Gonadotropin-inhibitory contaminants in partially purified pharmaceutical preparations of human chorionic gonadotropin.

Various commercial preparations of partially purified human chorionic gonadotropin, inactivated by heating, inhibited the uterine growth induced in immature mice with the same active gonadotropins as well as spontaneous uterine growth. The more purified preparations of chorionic gonadotropin failed to produce these effects after inactivation by boiling, suggesting that the inhibitory activity is not generated from gonadotropin by the procedure but may be related to some contaminant similar to the gonadotropin-inhibitory substance previously found in human urine.

[1]  B. Lunenfeld,et al.  Immunology of human chorionic gonadotropin (HCG). , 1967, Vitamins and hormones.

[2]  W. F. Blatt,et al.  Preparation of human chorionic gonadotrophin of high specific activity. , 1966, The Journal of endocrinology.

[3]  W. Futterweit,et al.  A gonadotrophin-inhibiting substance in the urine of normal subjects. , 1962, The Journal of clinical endocrinology and metabolism.

[4]  W. Futterweit,et al.  A gonadotropin-inhibiting substance in the urine of normal young children. , 1961, The Journal of clinical endocrinology and metabolism.

[5]  H. S. Schwartz,et al.  Presence of a gonadotropin-inhibiting factor in urine of young children. , 1960, Metabolism: clinical and experimental.