3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering

Piezoelectricity in native bones has been well recognized as the key factor in bone regeneration. Thus, bio-piezoelectric materials have gained substantial attention in repairing damaged bone by mimicking the tissue’s electrical microenvironment (EM). However, traditional manufacturing strategies still encounter limitations in creating personalized bio-piezoelectric scaffolds, hindering their clinical applications. Three-dimensional (3D)/four-dimensional (4D) printing technology based on the principle of layer-by-layer forming and stacking of discrete materials has demonstrated outstanding advantages in fabricating bio-piezoelectric scaffolds in a more complex-shaped structure. Notably, 4D printing functionality-shifting bio-piezoelectric scaffolds can provide a time-dependent programmable tissue EM in response to external stimuli for bone regeneration. In this review, we first summarize the physicochemical properties of commonly used bio-piezoelectric materials (including polymers, ceramics, and their composites) and representative biological findings for bone regeneration. Then, we discuss the latest research advances in the 3D printing of bio-piezoelectric scaffolds in terms of feedstock selection, printing process, induction strategies, and potential applications. Besides, some related challenges such as feedstock scalability, printing resolution, stress-to-polarization conversion efficiency, and non-invasive induction ability after implantation have been put forward. Finally, we highlight the potential of shape/property/functionality-shifting smart 4D bio-piezoelectric scaffolds in bone tissue engineering (BTE). Taken together, this review emphasizes the appealing utility of 3D/4D printed biological piezoelectric scaffolds as next-generation BTE implants.

[1]  D. Puleo,et al.  Characterization of 3D printed biodegradable piezoelectric scaffolds for bone regeneration , 2023, Clinical and experimental dental research.

[2]  Danling Luo,et al.  Application of Piezoelectric Material and Devices in Bone Regeneration , 2022, Nanomaterials.

[3]  P. Coveney,et al.  Hierarchically structured bioinspired nanocomposites , 2022, Nature Materials.

[4]  C. Vyas,et al.  Hybrid biomanufacturing systems applied in tissue regeneration , 2022, International journal of bioprinting.

[5]  K. Leong,et al.  Multi-material and Multi-dimensional 3D Printing for Biomedical Materials and Devices , 2022, Biomedical Materials & Devices.

[6]  Q. Cai,et al.  A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration. , 2022, Bioactive materials.

[7]  Ping Wu,et al.  Ultrasound-driven in vivo electrical stimulation based on biodegradable piezoelectric nanogenerators for enhancing and monitoring the nerve tissue repair , 2022, Nano Energy.

[8]  P. Sainsot,et al.  Ceria-stabilized zirconia-based composites printed by stereolithography: Impact of the processing method on the ductile behaviour and its transformation features , 2022, Journal of the European Ceramic Society.

[9]  P. Sikder,et al.  3D-Printed Piezoelectric Porous Bioactive Scaffolds and Clinical Ultrasonic Stimulation Can Help in Enhanced Bone Regeneration , 2022, Bioengineering.

[10]  C. Yan,et al.  Multimaterial additive manufacturing manipulator for fabricating magnetoelectric pressure sensors , 2022, Science China Technological Sciences.

[11]  C. Yan,et al.  Laser powder bed fusion of poly-ether-ether-ketone/bioactive glass composites: Processability, mechanical properties, and bioactivity , 2022, Composites Science and Technology.

[12]  Honglian Dai,et al.  Wirelessly Powered Electrical-Stimulation Based on Biodegradable 3D Piezoelectric Scaffolds Promotes the Spinal Cord Injury Repair. , 2022, ACS nano.

[13]  A. V. van Duin,et al.  Increasing density and mechanical performance of binder jetting processing through bimodal particle size distribution , 2022, Materials Science in Additive Manufacturing.

[14]  M. Arjmand,et al.  A review on the recent progress, opportunities, and challenges of 4D printing and bioprinting in regenerative medicine , 2022, Journal of biomaterials science. Polymer edition.

[15]  Jia Liu,et al.  Low temperature hybrid 3D printing of hierarchically porous bone tissue engineering scaffolds with in situ delivery of osteogenic peptide and mesenchymal stem cells , 2022, Biofabrication.

[16]  Geunhyung Kim,et al.  Mechanically and biologically enhanced 3D-printed HA/PLLA/dECM biocomposites for bone tissue engineering. , 2022, International journal of biological macromolecules.

