The quantum basis of spatiotemporality in perception and consciousness.

Living systems inhabit the area of the world which is shaped by the predictable space-time of physical objects and forces that can be incorporated into their perception pattern. The process of selecting a "habitable" space-time is the internal quantum measurement in which living systems become embedded into the environment that supports their living state. This means that living organisms choose a coordinate system in which the influence of measurement is minimal. We discuss specific roles of biological macromolecules, in particular of the cytoskeleton, in shaping perception patterns formed in the internal measurement process. Operation of neuron is based on the transmission of signals via cytoskeleton where the digital output is generated that can be decoded through a reflective action of the perceiving agent. It is concluded that the principle of optimality in biology as formulated by Liberman et al. (BioSystems 22, 135-154, 1989) is related to the establishment of spatiotemporal patterns that are maximally predictable and can hold the living state for a prolonged time. This is achieved by the selection of a habitable space approximated to the conditions described by classical physics.

[1]  D. Poeppel,et al.  Cortical Tracking of Hierarchical Linguistic Structures in Connected Speech , 2015, Nature Neuroscience.

[2]  E. Liberman,et al.  Quantum molecular computer model of the neuron and a pathway to the union of the sciences. , 1989, Bio Systems.

[3]  Andrei Khrennikov,et al.  Quantum-like model of cognitive decision making and information processing , 2009, Biosyst..

[4]  I. N. Marshall Consciousness and Bose-Einstein condensates , 1989 .

[5]  K Matsuno,et al.  Quantum and biological computation. , 1995, Bio Systems.

[6]  Y. Orlov,et al.  The wave logic of consciousness: A hypothesis , 1982 .

[7]  Jack Tuszynski,et al.  Conduction pathways in microtubules, biological quantum computation, and consciousness. , 2002, Bio Systems.

[8]  Koichiro Matsuno Chemical evolution as a concrete scheme for naturalizing the relative-state of quantum mechanics , 2012, Biosyst..

[9]  Alexey V. Melkikh,et al.  Congenital programs of the behavior and nontrivial quantum effects in the neurons work , 2014, Biosyst..

[10]  Koichiro Matsuno,et al.  Forming and maintaining a heat engine for quantum biology. , 2006, Bio Systems.

[11]  S. Petukhov Non-Euclidean geometries and algorithms of living bodies , 1989 .

[12]  Daniel Havelka,et al.  Mechano-electrical vibrations of microtubules - Link to subcellular morphology , 2012, Biosyst..

[13]  E. Kandel,et al.  Memory suppressor genes: inhibitory constraints on the storage of long-term memory. , 1998, Science.

[14]  A. Igamberdiev Semiokinesis Semiotic autopoiesis of the Universe , 2001 .

[15]  G. Leibniz,et al.  Monadology and Other Philosophical Essays , 1965 .

[16]  Susan S. Taylor,et al.  Using Markov State Models to Develop a Mechanistic Understanding of Protein Kinase A Regulatory Subunit RIα Activation in Response to cAMP Binding* , 2014, The Journal of Biological Chemistry.

[17]  Quantum mechanics in first, second and third person descriptions. , 2003, Bio Systems.

[18]  K Matsuno Internalist stance and the physics of information. , 1996, Bio Systems.

[19]  A. Igamberdiev Semiosis and reflectivity in life and consciousness , 1999 .

[20]  I. Kant,et al.  Critique of Pure Reason: Glossary , 1998 .

[21]  J. Mattick RNA as the substrate for epigenome‐environment interactions , 2010 .

[22]  Peng Shang,et al.  cDNA microarray reveals the alterations of cytoskeleton-related genes in osteoblast under high magneto-gravitational environment. , 2009, Acta biochimica et biophysica Sinica.

[23]  J. Tuszynski,et al.  Keeping time: could quantum beating in microtubules be the basis for the neural synchrony related to consciousness? , 2014, Journal of integrative neuroscience.

[24]  Yoshiharu Tanaka,et al.  Quantum Information Biology: From Information Interpretation of Quantum Mechanics to Applications in Molecular Biology and Cognitive Psychology , 2015, Foundations of Physics.

