A computational tool to simulate correlated activity in neural circuits

A new computational approach to study correlated neural activity is presented. Simulating Elementary Neural NEtworks for Correlation Analysis (SENNECA) is a specific-purpose simulator oriented to small circuits of realistic neurons. The model neuron that it implements can reproduce a wide scope of integrate-and-fire models by simply adjusting the parameter set. Three different distributions of SENNECA are available: an easy-to-use web-based version, a Matlab (Windows and Linux) script, and a C++ class library for low-level coding. The main features of the simulator are explained, and several examples of neural activity analysis are given to illustrate the potential of this new tool.

[1]  Stephane A. Roy,et al.  Coincidence Detection or Temporal Integration? What the Neurons in Somatosensory Cortex Are Doing , 2001, The Journal of Neuroscience.

[2]  Carlos D. Brody,et al.  Correlations Without Synchrony , 1999, Neural Computation.

[3]  G. P. Moore,et al.  Neuronal spike trains and stochastic point processes. I. The single spike train. , 1967, Biophysical journal.

[4]  Ad Aertsen,et al.  Dynamics of functional coupling in the cerebral cortex , 1994 .

[5]  Marc-Oliver Gewaltig,et al.  NEST: An Environment for Neural Systems Simulations , 2003 .

[6]  Stefan Rotter,et al.  State space analysis of synchronous spiking in cortical neural networks , 2001, Neurocomputing.

[7]  R C Reid,et al.  Divergence and reconvergence: multielectrode analysis of feedforward connections in the visual system. , 2001, Progress in brain research.

[8]  P. Kirkwood On the use and interpretation of cross-correlation measurements in the mammalian central nervous system , 1979, Journal of Neuroscience Methods.

[9]  Lee M. Miller,et al.  Functional Convergence of Response Properties in the Auditory Thalamocortical System , 2001, Neuron.

[10]  G. P. Moore,et al.  Neuronal spike trains and stochastic point processes. II. Simultaneous spike trains. , 1967, Biophysical journal.

[11]  M K Habib,et al.  Dynamics of neuronal firing correlation: modulation of "effective connectivity". , 1989, Journal of neurophysiology.

[12]  H. Swadlow,et al.  Receptive-field construction in cortical inhibitory interneurons , 2002, Nature Neuroscience.

[13]  John P. Miller,et al.  NeMoSys: A Neural Modeling System , 1993, MASCOTS.

[14]  R. Stein Some models of neuronal variability. , 1967, Biophysical journal.

[15]  Randy M Bruno,et al.  Feedforward Mechanisms of Excitatory and Inhibitory Cortical Receptive Fields , 2002, The Journal of Neuroscience.

[16]  A. Aertsen,et al.  Evaluation of neuronal connectivity: Sensitivity of cross-correlation , 1985, Brain Research.

[17]  Nicholas T. Carnevale,et al.  The NEURON Simulation Environment , 1997, Neural Computation.

[18]  James M. Bower,et al.  The Book of GENESIS , 1994, Springer New York.

[19]  Stefan Rotter,et al.  Exact digital simulation of time-invariant linear systems with applications to neuronal modeling , 1999, Biological Cybernetics.

[20]  Michael Erb,et al.  Coherent Dynamics in the Frontal Cortex of the Behaving Monkey , 1996 .

[21]  A. Zador Impact of synaptic unreliability on the information transmitted by spiking neurons. , 1998, Journal of neurophysiology.

[22]  James J. Watrous Mimicking the Electrical Activity of the Heart Using SNNAP (Simulator for Neural Networks and Action Potentials) , 2005 .

[23]  R. Reid,et al.  Rules of Connectivity between Geniculate Cells and Simple Cells in Cat Primary Visual Cortex , 2001, The Journal of Neuroscience.

[24]  Michael A. Arbib,et al.  The Neural Simulation Language: A System for Brain Modeling , 2002 .

[25]  Ad Aertsen,et al.  Coding and Computation in the Cortex: Single-Neuron Activity and Cooperative Phenomena , 1992 .

[26]  A. Aertsen,et al.  Dynamics of neuronal interactions in monkey cortex in relation to behavioural events , 1995, Nature.

[27]  G. P. Moore,et al.  Statistical analysis and functional interpretation of neuronal spike data. , 1966, Annual review of physiology.