[17]  R. Pugliese,et al.  Artificial Intelligence-Empowered 3D and 4D Printing Technologies toward Smarter Biomedical Materials and Approaches , 2022, Polymers.

[18]  Xiaolian Niu,et al.  Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives , 2022, Bioactive materials.

[19]  N. Vidakis,et al.  Material extrusion 3D printing and friction stir welding: an insight into the weldability of polylactic acid plates based on a full factorial design , 2022, The International Journal of Advanced Manufacturing Technology.

[20]  Ariel A. Calderón,et al.  Design and printing of proprioceptive three-dimensional architected robotic metamaterials , 2022, Science.

[21]  C. Yan,et al.  Comparative evaluation of printability and compression properties of poly-ether-ether-ketone triply periodic minimal surface scaffolds fabricated by laser powder bed fusion , 2022, Additive Manufacturing.

[22]  C. Yan,et al.  Additive manufactured self-powered mechanoelectric sensor as the artificial nucleus pulposus for monitoring tissue rehabilitation after discectomy , 2022, Nano Energy.

[23]  S. Schlögl,et al.  A Review of Multi-Material 3D Printing of Functional Materials via Vat Photopolymerization , 2022, Polymers.

[24]  N. A. Kamel.  Bio-piezoelectricity: fundamentals and applications in tissue engineering and regenerative medicine , 2022, Biophysical Reviews.

[25]  Amit Kumar Sharma,et al.  Engineering a biomimetic bone scaffold that can regulate redox homeostasis and promote osteogenesis to repair large bone defects. , 2022, Biomaterials.

[26]  N. Lecis,et al.  Additive manufacturing of lead-free KNN by binder jetting , 2022, Journal of the European Ceramic Society.

[27]  V. Schulze,et al.  Hybrid material additive manufacturing: interlocking interfaces for fused filament fabrication on laser powder bed fusion substrates , 2022, Virtual and Physical Prototyping.

[28]  Muhammad M. Rahman,et al.  Direct Ink Writing: A 3D Printing Technology for Diverse Materials , 2022, Advanced materials.

[29]  C. Chua,et al.  3D Printed Electronics: Processes, Materials and Future Trends , 2022, Progress in Materials Science.

[30]  C. Yan,et al.  Structure design of arc-shaped auxetic metamaterials with tunable Poisson’s ratio , 2022, Mechanics of Advanced Materials and Structures.

[31]  Di Wang,et al.  Recent progress on additive manufacturing of multi-material structures with laser powder bed fusion , 2022, Virtual and Physical Prototyping.

[32]  M. Schwentenwein,et al.  Vat Photopolymerization Additive Manufacturing of Functionally Graded Materials: A Review , 2022, Journal of Manufacturing and Materials Processing.

[33]  Meysam T. Chorsi,et al.  Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits , 2022, Science Translational Medicine.

[34]  Rubina Ajdary,et al.  Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices , 2021, ACS polymers Au.

[35]  C. Yan,et al.  Three-dimensional printing of gyroid-structured composite bioceramic scaffolds with tuneable degradability. , 2021, Materials science & engineering. C, Materials for biological applications.

[36]  Passakorn Tesavibul,et al.  Effect of particle size on mechanical properties of alumina ceramic processed by photosensitive binder jetting with powder spattering technique , 2021, Journal of the European Ceramic Society.

[37]  Jimin Chen,et al.  3D printing of porous scaffolds BaTiO3 piezoelectric ceramics and regulation of their mechanical and electrical properties , 2021, Ceramics International.

[38]  Qifa Zhou,et al.  Recent progress in 3D printing piezoelectric materials for biomedical applications , 2021, Journal of Physics D: Applied Physics.

[39]  Suraj Kumar Singh,et al.  Printing parameters and materials affecting mechanical properties of FDM-3D printed Parts: Perspective and prospects , 2021, Materials Today: Proceedings.

[40]  Jianping Shi,et al.  The recent development of vat photopolymerization: a review , 2021, Additive Manufacturing.

[41]  Shuning Liu,et al.  Near-zero-shrinkage Al2O3 ceramic foams with coral-like and hollow-sphere structures via selective laser sintering and reaction bonding , 2021, Journal of the European Ceramic Society.

[42]  D. Hutmacher,et al.  Scaffold-Guided Bone Regeneration in large volume tibial segmental defects. , 2021, Bone.