[25]  Andrei Khrennikov,et al.  Quantum-like model of partially directed evolution. , 2017, Progress in biophysics and molecular biology.

[26]  Vasileios Basios,et al.  Quantum cognition based on an ambiguous representation derived from a rough set approximation , 2014, Biosyst..

[27]  S. M. Huisman,et al.  Phosphorylation of Spc110p by Cdc28p-Clb5p kinase contributes to correct spindle morphogenesis in S. cerevisiae , 2007, Journal of Cell Science.

[28]  Michael B. Mensky,et al.  Everett Interpretation and Quantum Concept of Consciousness , 2013 .

[29]  Vasileios Basios,et al.  Inverse Bayesian inference as a key of consciousness featuring a macroscopic quantum logical structure , 2017, Biosyst..

[30]  S. Hameroff Consciousness, the Brain, and Spacetime Geometry , 2001, Annals of the New York Academy of Sciences.

[31]  Sergey V. Petoukhov The system-resonance approach in modeling genetic structures , 2016, Biosyst..

[32]  K. Thorne,et al.  Quantum Nondemolition Measurements , 1980, Science.

[33]  P. Hussey,et al.  Arp2/3 and 'the shape of things to come'. , 2003, Current opinion in plant biology.

[34]  E A Liberman,et al.  Biological information and laws of nature. , 1998, Bio Systems.

[35]  E. Schrödinger What Is Life , 1946 .

[36]  Liberman Ea Molecular computers in cells. I. General considerations and hypotheses , 1972 .

[37]  M. Pellegrino,et al.  Regulation of the mechanosensitive cation channels by ATP and cAMP in leech neurons. , 2006, Biochimica et biophysica acta.

[38]  Zareen Amtul,et al.  Neural Plasticity and Memory , 2016, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[39]  Yukio-Pegio Gunji,et al.  Sociality of an agent during morphogenetic canalization: Asynchronous updating with potential resonance , 2012, Biosyst..

[40]  D. Bohm,et al.  Wholeness and the Implicate Order , 1981 .

[41]  Nikita E. Shklovskiy-Kordi,et al.  Computational power and generative capacity of genetic systems , 2016, Biosyst..

[42]  S. B. Jameie,et al.  Immune and Nervous Systems Share Molecular and Functional Similarities: Memory Storage Mechanism , 2009, Scandinavian journal of immunology.

[43]  The action uncertainty principle and quantum gravity , 1992 .

[44]  Avner Priel,et al.  Microtubule ionic conduction and its implications for higher cognitive functions. , 2010, Journal of integrative neuroscience.

[45]  E A Liberman,et al.  Cell molecular computers and biological information as the foundation of nature's laws. , 1996, Bio Systems.

[46]  E A Liberman,et al.  Analog-digital molecular cell computer. , 1979, Bio Systems.

[47]  E. Liberman,et al.  Molecular quantum computer of neuron. , 1995, Bio Systems.

[48]  Jonathan Y. Mane,et al.  The feasibility of coherent energy transfer in microtubules , 2014, Journal of The Royal Society Interface.

[49]  Abir U. Igamberdiev,et al.  Biomechanical and coherent phenomena in morphogenetic relaxation processes , 2012, Biosyst..

[50]  Michael Conrad,et al.  Neuron generator potentials evoked by intracellular injection of cyclic nucleotides and mechanical distension , 1985, Brain Research.

[51]  J. Nemes,et al.  Erratum: The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1) (Human Molecular Genetics (2000) vol. 9 (1543-1551)) , 2000 .

[52]  Y. Arshavsky,et al.  Cellular and network properties in the functioning of the nervous system: from central pattern generators to cognition , 2003, Brain Research Reviews.

[53]  S. Schiller,et al.  Quantum non-demolition measurements , 1995 .

[54]  Yoshiharu Tanaka,et al.  Quantum Adaptivity in Biology: From Genetics to Cognition , 2015, Springer Netherlands.

[55]  Noam Chomsky,et al.  Evolution, brain, and the nature of language , 2013, Trends in Cognitive Sciences.

