A variance components/major locus likelihood approximation on quantitative data

The variance components/major locus model encompasses a major locus, a polygenic component, and shared environmental effects. The model attributes familial correlations to polygenic and shared environmental effects when testing for major locus inheritance or accounts for the major locus when estimating variance components.

[1]  S J Hasstedt,et al.  A mixed-model likelihood approximation on large pedigrees. , 1982, Computers and biomedical research, an international journal.

[2]  Morton Ne.  Analysis of family resemblance. I. Introduction. , 1974 .

[3]  N E Morton,et al.  Complex segregation analysis with pointers. , 1981, Human heredity.

[4]  C. Sing,et al.  Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan. V. Variance components estimated from pedigrees , 1979, Annals of human genetics.

[5]  D. Rao,et al.  Search for faster methods of fitting the regressive models to quantitative traits , 1990, Genetic epidemiology.

[6]  Mark H. Skolnick,et al.  Pedigree Analysis of Complex Models , 1980 .

[7]  M. E. Ramirez,et al.  Recessive inheritance of a relative fat pattern. , 1989, American journal of human genetics.

[8]  M. Leppert,et al.  A DNA probe for the LDL receptor gene is tightly linked to hypercholesterolemia in a pedigree with early coronary disease. , 1986, American journal of human genetics.

[9]  R. Elston,et al.  Multifactorial genetic models for quantitative traits in humans. , 1979, Biometrics.

[10]  R. Elston,et al.  A general model for the genetic analysis of pedigree data. , 1971, Human heredity.

[11]  J. Ott,et al.  Maximum likelihood estimation by counting methods under polygenic and mixed models in human pedigrees. , 1979, American journal of human genetics.

[12]  K. Ash,et al.  Evidence that men with familial hypercholesterolemia can avoid early coronary death. An analysis of 77 gene carriers in four Utah pedigrees. , 1986, Journal of the American Medical Association (JAMA).

[13]  N E Morton,et al.  Analysis of family resemblance. 3. Complex segregation of quantitative traits. , 1974, American journal of human genetics.

[14]  C. Cannings,et al.  Probability functions on complex pedigrees , 1978, Advances in Applied Probability.

[15]  J. Westlake,et al.  Estimation of the variance components for dermal ridge count , 1977, Annals of human genetics.

[16]  G. Bonney,et al.  On the statistical determination of major gene mechanisms in continuous human traits: regressive models. , 1984, American journal of medical genetics.

[17]  R. Fisher.  XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance. , 1919, Transactions of the Royal Society of Edinburgh.

[18]  N. Morton,et al.  A defense of path analysis in genetic epidemiology. , 1983, American journal of human genetics.

[19]  N. Morton,et al.  Analysis of family resemblance. II. A linear model for familial correlation. , 1974, American journal of human genetics.

[20]  K. Lange,et al.  Extensions to pedigree analysis III. Variance components by the scoring method , 1976, Annals of human genetics.