[43]  Xudong Wang,et al.  Bulk Ferroelectric Metamaterial with Enhanced Piezoelectric and Biomimetic Mechanical Properties from Additive Manufacturing. , 2021, ACS nano.

[44]  H. Haick,et al.  Smart Materials Enabled with Artificial Intelligence for Healthcare Wearables , 2021, Advanced Functional Materials.

[45]  Zhixin Chen,et al.  Magnetostrictive-Piezoelectric-Triggered Nanocatalytic Tumor Therapy. , 2021, Nano letters.

[46]  Liqun Zhang,et al.  Electroactive electrospun nanofibers for tissue engineering , 2021 .

[47]  Zhengwei You,et al.  Self-healing polyurethane-elastomer with mechanical tunability for multiple biomedical applications in vivo , 2021, Nature Communications.

[48]  Huiming Wang,et al.  4D Printing of Multi‐Responsive Membrane for Accelerated In Vivo Bone Healing Via Remote Regulation of Stem Cell Fate , 2021, Advanced Functional Materials.

[49]  Robert T. R. Huckstepp,et al.  4D polycarbonates via stereolithography as scaffolds for soft tissue repair , 2021, Nature Communications.

[50]  B. Azimi,et al.  Recent advances of polymer-based piezoelectric composites for biomedical applications. , 2021, Journal of the mechanical behavior of biomedical materials.

[51]  Zhong Lin Wang,et al.  Electroactive Biomaterials and Systems for Cell Fate Determination and Tissue Regeneration: Design and Applications , 2021, Advanced materials.

[52]  Chenyang Zhou,et al.  4D Printing of Lead Zirconate Titanate Piezoelectric Composites Transducer Based on Direct Ink Writing , 2021, Frontiers in Materials.

[53]  K. Zhou,et al.  Construction of Bio‐Piezoelectric Platforms: From Structures and Synthesis to Applications , 2021, Advanced materials.

[54]  K. Wegener,et al.  Direct laser additive manufacturing of high performance oxide ceramics: A state-of-the-art review , 2021 .

[55]  N. Bouropoulos,et al.  Development and Characterization of 3D Printed Multifunctional Bioscaffolds Based on PLA/PCL/HAp/BaTiO3 Composites , 2021, Applied Sciences.

[56]  Ziya Wang,et al.  Vat Photopolymerization 3D Printing of Advanced Soft Sensors and Actuators: From Architecture to Function , 2021, Advanced Materials Technologies.

[57]  N. Lecis,et al.  3D printing of fine alumina powders by binder jetting , 2021 .

[58]  Guo Liu,et al.  Additive manufacturing of structural materials , 2021, Materials Science and Engineering: R: Reports.

[59]  Craig M. Hamel,et al.  Integrating digital light processing with direct ink writing for hybrid 3D printing of functional structures and devices , 2021 .

[60]  Z. Qian,et al.  Review of a new bone tumor therapy strategy based on bifunctional biomaterials , 2021, Bone Research.

[61]  R. Reis,et al.  Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering , 2021, Advanced Functional Materials.

[62]  L. Moroni,et al.  Janus 3D printed dynamic scaffolds for nanovibration-driven bone regeneration , 2021, Nature Communications.

[63]  V. K. Truong,et al.  3D Printable Electrically Conductive Hydrogel Scaffolds for Biomedical Applications: A Review , 2021, Polymers.

[64]  C. Tardivat,et al.  3D printing of dense and porous alkali-activated refractory wastes via Direct Ink Writing (DIW) , 2021 .

[65]  Sung Yun Hann,et al.  4D printing soft robotics for biomedical applications , 2020 .

[66]  Jian Lu,et al.  Development of Bioimplants with 2D, 3D, and 4D Additive Manufacturing Materials , 2020 .

[67]  Ľ. Bača,et al.  Mechanical testing of hydroxyapatite filaments for tissue scaffolds preparation by fused deposition of ceramics , 2020 .

[68]  C. Shuai,et al.  Graphene-assisted barium titanate improves piezoelectric performance of biopolymer scaffold. , 2020, Materials science & engineering. C, Materials for biological applications.

[69]  Q. Cai,et al.  Mimicking the electrophysiological microenvironment of bone tissue using electroactive materials to promote its regeneration. , 2020, Journal of materials chemistry. B.