[56]  Martin Heidegger,et al.  Ponderings II–VI: Black Notebooks 1931–1938 , 2016 .

[57]  Geometrical modification of quaternionic quantum mechanics , 2007, math-ph/0702095.

[58]  Andrei Khrennikov,et al.  Quantum-like model of processing of information in the brain based on classical electromagnetic field , 2010, Biosyst..

[59]  L. Bonini The Extended Mirror Neuron Network , 2017, The Neuroscientist.

[60]  R. Gordon,et al.  The cytoskeletal mechanics of brain morphogenesis , 1987, Cell Biophysics.

[61]  Jan Martin Nordbotten,et al.  Asymmetric ecological conditions favor Red-Queen type of continued evolution over stasis , 2016, Proceedings of the National Academy of Sciences.

[62]  Abir U. Igamberdiev,et al.  Time rescaling and pattern formation in biological evolution , 2014, Biosyst..

[63]  M. Cifra,et al.  High-frequency electric field and radiation characteristics of cellular microtubule network. , 2011, Journal of theoretical biology.

[64]  Koichiro Matsuno Self-identities and durability of biosystems via their abstracting capacity , 2014, Biosyst..

[65]  Andreas Wichert,et al.  Quantum-Like Bayesian Networks for Modeling Decision Making , 2016, Front. Psychol..

[66]  E. Husserl,et al.  On the phenomenology of the consciousness of internal time (1893-1917) , 1991 .

[67]  Andrei Khrennikov,et al.  Quantum formalism as an optimisation procedure of information flows for physical and biological systems , 2016, Biosyst..

[68]  Tomoko Sakiyama,et al.  Emergent weak home-range behaviour without spatial memory , 2016, Royal Society Open Science.

[69]  R. Rosen Life Itself: A Comprehensive Inquiry Into the Nature, Origin, and Fabrication of Life , 1991 .

[70]  H. Stapp Consciousness and values in the quantum universe , 1985 .

[71]  Yoshiharu Tanaka,et al.  Quantum-like generalization of the Bayesian updating scheme for objective and subjective mental uncertainties , 2012 .

[72]  M. Arbib Co‐Evolution of Human Consciousness and Language , 2001, Annals of the New York Academy of Sciences.

[73]  J. Tuszynski,et al.  On the possible quantum role of serotonin in consciousness. , 2015, Journal of integrative neuroscience.

[74]  J. Kemp,et al.  The World As Will And Idea , 1975 .

[75]  Abir U. Igamberdiev,et al.  Physical limits of computation and emergence of life , 2007, Biosyst..

[76]  Koji Sawa,et al.  The Double Homunculus model of self-reflective systems , 2016, Biosyst..

[77]  J. Tuszynski,et al.  Analysis of the strength of interfacial hydrogen bonds between tubulin dimers using quantum theory of atoms in molecules. , 2014, Biophysical journal.

[78]  Pedro C. Marijuán,et al.  On eukaryotic intelligence: Signaling system's guidance in the evolution of multicellular organization , 2013, Biosyst..

[79]  Atta-ur-rahman,et al.  Neural plasticity and memory: molecular mechanism , 2015, Reviews in the neurosciences.

[80]  Vasily Ogryzko,et al.  Quantum biology at the cellular level - Elements of the research program , 2013, Biosyst..

[81]  J. Acacio de Barros,et al.  Quantum-like model of behavioral response computation using neural oscillators , 2012, Biosyst..

[82]  J. Nemes,et al.  The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1). , 2000, Human molecular genetics.

[83]  C. Potter,et al.  Organization of olfactory centres in the malaria mosquito Anopheles gambiae , 2016, Nature Communications.

[84]  Andrei Khrennikov,et al.  Nontrivial quantum and quantum-like effects in biosystems: Unsolved questions and paradoxes. , 2015, Progress in biophysics and molecular biology.

[85]  A. Mogilner,et al.  Analysis of the local organization and dynamics of cellular actin networks , 2013, The Journal of cell biology.

[86]  J. Kineman RELATIONAL SELF-SIMILAR SPACE-TIME COSMOLOGY REVISITED , 2010 .

