indice kappa de 0,1 para un blush 3. Ni la perfusion analizada mediante EMC (r = 0,23; p = 0,2) ni la fraccion de eyeccion al sexto mes por resonancia (r = 0,20; p = 0,3) se correlacionaron con el blush. Conclusiones Tras un infarto en pacientes con flujo TIMI 3 hemos encontrado una variabilidad considerable en las medidas del blush entre un hospital universitario y un laboratorio central independiente, por lo que parece aconsejable realizar la medida de este indice en laboratorios de referencia altamente especializados. La correlacion con la perfusion analizada mediante EMC y con la funcion sistolica fue escasa.

[1]  W. O’Neill,et al.  Myocardial contrast echocardiography is superior to other known modalities for assessing myocardial reperfusion after acute myocardial infarction , 2003, Heart.

[2]  O. Kamp,et al.  Serial evaluation of perfusion defects in patients with a first acute myocardial infarction referred for primary PTCA using intravenous myocardial contrast echocardiography. , 2001, European heart journal.

[3]  Y. Taniyama,et al.  Myocardial perfusion patterns related to thrombolysis in myocardial infarction perfusion grades after coronary angioplasty in patients with acute anterior wall myocardial infarction. , 1996, Circulation.

[4]  Nicole Heussen,et al.  Prediction of clinical outcome after mechanical revascularization in acute myocardial infarction by markers of myocardial reperfusion. , 2003, Journal of the American College of Cardiology.

[5]  S. Kaul,et al.  Coronary reserve abnormalities in the infarcted myocardium. Assessment of myocardial viability immediately versus late after reflow by contrast echocardiography. , 1996, Circulation.

[6]  B. Brodie,et al.  Importance of infarct-related artery patency for recovery of left ventricular function and late survival after primary angioplasty for acute myocardial infarction. , 1996, Journal of the American College of Cardiology.

[7]  H. Suryapranata,et al.  Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction: myocardial blush grade. Zwolle Myocardial Infarction Study Group. , 1998, Circulation.

[8]  J. Núñez,et al.  Significance of exercise-induced ST segment elevation in Q leads in patients with a recent myocardial infarction and an open infarct-related artery Analysis with angiography, intracoronary myocardial contrast echocardiography and cardiac magnetic resonance. , 2005, International journal of cardiology.

[9]  J. J. Griffin,et al.  Frequency, correlates, and clinical implications of myocardial perfusion after primary angioplasty and stenting, with and without glycoprotein IIb/IIIa inhibition, in acute myocardial infarction. , 2004, Journal of the American College of Cardiology.

[10]  S. Kaul,et al.  Coronary angiography cannot be used to assess myocardial perfusion in patients undergoing reperfusion for acute myocardial infarction , 2001, Heart.

[11]  J. Núñez,et al.  Usefulness of a comprehensive cardiovascular magnetic resonance imaging assessment for predicting recovery of left ventricular wall motion in the setting of myocardial stunning. , 2005, Journal of the American College of Cardiology.

[12]  Gusto Angiographic Investigators The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction. , 1993, The New England journal of medicine.

[13]  M. Cerqueira,et al.  Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. , 2002, Circulation.

[14]  P. Steg,et al.  Acute assessment of microvascular perfusion patterns by myocardial contrast echocardiography during myocardial infarction: relation to timing and extent of functional recovery , 1999, Heart.

[15]  D. Saura,et al.  Utility of the fractional flow reserve in the evaluation of angiographically moderate in-stent restenosis. , 2004, European heart journal.

[16]  V. Bodí,et al.  Usefulness of quantitative intravenous myocardial contrast echocardiography to analyze microvasculature perfusion in patients with a recent myocardial infarction and an open infarct-related artery: comparison with intracoronary myocardial contrast echocardiography. , 2005, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[17]  Felix Zijlstra,et al.  Angiographic Assessment of Reperfusion in Acute Myocardial Infarction by Myocardial Blush Grade , 2003, Circulation.

[18]  G. Nicolosi,et al.  Interobserver and echo-angio variability of two-dimensional colour Doppler evaluation of aortic and mitral regurgitation. , 1989, European heart journal.

[19]  George Dangas,et al.  Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. , 2002, Journal of the American College of Cardiology.

[20]  R. Califf,et al.  Support for the open-artery hypothesis in survivors of acute myocardial infarction: analysis of 11,228 patients treated with thrombolytic therapy. , 1999, The American journal of cardiology.

[21]  J. Millet,et al.  Estudio de perfusión en pacientes postinfarto mediante ecografía miocárdica con inyección de contraste intracoronario. Implicaciones y relación con la angiografía y la resonancia magnética , 2004 .

[22]  B. Sievers,et al.  Single and biplane TrueFISP cardiovascular magnetic resonance for rapid evaluation of left ventricular volumes and ejection fraction. , 2004, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.