[70]  Eli J. Curry,et al.  Biodegradable Nanofiber Bone-Tissue Scaffold as Remotely-Controlled and Self-Powering Electrical Stimulator. , 2020, Nano energy.

[71]  S. Tofail,et al.  Piezoelectricity in Sr doped thick films of hydroxyapatite , 2020, IEEE Transactions on Dielectrics and Electrical Insulation.

[72]  C. Shuai,et al.  Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity , 2020, Bioactive materials.

[73]  Yusheng Shi,et al.  Manufacturing Strategies for Solid Electrolyte in Batteries , 2020, Frontiers in Energy Research.

[74]  W. Wang,et al.  Additive manufacturing of hydroxyapatite and its composite materials: A review , 2020 .

[75]  R. Gadow,et al.  Additive manufacturing of bioceramic scaffolds by combination of FDM and slip casting , 2020 .

[76]  A. Elwany,et al.  Metal Binder Jetting Additive Manufacturing: A Literature Review , 2020, Journal of Manufacturing Science and Engineering.

[77]  Eduardo Saiz,et al.  Direct ink writing advances in multi-material structures for a sustainable future , 2020, Journal of Materials Chemistry A.

[78]  D. Khare,et al.  Electrical stimulation and piezoelectric biomaterials for bone tissue engineering applications. , 2020, Biomaterials.

[79]  A. Doostmohammadi,et al.  Novel Porous Barium Titanate/Nano-bioactive Glass Composite with High Piezoelectric Coefficient for Bone Regeneration Applications , 2020, Journal of Materials Engineering and Performance.

[80]  C. Shuai,et al.  A strawberry-like Ag-decorated barium titanate enhances piezoelectric and antibacterial activities of polymer scaffold , 2020 .

[81]  Leyla Esfandiari,et al.  Development of a Piezoelectric PVDF-TrFE Fibrous Scaffold to Guide Cell Adhesion, Proliferation, and Alignment. , 2020, Macromolecular bioscience.

[82]  G. D. Goh,et al.  A review on machine learning in 3D printing: applications, potential, and challenges , 2020, Artificial Intelligence Review.

[83]  S. L. Sing,et al.  Laser powder bed fusion for metal additive manufacturing: perspectives on recent developments , 2020 .

[84]  C. Mota,et al.  A hybrid additive manufacturing platform to create bulk and surface composition gradients on scaffolds for tissue regeneration , 2020, Nature Communications.

[85]  Gerry L. Koons,et al.  Materials design for bone-tissue engineering , 2020, Nature Reviews Materials.

[86]  Howon Lee,et al.  Recent advances in multi-material additive manufacturing: methods and applications , 2020 .

[87]  Yan Zhou,et al.  4D Printing Strain Self‐Sensing and Temperature Self‐Sensing Integrated Sensor–Actuator with Bioinspired Gradient Gaps , 2020, Advanced science.

[88]  Jung-Hyun Kim,et al.  Rapid development of dual porous poly(lactic acid) foam using fused deposition modeling (FDM) 3D printing for medical scaffold application. , 2020, Materials science & engineering. C, Materials for biological applications.

[89]  C. Shuai,et al.  Graphene oxide assists polyvinylidene fluoride scaffold to reconstruct electrical microenvironment of bone tissue , 2020 .

[90]  Daniel Therriault,et al.  Multi‐Material 3D and 4D Printing: A Survey , 2020, Advanced science.

[91]  C. Canal,et al.  Novel synthesis method combining a foaming agent with freeze-drying to obtain hybrid highly macroporous bone scaffolds , 2020 .

[92]  Xiangnan He,et al.  Projection micro stereolithography based 3D printing and its applications , 2020, International Journal of Extreme Manufacturing.

[93]  Hermann Seitz,et al.  3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering , 2020, Materials.

[94]  Yusheng Shi,et al.  Enhanced densification and dielectric properties of CaTiO3-0.3NdAlO3 ceramics fabricated by direct coagulation casting , 2020 .

[95]  Hongzhi Wu,et al.  A Material Combination Concept to Realize 4D Printed Products with Newly Emerging Property/Functionality , 2020, Advanced science.

[96]  Chengtie Wu,et al.  3D printing of Haversian bone–mimicking scaffolds for multicellular delivery in bone regeneration , 2020, Science Advances.

[97]  Jinlong Yang,et al.  3D printing boehmite gel foams into lightweight porous ceramics with hierarchical pore structure , 2020 .

