Application of the SAAM modeling program to minimal model analysis of intravenous glucose tolerance test data.

The minimal model approach to analysis of intravenous glucose tolerance tests (IVGTT) yields estimates of parameters representing insulin sensitivity, glucose-mediated glucose disposal and pancreatic responsiveness. The precision of these estimates can deteriorate if the glucose and insulin data lack well-defined structure or freedom from data noise (random error). The precision of parameter estimates can be enhanced if data sets from two or more IVGTTs, obtained under different experimental conditions in the same subject, are analysed together in one data file. Following initial fitting using CONSAM, the conversational version of the modeling program SAAM, those parameters whose estimates remain at the same value under the different experimental conditions are constrained. This effectively reduces the number of adjustable parameters, and their estimates can then be fine-tuned with enhanced precision using the batch version of SAAM.

[1]  C Cobelli,et al.  Quantitative Estimation of Beta Cell Sensitivity to Glucose in the Intact Organism: A Minimal Model of Insulin Kinetics in the Dog , 1980, Diabetes.

[2]  R. DeFronzo,et al.  Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.

[3]  J D Best,et al.  Glucose Disposal is Not Proportional to Plasma Glucose Level in Man , 1981, Diabetes.

[4]  R. Bergman,et al.  Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. , 1981, The Journal of clinical investigation.

[5]  R N Bergman,et al.  Assessment of insulin sensitivity in vivo. , 1985, Endocrine reviews.

[6]  R N Bergman,et al.  The Insulin Sensitivity Index in Nondiabetic Man: Correlation Between Clamp-derived and IVGTT-derived Values , 1986, Diabetes.

[7]  Ra De Fronzo.  Glucose clamp technique : A method for quantifying insulin secretion and resistance , 1979 .

[8]  Y. Z. Ider,et al.  Quantitative estimation of insulin sensitivity. , 1979, The American journal of physiology.

[9]  R N Bergman,et al.  Importance of Glucose Per Se to Intravenous Glucose Tolerance: Comparison of the Minimal-Model Prediction with Direct Measurements , 1985, Diabetes.

[10]  R C Boston,et al.  Alternative method for minimal model analysis of intravenous glucose tolerance data. , 1989, The American journal of physiology.

[11]  M BERMAN,et al.  THE FORMULATION AND TESTING OF MODELS , 1963, Annals of the New York Academy of Sciences.

[12]  R. Boston,et al.  Hormonal effects of norepinephrine on acute glucose disposal in humans: a minimal model analysis. , 1988, Metabolism: clinical and experimental.

[13]  R N Bergman,et al.  MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. , 1986, Computer methods and programs in biomedicine.

[14]  R C Boston,et al.  Conversational SAAM--an interactive program for kinetic analysis of biological systems. , 1981, Computer programs in biomedicine.

[15]  R. Rizza,et al.  Comparison of Insulin-mediated and Glucose-mediated Glucose Disposal in Patients with Insulin-dependent Diabetes Mellitus and in Nondiabetic Subjects , 1985, Diabetes.