Determination of Benzene and Toluene In Exhaled Cigarette Smoke

Abstract This study describes the results regarding the evaluation of retention efficiency by humans of benzene and toluene from cigarette smoke. The evaluated cigarette was a common commercial cigarette with 10.6 mg ‘tar’ [U.S. Federal Trade Commission (FTC) ‘tar’ is defined as the weight of total particulate matter minus nicotine and water]. The test was performed on ten subjects. The exhaled smoke was collected using a vacuum assisted technique that avoids strain in exhaling the smoke. The study showed that benzene was retained at levels of 89% to 98%, and toluene was retained at similar levels, between 87% and 99%. The lower limits of retention for both benzene and toluene are unexpectedly low compared to the retention of bi-and tricyclic aromatic hydrocarbons, which have retentions from cigarette smoke above 95%. This is probably caused by the fact that monocyclic aromatic hydrocarbons are present practically only in the vapor phase of cigarette smoke and at considerably higher levels than bi- and tri-cyclic aromatic hydrocarbons which are present almost completely in the particulate phase of cigarette smoke.

[1]  W. Coleman,et al.  Determination of Polycyclic Aromatic Hydrocarbons In Exhaled Cigarette Smoke , 2008 .

[2]  W. Coleman,et al.  Determination of Hydroxybenzenes in Exhaled Cigarette Smoke , 2008 .

[3]  S. Moldoveanu,et al.  Determination of Carbonyl Compounds in Exhaled Cigarette Smoke , 2007 .

[4]  S. Feng,et al.  A New Method for Estimating the Retention of Selected Smoke Constituents in the Respiratory Tract of Smokers During Cigarette Smoking , 2007, Inhalation toxicology.

[5]  S. Moldoveanu,et al.  Differences in the Chemical Composition of the Particulate Phase of Inhaled and Exhaled Cigarette Mainstream Smoke , 2007 .

[6]  R. Baker,et al.  The Retention of Tobacco Smoke Constituents in the Human Respiratory Tract , 2006, Inhalation toxicology.

[7]  M. Dixon,et al.  The Effect of Inhalation Volume and Breath-Hold Duration on the Retention of Nicotine and Solanesol in the Human Respiratory Tract and on Subsequent Plasma Nicotine Concentrations During Cigarette Smoking , 2004 .

[8]  D. Mariner,et al.  The effect of tobacco blend additives on the retention of nicotine and solanesol in the human respiratory tract and on subsequent plasma nicotine concentrations during cigarette smoking. , 2004, Chemical research in toxicology.

[9]  D. Bernstein,et al.  A Review of the Influence of Particle Size, Puff Volume, and Inhalation Pattern on the Deposition of Cigarette Smoke Particles in the Respiratory Tract , 2004, Inhalation toxicology.

[10]  S. Moldoveanu,et al.  Mainstream Smoke Chemical Analyses for 2R4F Kentucky Reference Cigarette , 2003 .

[11]  Risa J. Robinson,et al.  Deposition of Cigarette Smoke Particles in the Human Respiratory Tract , 2001 .

[12]  David M. Broday,et al.  Growth and Deposition of Hygroscopic Particulate Matter in the Human Lungs , 2001 .

[13]  S. Moldoveanu,et al.  A simple GC–MS technique for the analysis of vapor phase mainstream cigarette smoke , 2000 .

[14]  H. Chung,et al.  Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 1. Chemical composition of mainstream smoke. , 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[15]  A. Black,et al.  Environmental Tobacco Smoke Retention in Humans from Measurements of Exhaled Smoke Composition , 1994 .

[16]  G. B. Gori,et al.  Mouth versus deep airways absorption of nicotine in cigarette smokers , 1986, Pharmacology Biochemistry and Behavior.

[17]  M. First,et al.  A method for measuring respiratory deposition of cigarette smoke during smoking. , 1983, American Industrial Hygiene Association journal.

[18]  C. Dollery,et al.  Absorption and metabolism of nicotine from cigarettes. , 1975, British medical journal.

[19]  M. Rand,et al.  Cigarette Smoking and Plasma Levels of Nicotine , 1972, Nature.

[20]  J. Egle.  Retention of inhaled acetaldehyde in man. , 1970, The Journal of pharmacology and experimental therapeutics.

[21]  R. Rylander,et al.  Retention of cigarette smoke components in human lungs. , 1968, Archives of environmental health.

[22]  R. Rylander,et al.  Mouth absorption of various compounds in cigarette smoke. , 1968, Archives of environmental health.

[23]  W. L. Dennis.  Deposition of Inhaled Particles in Human Lungs , 1967, Nature.

[24]  M. Edfors,et al.  [TAR AND NICOTINE AMOUNTS IN CIGARETTE SMOKE]. , 1964, Nordisk hygienisk tidskrift.

[25]  M. F. Brunelle,et al.  Nitrogen oxide content of smokes from different types of tobacco. , 1959, A.M.A. archives of industrial health.