pH‐Switchable Bioelectrocatalysis Based on Weak Polyelectrolyte Multilayers

Weak polyelectrolytes poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA) were assembled into {PAH/PAA}n layer-by-layer films on electrodes. The cyclic voltammetry (CV) response of ferrocenecarboxylic acid (Fc(COOH)) at {PAH/PAA}5 film electrodes assembled under the specific condition showed pH-sensitive “on-off” switching property. This property was further used to control the electrocatalytic oxidation of glucose by glucose oxidase (GOD) with Fc(COOH) as the electron transfer mediator, so that the pH-switchable bioelectrocatalysis could be realized. The mechanism of pH-sensitive behavior of the system was explored and believed to originate from the pH-dependent structure change of the films.

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