[87]  Abir U Igamberdiev,et al.  Quantum computation, non-demolition measurements, and reflective control in living systems. , 2004, Bio Systems.

[88]  N. Bohr II - Can Quantum-Mechanical Description of Physical Reality be Considered Complete? , 1935 .

[89]  D. McCormick,et al.  α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex , 2007, Cell.

[90]  A U Igamberdiev,et al.  Quantum mechanical properties of biosystems: a framework for complexity, structural stability, and transformations. , 1993, Bio Systems.

[91]  M. Arbib Toward the Language-Ready Brain: Biological Evolution and Primate Comparisons , 2016, Psychonomic Bulletin & Review.

[92]  Aristotle The Complete Works Of Aristotle , 1954 .

[93]  Noam Chomsky,et al.  How Could Language Have Evolved? , 2014, PLoS biology.

[94]  GR-Friendly Description of Quantum Systems , 2008 .

[95]  R. MacGregor Quantum mechanics and brain uncertainty. , 2006, Journal of integrative neuroscience.

[96]  Jaegwon Kim,et al.  Philosophy of Mind , 1996 .

[97]  A. Igamberdiev Relational Universe of Leibniz : Implications for Modern Physics and Biology , 2015 .

[98]  Noam Chomsky,et al.  Language: UG or Not to Be, That Is the Question , 2015, PLoS biology.

[99]  Yoshiharu Tanaka,et al.  Quantum-like model of brain's functioning: decision making from decoherence. , 2011, Journal of theoretical biology.

[100]  Abir U. Igamberdiev Objective patterns in the evolving network of non-equivalent observers , 2008, Biosyst..

[101]  N. V. van Hulst,et al.  Quantum Coherent Energy Transfer over Varying Pathways in Single Light-Harvesting Complexes , 2013, Science.

[102]  C. Farnum,et al.  Axonemal positioning and orientation in three‐dimensional space for primary cilia: What is known, what is assumed, and what needs clarification , 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

[103]  M. Arbib Co-evolution of human consciousness and language (revisited). , 2014, Journal of integrative neuroscience.

[104]  Yukio-Pegio Gunji,et al.  Dialogue and causality: Global description from local observations and vague communications , 2007, Biosyst..

[105]  Masanori Ohya,et al.  A model of epigenetic evolution based on theory of open quantum systems , 2013, Systems and Synthetic Biology.

[106]  Roger Penrose,et al.  Orchestrated reduction of quantum coherence in brain microtubules: a model for consciousness , 1996 .

[107]  I. Egorov Neural logic molecular, counter-intuitive. , 2007, Biomolecular engineering.

[108]  A. Hodgkin,et al.  Movements of labelled calcium in squid giant axons , 1957, The Journal of physiology.

[109]  S. Hameroff,et al.  Quantum computation in brain microtubules: decoherence and biological feasibility. , 2000, Physical review. E, Statistical, nonlinear, and soft matter physics.

[110]  M. Mensky Time in quantum cosmology from the self-measurement of the universe , 1991 .

[111]  Georges Rey Philosophy of mind. , 2006, Wiley interdisciplinary reviews. Cognitive science.

[112]  L. DesGroseillers,et al.  Understanding the importance of mRNA transport in memory. , 2008, Progress in brain research.

[113]  M. Deriu,et al.  Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model , 2014, PloS one.

[114]  J. Mattick,et al.  Long non-coding RNAs in nervous system function and disease , 2010, Brain Research.

[115]  Liberman Ea,et al.  Molecular computer. Biological physics and physics of the real world , 1978 .

[116]  I. M. Santalova,et al.  Experimental testing of the role of cytoskeleton in the solution by neurons of problems facing the brain , 2008, Biochemistry (Moscow).

[117]  S Ji,et al.  The cell as the smallest DNA-based molecular computer. , 1999, Bio Systems.

[118]  S Ji,et al.  Isomorphism between cell and human languages: molecular biological, bioinformatic and linguistic implications. , 1997, Bio Systems.

[119]  John J. Kineman R‐Theory: A Synthesis of Robert Rosen's Relational Complexity , 2012 .