[98]  Sang A Han,et al.  Biomolecular Piezoelectric Materials: From Amino Acids to Living Tissues , 2020, Advanced materials.

[99]  L. Leppik,et al.  Electrical stimulation in bone tissue engineering treatments , 2020, European Journal of Trauma and Emergency Surgery.

[100]  Q. Shubhra,et al.  Piezoelectric Nano‐Biomaterials for Biomedicine and Tissue Regeneration , 2020, Advanced Functional Materials.

[101]  D. Hutmacher,et al.  A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction , 2020, Nature Protocols.

[102]  D. Hutmacher,et al.  A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction , 2020, Nature Protocols.

[103]  Cen Chen,et al.  Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering , 2019, Biomaterials Research.

[104]  Yusheng Shi,et al.  Direct fabrication mechanism of pre-sintered Si3N4 ceramic with ultra-high porosity by laser additive manufacturing , 2019 .

[105]  Yusheng Shi,et al.  TEM analysis and mechanical strengthening mechanism of MnO2 sintering aid in selective laser sintered porous mullites , 2019, Journal of Alloys and Compounds.

[106]  A. Lendlein,et al.  Bioperspectives for shape-memory polymers as shape programmable, active materials. , 2019, Biomacromolecules.

[107]  M. Li,et al.  Mullite ceramic foams with controlled pore structures and low thermal conductivity prepared by SLS using core-shell structured polyamide12/FAHSs composites , 2019, Ceramics International.

[108]  Andrew J E Duncan,et al.  Advanced Polymer Designs for Direct-Ink-Write 3D Printing. , 2019, Chemistry.

[109]  Mohsen Ziaee,et al.  Binder jetting: A review of process, materials, and methods , 2019, Additive Manufacturing.

[110]  Luquan Ren,et al.  Structure-driven biomimetic self-morphing composites fabricated by multi-process 3-D printing , 2019, Composites Part A: Applied Science and Manufacturing.

[111]  Masoud Mozafari,et al.  3D-printed barium strontium titanate-based piezoelectric scaffolds for bone tissue engineering , 2019, Ceramics International.

[112]  Seshadev Sahoo,et al.  A Review on Direct Metal Laser Sintering: Process Features and Microstructure Modeling , 2019, Lasers in Manufacturing and Materials Processing.

[113]  Yusheng Shi,et al.  Porous mullite ceramics with enhanced mechanical properties prepared by SLS using MnO2 and phenolic resin coated double-shell powders , 2019 .

[114]  Howon Lee,et al.  4D printing reconfigurable, deployable and mechanically tunable metamaterials , 2019, Materials Horizons.

[115]  Yusheng Shi,et al.  Lightweight mullite ceramics with controlled porosity and enhanced properties prepared by SLS using mechanical mixed FAHSs/polyamide12 composites , 2019, Ceramics International.

[116]  Chee Kai Chua,et al.  Layer-by-layer ultraviolet assisted extrusion-based (UAE) bioprinting of hydrogel constructs with high aspect ratio for soft tissue engineering applications , 2019, PloS one.

[117]  Mahdi Bodaghi,et al.  4D Printing Self-Morphing Structures , 2019, Materials.

[118]  M. Hurtig,et al.  Beyond Cartilage Repair: The Role of the Osteochondral Unit in Joint Health and Disease , 2019, Tissue engineering. Part B, Reviews.

[119]  Li Yang,et al.  3D printing of ceramics: A review , 2019, Journal of the European Ceramic Society.

[120]  M. Li,et al.  Enhancement mechanism of mechanical performance of highly porous mullite ceramics with bimodal pore structures prepared by selective laser sintering , 2019, Journal of Alloys and Compounds.

[121]  A. Sułowska,et al.  Medical-Grade PCL Based Polyurethane System for FDM 3D Printing—Characterization and Fabrication , 2019, Materials.

[122]  Maxim Shusteff,et al.  Volumetric additive manufacturing via tomographic reconstruction , 2019, Science.

[123]  Shashank Priya,et al.  Three-dimensional printing of piezoelectric materials with designed anisotropy and directional response , 2019, Nature Materials.

[124]  Martin L. Dunn,et al.  Advances in 4D Printing: Materials and Applications , 2018, Advanced Functional Materials.

[125]  R. Liang,et al.  4D Printing based piezoelectric composite for medical applications , 2018, Journal of Polymer Science Part B: Polymer Physics.

