Materials-driven fibronectin assembly on nanoscale topography enhances mesenchymal stem cell adhesion, protecting cells from bacterial virulence factors and preventing biofilm formation.

[1]  Denver P. Linklater,et al.  The multi-faceted mechano-bactericidal mechanism of nanostructured surfaces , 2020, Proceedings of the National Academy of Sciences.

[2]  B. Gao,et al.  Bacterial Flagella Loss under Starvation. , 2020, Trends in microbiology.

[3]  Dejun Li,et al.  Study on the osteogenesis of rat mesenchymal stem cells and the long-term antibacterial activity of Staphylococcus epidermidis on the surface of silver-rich TiN/Ag modified titanium alloy. , 2020, Journal of biomedical materials research. Part B, Applied biomaterials.

[4]  M. Salmerón-Sánchez,et al.  Plasma polymerised nanoscale coatings of controlled thickness for efficient solid-phase presentation of growth factors. , 2020, Materials science & engineering. C, Materials for biological applications.

[5]  K. Gall,et al.  Modulating antibiotic release from reservoirs in 3D‐printed orthopedic devices to treat periprosthetic joint infection , 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[6]  S. Shiels,et al.  Revisiting the "race for the surface" in a pre-clinical model of implant infection. , 2020, European cells & materials.

[7]  C. Lorenz,et al.  Minor Chemistry Changes Alter Surface Hydration to Control Fibronectin Adsorption and Assembly into Nanofibrils , 2019, Advanced Theory and Simulations.

[8]  D. B. Sbhatu,et al.  Challenges of intervention, treatment, and antibiotic resistance of biofilm-forming microorganisms , 2019, Heliyon.

[9]  P. Savage,et al.  Arthroplasty infection rates in fractured neck of femur: single vs dual antibiotic cement. , 2019, Annals of the Royal College of Surgeons of England.

[10]  Ali Khademhosseini,et al.  Three-dimensional printing of metals for biomedical applications , 2019, Materials today. Bio.

[11]  D. Mooney,et al.  Sequential modes of crosslinking tune viscoelasticity of cell-instructive hydrogels. , 2019, Biomaterials.

[12]  Hannah Donnelly,et al.  Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects , 2018, Advanced science.

[13]  J. Hubbell,et al.  Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing , 2018, Nature Communications.

[14]  P. May,et al.  Studies of black silicon and black diamond as materials for antibacterial surfaces. , 2018, Biomaterials science.

[15]  Matthew J. Dalby,et al.  Receptor control in mesenchymal stem cell engineering , 2018 .

[16]  J. Reboud,et al.  Molecular clutch drives cell response to surface viscosity , 2018, Proceedings of the National Academy of Sciences.

[17]  H. Kessler,et al.  Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands , 2017, Scientific Reports.

[18]  Damiano Pasini,et al.  Fully porous 3D printed titanium femoral stem to reduce stress‐shielding following total hip arthroplasty , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[19]  T. Webster,et al.  Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[20]  S. Assemi,et al.  Contribution of Nano- to Microscale Roughness to Heterogeneity: Closing the Gap between Unfavorable and Favorable Colloid Attachment Conditions. , 2017, Environmental science & technology.

[21]  A. Sudlow,et al.  Orthopaedic surgical site infection surveillance in NHS England: NATIONAL AUDIT OF CURRENT PRACTICE , 2017, The bone & joint journal.

[22]  B. Su,et al.  Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates , 2016, Scientific Reports.

[23]  Andrés J. García,et al.  Material-driven fibronectin assembly for high-efficiency presentation of growth factors , 2016, Science Advances.

[24]  O. MacDougald,et al.  Reciprocal Control of Osteogenic and Adipogenic Differentiation by ERK/MAP Kinase Phosphorylation of Runx2 and PPARγ Transcription Factors , 2016, Journal of cellular physiology.

[25]  E. A. Cavalcanti-Adam,et al.  Tuning cellular responses to BMP-2 with material surfaces. , 2016, Cytokine & growth factor reviews.

[26]  James C. Weaver,et al.  Hydrogels with tunable stress relaxation regulate stem cell fate and activity , 2015, Nature materials.

[27]  Mikaël M. Martino,et al.  Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing. , 2015, Advances in wound care.

[28]  Geetha Manivasagam,et al.  Bacterial adherence and biofilm formation on medical implants: A review , 2014, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[29]  Enateri V. Alakpa,et al.  Nanotopographical induction of osteogenesis through adhesion, bone morphogenic protein cosignaling, and regulation of microRNAs. , 2014, ACS nano.

[30]  Yu Suk Choi,et al.  Interplay of Matrix Stiffness and Protein Tethering in Stem Cell Differentiation , 2014, Nature materials.

[31]  Andrés J. García,et al.  Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle. , 2014, Biomaterials.

[32]  Nikolaj Gadegaard,et al.  Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate. , 2014, Nature materials.

[33]  Fengyun Gong,et al.  Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone attenuates lipopolysaccharide-induced inflammation by activating the unfolded protein response. , 2014, Biomedical reports.

