Long-term amelioration of bilirubin glucuronidation defect in Gunn rats by transplanting genetically modified immortalized autologous hepatocytes.

[1]  S. Strom,et al.  Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. , 1998, The New England journal of medicine.

[2]  P. Bosma,et al.  Long-term reduction of serum bilirubin levels in Gunn rats by retroviral gene transfer in vivo. , 1998, Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[3]  C. Guha,et al.  Massive repopulation of rat liver by transplantation of hepatocytes into specific lobes of the liver and ligation of portal vein branches to other lobes. , 1997, Transplantation.

[4]  P. Bosma,et al.  Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation. , 1997, Human gene therapy.

[5]  P. Leboulch,et al.  Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[6]  G. Michalopoulos,et al.  Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium , 1996, The Journal of cell biology.

[7]  N. Fausto,et al.  Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation , 1995, Hepatology.

[8]  S. Gupta,et al.  Integration of transplanted hepatocytes into host liver plates demonstrated with dipeptidyl peptidase IV-deficient rats. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[9]  U. Deuschle,et al.  Tetracycline-reversible silencing of eukaryotic promoters , 1995, Molecular and cellular biology.

[10]  M. Schilsky,et al.  Conditional immortalization of gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin‐UDP‐glucuronosyltransferase gene transfer , 1995, Hepatology.

[11]  P. Bosma,et al.  Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. , 1994, The Journal of biological chemistry.

[12]  James M. Wilson,et al.  Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia , 1994, Nature Genetics.

[13]  E. Yellin,et al.  Studies on the safety of intrasplenic hepatocyte transplantation: relevance to ex vivo gene therapy and liver repopulation in acute hepatic failure. , 1993, Human gene therapy.

[14]  R. Blaese,et al.  Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[15]  J. Wilson,et al.  Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. , 1991, Science.

[16]  R. Burk,et al.  Permanent engraftment and function of hepatocytes delivered to the liver: Implications for gene therapy and Liver Repopulation , 1991, Hepatology.

[17]  F D Ledley,et al.  Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[18]  R. Evans,et al.  Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene. , 1990, Human gene therapy.

[19]  P. Sharp,et al.  Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature , 1989, Molecular and cellular biology.

[20]  C. Petit,et al.  Immortalization of rodent embryo fibroblasts by SV40 is maintained by the A gene. , 1983, Virology.

[21]  N. Chowdhury,et al.  Bilirubin Mono‐ and diglucuronide formation by human liver In vitro: Assay by high‐pressure liquid chromatography , 1981, Hepatology.

[22]  D. Baltimore,et al.  Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase , 1981, Journal of virology.