A hydrodynamic model for hindered diffusion of proteins and micelles in hydrogels.

Recently, several papers have been published that address the important topic of hindered diffusion of macromolecules in hydrogels. Two papers in particular, by Johnson et al. (1996) and Clague and Phillips (1996), present models of hindered diffusion that account for hydrodynamic interactions, albeit in different ways. The model of Johnson et al. (1996) makes use of an effective medium approach based on Brinkman's equation, whereas Clague and Phillips (1996) explicitly calculate those interactions for a spherical solute suspended in a liquid-filled, three-dimensional medium of randomly placed cylindrical fibers.

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