Some Properties of Ciliate Bio-operations

The process of gene unscrambling in ciliates (a type of unicellular protozoa), which accomplishes the difficult task of re-arranging gene segments in the correct order and deleting non-coding sequences from an "encrypted" version of a DNA strand, has been modeled and studied so far from the point of view of the computational power of the DNA bio-operations involved. Here we concentrate on a different aspect of the process, by considering only the linear version of the bio-operations, that do not involve thus any circular strands, and by studying the resulting formal operations from a purely language theoretic point of view. We namely investigate closure operations of language families under the mentioned bio-operations and study language equations involving them. Among the problems addressed, we study the decidability of existence of solutions to equations of the form L ◊ Y = R, X ◊ L = R where L and R are given languages, X and Y are unknowns, and ◊ signifies one of the defined bio-operations.

[1]  Victor Mitrana,et al.  Operations and language generating devices suggested by the genome evolution , 2002, Theor. Comput. Sci..

[2]  L F Landweber,et al.  The evolution of cellular computing: nature's solution to a computational problem. , 1999, Bio Systems.

[3]  Andrzej Ehrenfeucht,et al.  Molecular operations for DNA processing in hypotrichous ciliates , 2001 .

[4]  Jean Berstel,et al.  Context-Free Languages and Pushdown Automata , 1997, Handbook of Formal Languages.

[5]  Andrzej Ehrenfeucht,et al.  Computational Aspects of Gene (Un)Scrambling in Ciliates , 2002 .

[6]  D M Prescott,et al.  Cutting, splicing, reordering, and elimination of DNA sequences in hypotrichous ciliates , 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

[7]  D M Prescott,et al.  The unusual organization and processing of genomic DNA in hypotrichous ciliates. , 1992, Trends in genetics : TIG.

[8]  Seymour Ginsburg,et al.  Algebraic and Automata Theoretic Properties of Formal Languages , 1975 .

[9]  Lila Kari,et al.  Contextual Insertions/Deletions and Computability , 1996, Inf. Comput..

[10]  Peter C. Chapin Formal languages I , 1973, CSC '73.

[11]  David M. Prescott,et al.  Genome gymnastics: unique modes of dna evolution and processing in ciliates , 2000, Nature Reviews Genetics.

[12]  Lila Kari,et al.  Insertion and Deletion of Words: Determinism and Reversibility , 1992, MFCS.

[13]  Lila Kari,et al.  On Language Equations with Invertible Operations , 1994, Theor. Comput. Sci..

[14]  Ion Petre,et al.  Patterns of Micronuclear Genes in ciliates , 2001, DNA.