Combined effect of gender and caloric restriction on liver proteomic expression profile.

We analyzed the combined effect of gender and CR on protein expression profile in liver. We identified 27 differentially expressed proteins involved in several cellular functions such as substrate metabolism, antioxidant systems, stress response, iron homeostasis and cardiovascular protection. This study reveals new cellular pathways liable to be similarly regulated in females and calorie restricted rats and which could be related with the greater longevity in these animals.

[1]  W. Ward,et al.  Effect of aging and caloric restriction on the mitochondrial proteome. , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

[2]  P. Roca,et al.  Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions. , 2007, American journal of physiology. Cell physiology.

[3]  M. Mattson,et al.  Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. , 2007, Endocrinology.

[4]  R. May.  Gender, immunity and the regulation of longevity. , 2007, BioEssays : news and reviews in molecular, cellular and developmental biology.

[5]  M. Lunder,et al.  The role of gender and sex hormones in ischemic-reperfusion injury in isolated rat hearts. , 2007, European journal of pharmacology.

[6]  S. Goto,et al.  Beneficial Biochemical Outcomes of Late‐Onset Dietary Restriction in Rodents , 2007, Annals of the New York Academy of Sciences.

[7]  R. Acquaviva,et al.  Rutin in rat liver ischemia/reperfusion injury: Effect on DDAH/NOS pathway , 2007, Microsurgery.

[8]  Y. Higami,et al.  Hepatic gene expression profile of lipid metabolism in rats: Impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[9]  S. Klein,et al.  Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones. , 2006, The Journal of clinical endocrinology and metabolism.

[10]  M. Mattson,et al.  Bioenergetics of aging and calorie restriction , 2006, Ageing Research Reviews.

[11]  A. Proenza,et al.  Effects of caloric restriction and gender on rat serum paraoxonase 1 activity. , 2006, The Journal of nutritional biochemistry.

[12]  J. Sastre,et al.  Role of mitochondrial oxidative stress to explain the different longevity between genders. Protective effect of estrogens , 2006, Free radical research.

[13]  K. Ho,et al.  Regulating of growth hormone sensitivity by sex steroids: implications for therapy. , 2006, Frontiers of hormone research.

[14]  J. Bermúdez,et al.  Gender dimorphism in rat liver mitochondrial oxidative metabolism and biogenesis. , 2005, American journal of physiology. Cell physiology.

[15]  J. Sastre,et al.  Why females live longer than males? Importance of the upregulation of longevity‐associated genes by oestrogenic compounds , 2005, FEBS letters.

[16]  G. Biolo,et al.  Moderate caloric restriction, but not physiological hyperleptinemia per se, enhances mitochondrial oxidative capacity in rat liver and skeletal muscle--tissue-specific impact on tissue triglyceride content and AKT activation. , 2005, Endocrinology.

[17]  K. Clément,et al.  Transcriptomics applied to obesity and caloric restriction. , 2005, Biochimie.

[18]  J. Sastre,et al.  17beta-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade. , 2005, Aging cell.

[19]  D. Waxman,et al.  Sexual Dimorphism of Rat Liver Nuclear Proteins , 2004, Molecular & Cellular Proteomics.

[20]  J. Silha,et al.  Sexual dimorphism and regulation of resistin, adiponectin, and leptin expression in the mouse. , 2004, Obesity research.

[21]  J. E. Silva,et al.  Mice with deletion of the mitochondrial glycerol-3-phosphate dehydrogenase gene exhibit a thrifty phenotype: effect of gender. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

[22]  A. Bartke,et al.  Additive regulation of hepatic gene expression by dwarfism and caloric restriction. , 2004, Physiological genomics.

[23]  Karl H. Clodfelter,et al.  Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis. , 2004, Molecular endocrinology.

[24]  S. Kalhan,et al.  Gender differences in the regulation of amino acid metabolism. , 2003, Journal of applied physiology.

[25]  J. Sastre,et al.  Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. , 2003, Free radical biology & medicine.

[26]  N. Martin,et al.  Relative importance of female‐specific and non‐female‐specific effects on variation in iron stores between women , 2003, British journal of haematology.

[27]  Enrique Herrero,et al.  Mitochondrial Hsp60, Resistance to Oxidative Stress, and the Labile Iron Pool Are Closely Connected in Saccharomyces cerevisiae * , 2002, The Journal of Biological Chemistry.

[28]  B. Merry.  Molecular mechanisms linking calorie restriction and longevity. , 2002, The international journal of biochemistry & cell biology.

[29]  W. Voos,et al.  Molecular chaperones as essential mediators of mitochondrial biogenesis. , 2002, Biochimica et biophysica acta.

[30]  D. Ingram,et al.  Effects of Dietary Caloric Restriction and Aging on Thyroid Hormones of Rhesus Monkeys , 2002, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[31]  B. Lunenfeld,et al.  The Aging Male , 2002 .

[32]  Elias S. J. Arnér,et al.  Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. , 2001, Free radical biology & medicine.

[33]  Andrzej Bartke,et al.  Longevity: Extending the lifespan of long-lived mice , 2001, Nature.

[34]  W. Ryder,et al.  The relationship between serum GH and serum IGF-I in acromegaly is gender-specific. , 2001, The Journal of clinical endocrinology and metabolism.

[35]  D. Rosenthal,et al.  Thyroid function and aging: gender-related differences. , 2001, The Journal of endocrinology.