[126]  Arvin Bagheri Saed,et al.  Improving mechanical properties of continuous fiber-reinforced thermoplastic composites produced by FDM 3D printer , 2018, Journal of Reinforced Plastics and Composites.

[127]  M. Li,et al.  High-porosity mullite ceramic foams prepared by selective laser sintering using fly ash hollow spheres as raw materials , 2018, Journal of the European Ceramic Society.

[128]  Jinwoo Lee,et al.  Mechanical Analysis of Ceramic/Polymer Composite with Mesh-Type Lightweight Design Using Binder-Jet 3D Printing , 2018, Materials.

[129]  Jianguo Zhu,et al.  Recent development in lead-free perovskite piezoelectric bulk materials , 2018, Progress in Materials Science.

[130]  Jian Lu,et al.  Origami and 4D printing of elastomer-derived ceramic structures , 2018, Science Advances.

[131]  Yusheng Shi,et al.  Effect of K2SO4 additions on properties of porous fibrous alumina ceramics prepared by DCC and lost‐mold method , 2018 .

[132]  S. Cartmell,et al.  Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair. , 2018, Acta biomaterialia.

[133]  Junqi Chen,et al.  A built-in electric field with nanoscale distinction for cell behavior regulation. , 2018, Journal of materials chemistry. B.

[134]  Jaicy Jacob,et al.  Piezoelectric smart biomaterials for bone and cartilage tissue engineering , 2018, Inflammation and regeneration.

[135]  Yusheng Shi,et al.  High-performance ceramic parts with complex shape prepared by selective laser sintering: a review , 2018 .

[136]  Lakmal Seneviratne,et al.  Fused Deposition Modeling for Unmanned Aerial Vehicles (UAVs): A Review , 2018 .

[137]  Clarisse Ribeiro,et al.  In-vivo demonstration of the suitability of piezoelectric stimuli for bone reparation , 2017 .

[138]  Wenmiao Shu,et al.  3D bioactive composite scaffolds for bone tissue engineering , 2017, Bioactive materials.

[139]  Yusheng Shi,et al.  Fabrication of porous fibrous alumina ceramics by direct coagulation casting combined with 3D printing , 2017 .

[140]  Xuliang Deng,et al.  Built‐In Electric Fields Dramatically Induce Enhancement of Osseointegration , 2017 .

[141]  M. Surmeneva,et al.  A comparison study between electrospun polycaprolactone and piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds for bone tissue engineering. , 2017, Colloids and surfaces. B, Biointerfaces.

[142]  Alessandro Fortunato,et al.  Effect of Selective Laser Melting (SLM) process parameters on microstructure and mechanical properties of 316L austenitic stainless steel , 2017 .

[143]  W. Qi,et al.  Preparation of PA11/BaTiO3 nanocomposite powders with improved processability, dielectric and piezoelectric properties for use in selective laser sintering , 2017 .

[144]  Yusheng Shi,et al.  Rapid and uniform in-situ solidification of alumina suspension via a non-contamination DCC-HVCI method using MgO sintering additive as coagulating agent , 2017 .

[145]  Alexander K. Nguyen,et al.  Two-photon polymerization for biological applications , 2017 .

[146]  V. Mattoli,et al.  Ultrasound-activated piezoelectric P(VDF-TrFE)/boron nitride nanotube composite films promote differentiation of human SaOS-2 osteoblast-like cells. , 2017, Nanomedicine : nanotechnology, biology, and medicine.

[147]  R. Guo,et al.  Polyvinylidene fluoride/hydroxyapatite/β-tricalcium phosphate multifunctional biocomposite: Potentialities for bone tissue engineering , 2017 .

[148]  Yusheng Shi,et al.  Rapid in-situ solidification of SiO2 suspension by direct coagulation casting via controlled release of high valence counter ions from calcium iodate and pH shift , 2017 .

[149]  Ryan Wicker,et al.  Multiprocess 3D printing for increasing component functionality , 2016, Science.

[150]  Yan Liu,et al.  Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering. , 2016, Small.

[151]  Wei Zhu,et al.  4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate , 2016, Scientific Reports.

[152]  A. Todoroki,et al.  Three-dimensional printing of continuous-fiber composites by in-nozzle impregnation , 2016, Scientific Reports.

