Spectral-domain Cirrus high-definition optical coherence tomography is better than time-domain Stratus optical coherence tomography for evaluation of macular pathologic features in uveitis.

PURPOSE To compare high-definition (HD) spectral-domain optical coherence tomography [SD-OCT] (Cirrus HD-OCT; Carl Zeiss, Dublin, California, USA) with time-domain optical coherence tomography [TD-OCT] (Stratus version 4; Carl Zeiss) for imaging macula in patients of uveitis. DESIGN Interventional case series. METHODS Thirty consecutive patients (51 eyes) with uveitis of various causes with vitreous haze of 1+ or worse were treated in an institutional setting. All patients had their vitreous haze graded and OCT scans both on TD-OCT (Stratus) and SD-OCT (Cirrus). Information obtained from Cirrus OCT scans was compared with that obtained from Stratus OCT scans. RESULTS Overall, for all grades of media clarity, the macula was interpreted as normal in 30 eyes (58.8%) on Stratus OCT and 26 eyes (50.9%) on Cirrus OCT and abnormal in 15 eyes (29.4%) on Stratus OCT and 24 eyes (47.0%) on Cirrus OCT, whereas poor scan quality deterred any interpretation in six eyes (10.0%) on Stratus OCT and only in one eye (1.8%) on Cirrus OCT. Additional information on Cirrus OCT could be obtained in nine (21.9%) of 41 eyes with grade 1+ vitreous haze, six (75%) of eight eyes with grade 2+ vitreous haze, and one eye (50%) with vitreous haze of 3+. CONCLUSIONS Our preliminary results suggest that SD Cirrus HD-OCT has an advantage over TD Stratus OCT in uveitic eyes by providing better identification of normal and pathologic structure in patients with poor media clarity.

[1]  U. Schmidt-Erfurth,et al.  Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases. , 2005, Investigative ophthalmology & visual science.

[2]  S. Kishi,et al.  Tomographic features of serous retinal detachment in Vogt-Koyanagi-Harada syndrome. , 2004, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.

[3]  R S Sobel,et al.  Fluorescein angiography complication survey. , 1986, Ophthalmology.

[4]  S. Kishi,et al.  Tomographic features of serous retinal detachment with multilobular dye pooling in acute Vogt-Koyanagi-Harada disease. , 2007, American journal of ophthalmology.

[5]  T. Schlote,et al.  [Optical coherence tomography in the diagnosis and follow-up of patients with uveitic macular edema]. , 2004, Der Ophthalmologe.

[6]  Marc D de Smet,et al.  Combined en-face optical coherence tomography and confocal ophthalmoscopy findings in active multifocal and serpiginous chorioretinitis. , 2006, American journal of ophthalmology.

[7]  Nathalie Cassoux,et al.  Retinal fluorescein and indocyanine green angiography and optical coherence tomography in successive stages of Vogt-Koyanagi-Harada disease , 2007, International Ophthalmology.

[8]  L. Morse,et al.  Vitreomacular traction syndrome following highly active antiretroviral therapy in AIDS patients with cytomegalovirus retinitis. , 1998 .

[9]  Dirk J. Faber,et al.  Recent developments in optical coherence tomography for imaging the retina , 2007, Progress in Retinal and Eye Research.

[10]  Teresa C. Chen,et al.  In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography. , 2004, Optics letters.

[11]  S. Sivaprasad,et al.  Tomographic assessment of therapeutic response to uveitic macular oedema , 2007, Clinical & experimental ophthalmology.

[12]  V. Peponis,et al.  Patterns of macular edema in patients with uveitis: qualitative and quantitative assessment using optical coherence tomography. , 2004, Ophthalmology.

[13]  C. Foster,et al.  The characteristic features of optical coherence tomography in posterior uveitis , 2007, British Journal of Ophthalmology.

[14]  R. Nussenblatt,et al.  Uveitis: Fundamentals and Clinical Practice , 1988 .

[15]  D. Chauhan,et al.  Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis. , 2000, Ophthalmology.

[16]  N. Markomichelakis,et al.  Course of Macular Edema in Uveitis under Medical Treatment , 2007, Ocular immunology and inflammation.

[17]  P. Sony,et al.  Macular thickness evaluation using the optical coherence tomography in normal Indian eyes. , 2004, Indian journal of ophthalmology.

[18]  Vishali Gupta,et al.  Atlas Optical Coherence Tomography of Macular Diseases and Glaucoma , 2006 .

[19]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.

[20]  L. Sobrin,et al.  Intravitreal bevacizumab for treatment of uveitic macular edema. , 2007, Ophthalmology.

[21]  M. Völker,et al.  Die optische Kohärenztomographie (OCT) als Diagnose- und Verlaufsparameter bei uveitisbedingtem Makulaödem , 2004, Der Ophthalmologe.