论文信息 - Safety and efficacy of loperamide.

Safety and efficacy of loperamide.

Loperamide is a safe and effective antidiarrheal for the treatment of acute diarrhea. Efficacy data suggest that loperamide is more effective than the prescription drug diphenoxylate and an over-the-counter bismuth subsalicylate preparation. Loperamide is a safe drug, with few adverse reactions reported worldwide. It also lacks significant abuse potential. Loperamide may prove to be the antidiarrheal agent of choice when compared with currently available nonprescription treatments for acute diarrhea.

C. Ericsson | P C Johnson | C D Ericsson | P. Johnson

[1] C. Niemegeers,et al. Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs. , 1979, The Journal of pharmacology and experimental therapeutics.

[2] H. Dupont,et al. Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers' diarrhea. , 1986, JAMA.

[3] L. Terenius. Comparison between narcotic "receptors" in the guinea-pig ileum and the rat brain. , 2009, Acta pharmacologica et toxicologica.

[4] W. Amery,et al. A multicentre double-blind study in acute diarrhoea comparing loperamide (R 18553) with two common antidiarrhoeal agents and a placebo. , 1975, Current therapeutic research, clinical and experimental.

[5] V. Schuermans,et al. Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 8: Clinical investigation. Use of a flexible dosage schedule in a double-blind comparison of loperamide with diphenoxylate in 614 patients suffering from acute diarrhea. , 1974, Arzneimittel-Forschung.

[6] J. W. Brown. Toxic megacolon associated with loperamide therapy. , 1979, JAMA.

[7] J H Jaffe,et al. Abuse potential of loperamide , 1980, Clinical pharmacology and therapeutics.