[34]  Saulius Juodkazis,et al.  Bactericidal activity of black silicon , 2013, Nature Communications.

[35]  K. Hankenson,et al.  Mesenchymal Stem Cells in Bone Regeneration. , 2013, Advances in wound care.

[36]  N. Epstein,et al.  Complications due to the use of BMP/INFUSE in spine surgery: The evidence continues to mount , 2013, Surgical neurology international.

[37]  Nikolaj Gadegaard,et al.  Using nanotopography and metabolomics to identify biochemical effectors of multipotency. , 2012, ACS nano.

[38]  E. Woo.  Recombinant human bone morphogenetic protein-2: adverse events reported to the Manufacturer and User Facility Device Experience database. , 2012, The spine journal : official journal of the North American Spine Society.

[39]  Elena P Ivanova,et al.  Natural bactericidal surfaces: mechanical rupture of Pseudomonas aeruginosa cells by cicada wings. , 2012, Small.

[40]  R. Breitling,et al.  Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction. , 2011, Analytical chemistry.

[41]  Ralph Müller,et al.  Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing , 2011, Science Translational Medicine.

[42]  P. O'shea,et al.  The Interaction of N-Acylhomoserine Lactone Quorum Sensing Signaling Molecules with Biological Membranes: Implications for Inter-Kingdom Signaling , 2010, PloS one.

[43]  Milan Mrksich,et al.  Geometric cues for directing the differentiation of mesenchymal stem cells , 2010, Proceedings of the National Academy of Sciences.

[44]  Tatiana Segura,et al.  Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells , 2010, The Journal of cell biology.

[45]  Andrés J. García,et al.  Bioartificial matrices for therapeutic vascularization , 2009, Proceedings of the National Academy of Sciences.

[46]  Richard O. Hynes,et al.  The Extracellular Matrix: Not Just Pretty Fibrils , 2009, Science.

[47]  David J. Mooney,et al.  Growth Factors, Matrices, and Forces Combine and Control Stem Cells , 2009, Science.

[48]  C. Streuli,et al.  Signal co-operation between integrins and other receptor systems. , 2009, The Biochemical journal.

[49]  K. Ren,et al.  Layer-by-layer films as a biomimetic reservoir for rhBMP-2 delivery: controlled differentiation of myoblasts to osteoblasts. , 2009, Small.

[50]  Francois Malherbe,et al.  Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus Attachment Patterns on Glass Surfaces with Nanoscale Roughness , 2009, Current Microbiology.

[51]  Steven M. Kurtz,et al.  The Epidemiology of Revision Total Knee Arthroplasty in the United States , 2009, Clinical orthopaedics and related research.

[52]  C. Wilkinson,et al.  The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. , 2007, Nature materials.

[53]  Vivian H. Fan,et al.  Tethered Epidermal Growth Factor Provides a Survival Advantage to Mesenchymal Stem Cells , 2007, Stem cells.

[54]  Renny T. Franceschi,et al.  Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development , 2007, The Journal of cell biology.

[55]  Judith M Curran,et al.  The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. , 2006, Biomaterials.

[56]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[57]  Christopher S. Chen,et al.  Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. , 2004, Developmental cell.

[58]  L. Trusolino,et al.  Interactions between growth factor receptors and adhesion molecules: breaking the rules. , 2003, Current opinion in cell biology.

[59]  Kenneth M. Yamada,et al.  Fibronectin at a glance , 2002, Journal of Cell Science.

[60]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[61]  P Zioupos,et al.  Mechanical properties and the hierarchical structure of bone. , 1998, Medical engineering & physics.

[62]  Philip R. Kuhl,et al.  Tethered epidermal growth factor as a paradigm for growth factor–induced stimulation from the solid phase , 1996, Nature Medicine.

[63]  Y. Ito,et al.  Protein-free cell culture on an artificial substrate with covalently immobilized insulin. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[64]  M Drancourt,et al.  Treatment of Pseudomonas aeruginosa-infected orthopedic prostheses with ceftazidime-ciprofloxacin antibiotic combination , 1995, Antimicrobial agents and chemotherapy.

[65]  R. B. Ashman,et al.  Young's modulus of trabecular and cortical bone material: ultrasonic and microtensile measurements. , 1993, Journal of biomechanics.

[66]  W. Bonfield,et al.  Hydroxyapatite reinforced polyethylene--a mechanically compatible implant material for bone replacement. , 1981, Biomaterials.

[67]  L L Hench,et al.  Direct chemical bond of bioactive glass-ceramic materials to bone and muscle. , 1973, Journal of biomedical materials research.

[68]  J. Helms,et al.  Relationship Between Primary/Mechanical and Secondary/Biological Implant Stability. , 2019, The International journal of oral & maxillofacial implants.

[69]  R. Langer,et al.  Radial extracorporeal shock wave therapy (rESWT) induces new bone formation in vivo: results of an animal study in rabbits. , 2013, Ultrasound in medicine & biology.