Anetodermia primaria y anticuerpos antifosfolípidos Primary anetoderma and antiphospholipid antibodies

Primary anetoderma is a rare idiopathic disorder of the skin, characterized by circumscribed areas of slack skin, and loss of elastic fibers upon histopathologic examination. It is occasionally observed in patients with lupus erythematosus or other autoimmune diseases, but has been most consistently associated with antiphospholipid antibodies. We report two cases of primary anetoderma, both with presence of anticardiolipin and anti2glicoprotein I antibodies, and one of them with lupus anticoagulant as well. None of the patients fulfill criteria either for systemic lupus erythematosus or antiphospholipid syndrome. After reviewing the literature, we subscribe to a systematic screening for antiphospholipid antibodies to be performed in each patient with primary anetoderma (Dermatol Argent 2008;14(5): 372-378

[1]  E. M. de Souza,et al.  Anetoderma associated with primary antiphospholipid syndrome. , 2007, Journal of American Academy of Dermatology.

[2]  A. Utani,et al.  Coexistence of disseminated primary anetoderma and generalized granuloma annulare‐like papules , 2007, The Journal of dermatology.

[3]  Y. Shoenfeld,et al.  International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) , 2006, Journal of thrombosis and haemostasis : JTH.

[4]  L. Sammaritano.  Antiphospholipid syndrome: review. , 2005, Southern medical journal.

[5]  J. Sabio,et al.  Anetoderma associated with systemic lupus erythematosus and antiphospholipid antibodies. , 2004, Lupus.

[6]  Y. Molad,et al.  Primary anetoderma: a cutaneous sign of antiphospholipid antibodies , 2003, Lupus.

[7]  A. España,et al.  Systemic lupus erythematosus‐associated anetoderma and anti‐phospholipid antibodies , 2003, Clinical and experimental dermatology.

[8]  G. Godeau,et al.  Anetoderma: An Altered Balance Between Metalloproteinases and Tissue Inhibitors of Metalloproteinases , 2002, The American Journal of dermatopathology.

[9]  J. Romaní,et al.  Anetoderma associated with antiphospholipid antibodies: case report and review of the literature , 2001, Journal of the European Academy of Dermatology and Venereology : JEADV.

[10]  D. Alarcón-Segovia,et al.  Anetoderma in systemic lupus erythematosus: relationship to antiphospholipid antibodies , 2000, Lupus.

[11]  W. Hornebeck,et al.  Increased expression of gelatinases A and B by skin explants from patients with anetoderma , 1997, The British journal of dermatology.

[12]  M. Pittelkow,et al.  Antiphospholipid syndrome and the skin. , 1997, Journal of the American Academy of Dermatology.

[13]  P. Berbis,et al.  [Anetoderma during antiphospholipid syndrome. 3 cases]. , 1996, Annales de dermatologie et de venereologie.

[14]  D. Woodrow,et al.  Anetoderma of Jadassohn-Pellizzari. , 1995, Journal of the Royal Society of Medicine.

[15]  H. Skelton,et al.  INCREASED ANTICARDIOLIPIN ANTIBODIES ASSOCIATED WITH THE DEVELOPMENT OF ANETODERMA IN HIV‐1 DISEASE , 1995, International journal of dermatology.

[16]  E. Stephansson,et al.  Antiphospholipid antibodies and anetoderma: are they associated? , 1995, Dermatology.

[17]  P. Disdier,et al.  Primary anetoderma associated with the antiphospholipid syndrome. , 1994, Journal of the American Academy of Dermatology.

[18]  E. Hodak,et al.  Immunologic abnormalities associated with primary anetoderma. , 1992, Archives of dermatology.

[19]  E. Hodak,et al.  Primary anetoderma associated with a wide spectrum of autoimmune abnormalities. , 1991, Journal of the American Academy of Dermatology.

[20]  O. Vaarala,et al.  Lupus anticoagulant and the skin. A longterm follow-up study of SLE patients with special reference to histopathological findings. , 1991, Acta dermato-venereologica.

[21]  R. Schroh,et al.  Anetodermia y lupus eritematoso: estudio de dos casos , 1987 .

[22]  R. Winkelmann,et al.  Histopathologic findings in anetoderma. , 1984, Archives of dermatology.

[23]  B. Moore,et al.  Anetoderma. Clinical findings, associations, and long-term follow-up evaluations. , 1984, Archives of dermatology.

[24]  S. Kossard,et al.  Inflammatory macular atrophy: immunofluorescent and ultrastructural findings. , 1979, Journal of the American Academy of Dermatology.