[153]  Barbara Mazzolai,et al.  Two-Photon Lithography of 3D Nanocomposite Piezoelectric Scaffolds for Cell Stimulation. , 2015, ACS applied materials & interfaces.

[154]  Liang Hao,et al.  Ti-6Al-4V triply periodic minimal surface structures for bone implants fabricated via selective laser melting. , 2015, Journal of the mechanical behavior of biomedical materials.

[155]  Lin Yang,et al.  Flexible High‐Energy Polymer‐Electrolyte‐Based Rechargeable Zinc–Air Batteries , 2015, Advanced materials.

[156]  Michael Jaffe,et al.  Piezoelectric materials for tissue regeneration: A review. , 2015, Acta biomaterialia.

[157]  P. Cerri,et al.  Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells , 2015, BioMed research international.

[158]  Ryan B. Wicker,et al.  Fabrication of barium titanate by binder jetting additive manufacturing technology , 2015 .

[159]  Konrad Wegener,et al.  Polymer Powders for Selective Laser Sintering (SLS) , 2015 .

[160]  S. Lang,et al.  Piezoelectricity in Poled Hydroxyapatite Ceramics , 2014 .

[161]  J. Allen,et al.  Biocompatible evaluation of barium titanate foamed ceramic structures for orthopedic applications. , 2014, Journal of biomedical materials research. Part A.

[162]  Hyoun‐Ee Kim,et al.  Highly porous gelatin–silica hybrid scaffolds with textured surfaces using new direct foaming/freezing technique , 2014 .

[163]  S. Evoy,et al.  A review of piezoelectric polymers as functional materials for electromechanical transducers , 2014 .

[164]  Qi Ge,et al.  Active materials by four-dimension printing , 2013 .

[165]  Francisco M. Gama,et al.  Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering , 2013 .

[166]  James J. Yoo,et al.  Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications , 2012, Biofabrication.

[167]  D. Cho,et al.  Bioprinting of a mechanically enhanced three-dimensional dual cell-laden construct for osteochondral tissue engineering using a multi-head tissue/organ building system , 2012 .

[168]  W. Tuan,et al.  Cytotoxicity and degradation behavior of potassium sodium niobate piezoelectric ceramics , 2012 .

[169]  J. Kowalska,et al.  Infrared Spectroscopy in Molecular Study of the Piezoelectric Effect in Pig's Shin Bone , 2012 .

[170]  Rainer Telle,et al.  Direct inkjet printing of Si3N4: Characterization of ink, green bodies and microstructure , 2008 .

[171]  Andreas Greiner,et al.  Electrospinning approaches toward scaffold engineering--a brief overview. , 2006, Artificial organs.

[172]  M. Shamos,et al.  Piezoelectric Effect in Bone , 1963, Nature.

[173]  J. Valasek.  Piezo-Electric and Allied Phenomena in Rochelle Salt , 1921 .

[174]  C. Bao,et al.  3D Structural Electronics Via Multi‐Directional Robot 3D Printing , 2023 .

[175]  Shuning Liu,et al.  Ultra-lightweight ceramic scaffolds with simultaneous improvement of pore interconnectivity and mechanical strength , 2023, Journal of Materials Science & Technology.

[176]  C. Shuai,et al.  Functionalized BaTiO3 enhances piezoelectric effect towards cell response of bone scaffold. , 2019, Colloids and surfaces. B, Biointerfaces.

[177]  Z. Fereshteh.  Freeze-drying technologies for 3D scaffold engineering , 2018 .

[178]  Luca Iuliano,et al.  A literature review of powder-based electron beam melting focusing on numerical simulations , 2018 .

[179]  Bahattin Koc,et al.  Hierarchical and spatial modeling and bio-additive manufacturing of multi-material constructs , 2017 .

[180]  M. R. Sankar,et al.  State of Art on Solvent Casting Particulate Leaching Method for Orthopedic ScaffoldsFabrication , 2017 .

[181]  S. Vargas,et al.  Piezoelectric properties of synthetic hydroxyapatite-based organic-inorganic hydrated materials , 2016 .

[182]  Skylar Tibbits,et al.  4D Printing: Multi‐Material Shape Change , 2014 .

[183]  Wilford W. Spradlin,et al.  The Emergence of I , 1984 .

[184]  A F von Recum,et al.  Piezoelectric ceramic implants: in vivo results. , 1981, Journal of biomedical materials research.

[185]  Of Additively Manufactured , 2022 .