A Case of Hyalinizing Trabecular Adenoma of the Thyroid Gland

Hyalinizing trabecular tumor is a rare benign thyroid tumor first described by Carney et al. in 1987. The tumor is characterized by an encapsulated nodule, trabecular arrangement of polygonal, oval, elongated cells, and hyalinized stroma. It is easily confused with papillary thyroid carcinoma or medullary thyroid carcinoma on surgical and cytologic specimens. A 45-year-old man presented with an incidentally detected left thyroid mass. Fine needle aspiration was performed and papillary thyroid carcinoma was suspected. However, the surgical specimen revealed a hyalinizing trabecular adenoma. We present this hyalinizing trabecular adenoma case to share our experience with physicians and specialists. (J Korean Endocr Soc 24:54~57, 2009)

[1]  M. Papotti,et al.  Hyalinizing Trabecular Tumors of the Thyroid Gland are Almost all Benign , 2008, The American journal of surgical pathology.

[2]  S. Gowrishankar,et al.  Hyalinizing trabecular carcinoma of the thyroid gland , 2008, Histopathology.

[3]  M. Papotti,et al.  Hyalinizing Trabecular Tumor of the Thyroid: An Update , 2008, Endocrine pathology.

[4]  S. Mendrinos,et al.  Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. , 2007, American journal of surgery.

[5]  G. Chiappetta,et al.  Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations. , 2005, European journal of cancer.

[6]  T. Sebo,et al.  Hyalinizing trabecular adenoma of the thyroid gland identification through MIB-1 staining of fine-needle aspiration biopsy smears. , 2004, American journal of clinical pathology.

[7]  김석원,et al.  갑상선의 유리질화 섬유주 선종 , 2003 .

[8]  M. Hirokawa,et al.  Cytologic Features of Hyalinizing Trabecular Adenoma of the Thyroid , 2003, Acta Cytologica.

[9]  G. Chiappetta,et al.  RET/PTC Activation in Hyalinizing Trabecular Tumors of the Thyroid , 2000, The American journal of surgical pathology.

[10]  M. Hirokawa,et al.  Hyalinizing trabecular adenoma and papillary carcinoma of the thyroid gland express different cytokeratin patterns. , 2000, The American journal of surgical pathology.

[11]  M. Hirokawa,et al.  Cell membrane and cytoplasmic staining for MIB-1 in hyalinizing trabecular adenoma of the thyroid gland. , 2000, The American journal of surgical pathology.

[12]  Moon-Hyang Park,et al.  Fine Needle Aspiration Cytology of the Hyalinizing Trabecular Adenoma of the Thyroid Gland: A Case Report. , 1999 .

[13]  J. Rosai,et al.  Thyroid paraganglioma: a clinicopathologic and immunohistochemical study of three cases. , 1997, The American journal of surgical pathology.

[14]  J. Sloan,et al.  Hyalinizing trabecular carcinoma of thyroid gland , 1996, Histopathology.

[15]  T. Manabe,et al.  Hyalinizing trabecular adenoma of the thyroid: Its unusual cytoplasmic immunopositivity for MIB1 , 1995, Pathology international.

[16]  K. Molberg,et al.  Hyalinizing trabecular carcinoma of the thyroid gland. , 1994, Human pathology.

[17]  A. Matsumoto,et al.  [Hyalinizing trabecular adenoma of the thyroid]. , 1993, Nihon Geka Gakkai zasshi.

[18]  K. Franssila,et al.  Hyalinizing trabecular adenoma: A misnomer for a peculiar tumor of the thyroid gland , 1991, Endocrine Pathology.

[19]  J. Carney,et al.  Hyalinizing Trabecular Adenoma of the Thyroid Gland , 1987, The American journal of surgical pathology.