[36]  Y. Higami,et al.  Leptin signaling and aging: insight from caloric restriction , 2001, Mechanisms of Ageing and Development.

[37]  R. Weindruch,et al.  Caloric restriction lowers plasma lipoprotein (a) in male but not female rhesus monkeys , 2001, Experimental Gerontology.

[38]  T. Grune,et al.  Proteolysis, caloric restriction and aging , 2001, Mechanisms of Ageing and Development.

[39]  Richard A. Miller,et al.  Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[40]  S. Yamamoto,et al.  Iron content of rat serum ferritin. , 2001, The Journal of veterinary medical science.

[41]  J. Wilmoth,et al.  Increase of maximum life-span in Sweden, 1861-1999. , 2000, Science.

[42]  R. Cortright,et al.  Sex differences in substrate metabolism and energy homeostasis. , 2000, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[43]  D. Clemmons,et al.  Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. , 2000, Endocrinology.

[44]  M. Wong,et al.  Glutathione S-transferases--a review. , 1999, Current medicinal chemistry.

[45]  N. Wong,et al.  Hormonal regulation of apolipoprotein AI. , 1999, Journal of molecular endocrinology.

[46]  C. Klaassen,et al.  Regulation of sulfotransferase mRNA expression in male and female rats of various ages. , 1998, Chemico-biological interactions.

[47]  K. Hornbrook,et al.  Thiol-Disulfide Exchange Systems in the Liver of Aging Fischer 344 Rats , 1998, Gerontology.

[48]  J. Ordovás,et al.  Impact of gender on the metabolism of apolipoprotein A-I in HDL subclasses LpAI and LpAI:AII in older subjects. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[49]  K. M. Popov,et al.  Gender difference in regulation of branched-chain amino acid catabolism. , 1997, The Biochemical journal.

[50]  H. Langen,et al.  Identification of proteins by matrix-assisted laser desorption ionization-mass spectrometry following in-gel digestion in low-salt, nonvolatile buffer and simplified peptide recovery. , 1997, Analytical biochemistry.

[51]  J. Kopchick,et al.  Deletion of the mouse GH-binding protein (mGHBP) mRNA polyadenylation and splicing sites does not abolish production of mGHBP. , 1997, Journal of molecular endocrinology.

[52]  S. Klein,et al.  Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. , 1996, The Journal of clinical endocrinology and metabolism.

[53]  J. Veldhuis.  Gender differences in secretory activity of the human somatotropic (growth hormone) axis. , 1996, European journal of endocrinology.

[54]  F. Hartl,et al.  Protein folding in the cell: competing models of chaperonin function , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[55]  F. Sacks,et al.  Sex hormones, lipoproteins, and vascular reactivity , 1995, Current opinion in lipidology.

[56]  J. Hayes,et al.  Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1. , 1994, The Journal of biological chemistry.

[57]  R. Kato,et al.  Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyzes activation of N-hydroxy-2-acetylaminofluorene. , 1993, The Journal of biological chemistry.

[58]  G. Schonfeld,et al.  In vivo regulation of low-density lipoprotein receptors by estrogen differs at the post-transcriptional level in rat and mouse. , 1993, European journal of biochemistry.

[59]  P. Srivastava,et al.  Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver. , 1993, The Biochemical journal.

[60]  A. North,et al.  Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography , 1992, Nature.

[61]  M. Noshiro,et al.  delta 4-3-Oxosteroid 5 beta-reductase. Structure and function. , 1991, Biological chemistry Hoppe-Seyler.

[62]  E. Krul,et al.  In vivo regulation of apolipoprotein A-I gene expression by estradiol and testosterone occurs at the translational level in inbred strains of mice. , 1991, Biochemical and biophysical research communications.

[63]  M. Seishima,et al.  Regulation of hepatic apolipoprotein synthesis in the 17 ~ ethinyl estradiol-treated rat , 1991 .

[64]  A. Holmgren,et al.  Thioredoxin and glutaredoxin systems. , 2019, The Journal of biological chemistry.

[65]  R. Mittelstaedt,et al.  Effect of chronic caloric restriction on hepatic enzymes of intermediary metabolism in the male Fischer 344 rat , 1989, Mechanisms of Ageing and Development.

[66]  Richard Weindruch,et al.  The Retardation of Aging and Disease by Dietary Restriction , 1988 .

[67]  N. Wong,et al.  Advances in our understanding of thyroid hormone action at the cellular level. , 1987, Endocrine reviews.

[68]  A. Donda,et al.  Influence of sex and age on T3 receptors and T3 concentration in the pituitary gland of the rat: consequences on TSH secretion. , 1987, Molecular and cellular endocrinology.

[69]  M. Digirolamo,et al.  Energy utilization in food-restricted female rats. , 1986, The Journal of nutrition.

[70]  J. Hill,et al.  Effects of variable caloric restriction on utilization of ingested energy in rats. , 1985, The American journal of physiology.

[71]  J. Jansson,et al.  Sexual dimorphism in the control of growth hormone secretion. , 1985, Endocrine reviews.

[72]  M. Mclaughlin,et al.  The structure and expression of very closely related members of the alpha 2u globulin gene family. , 1982, The Journal of biological chemistry.

[73]  H. Munro,et al.  Adaptive responses of rat tissue isoferritins to iron administration. Changes in subunit synthesis, isoferritin abundance, and capacity for iron storage. , 1981, The Journal of biological chemistry.

[74]  E. Widdowson.  The response of the sexes to nutritional stress , 1976, Proceedings of the Nutrition Society.