Adverse drug reactions in hospital in‐patients: a pilot study

Background:  About 6·5% of admissions to hospital are related to an adverse drug reaction (ADR). There are no recent large studies, which explore the burden of ADRs on hospital in‐patients. The aim of this pilot study was to assess the feasibility of, and establish the methodology for, conducting a large prospective study to fully assess the impact of ADRs on in‐patients and the National Health Service (NHS).

[1]  H. Jick,et al.  Drug monitoring of surgical patients. , 1982, JAMA.

[2]  R S Evans,et al.  Preventing Adverse Drug Events in Hospitalized Patients , 1994, The Annals of pharmacotherapy.

[3]  L. Cluff,et al.  Studies on the epidemiology of adverse drug reactions. V. Clinical factors influencing susceptibility. , 1966, Annals of internal medicine.

[4]  J. Hallas,et al.  Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention , 1990, Journal of internal medicine.

[5]  R F Moulds,et al.  Hospitalisation for adverse events related to drug therapy: incidence, avoidability and costs , 1996, The Medical journal of Australia.

[6]  K. Gholami,et al.  Factors Associated with Preventability, Predictability, and Severity of Adverse Drug Reactions , 1999, The Annals of pharmacotherapy.

[7]  T. Brennan,et al.  The nature of adverse events in hospitalized patients. Results of the Harvard Medical Practice Study II. , 1991, The New England journal of medicine.

[8]  C. Simmons,et al.  ADVERSE DRUG REACTIONS : CAN WE REDUCE THE RISK? , 1998 .

[9]  D. Classen,et al.  Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. , 1997, JAMA.

[10]  N Hurwitz,et al.  Intensive Hospital Monitoring of Adverse Reactions to Drugs , 1969, British medical journal.

[11]  M Simmons,et al.  Adverse drug reactions during hospitalization. , 1968, Canadian Medical Association journal.

[12]  L. Bowman,et al.  Adverse drug reaction (ADR) occurrence and evaluation in elderly inpatients , 1996, Pharmacoepidemiology and drug safety.

[13]  J. Edwards,et al.  Extra Adverse drug reactions in hospital patients A systematic review of the prospective and retrospective studies , 2002 .

[14]  P. Routledge,et al.  Adverse drug reactions in elderly patients. , 2003, British journal of clinical pharmacology.

[15]  M. Rawlins.  Pathogenesis of adverse drug reactions , 1977 .

[16]  P T Davis.  Adverse drug events in hospitalized patients. , 1997, JAMA.

[17]  I. Edwards,et al.  Adverse drug reactions: definitions, diagnosis, and management , 2000, The Lancet.

[18]  M. Pirmohamed,et al.  Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients , 2004, BMJ : British Medical Journal.

[19]  D. Greenblatt,et al.  A method for estimating the probability of adverse drug reactions , 1981, Clinical pharmacology and therapeutics.

[20]  P. Schneider,et al.  Preventability and severity assessment in reporting adverse drug reactions. , 1992, American journal of hospital pharmacy.

[21]  L. Cluff,et al.  EPIDEMIOLOGICAL STUDIES OF ADVERSE DRUG REACTIONS. , 1965, American journal of public health and the nation's health.

[22]  J. Venulet,et al.  Methods for monitoring and documenting adverse drug reactions. , 1996, International journal of clinical pharmacology and therapeutics.

[23]  J. Hayes,et al.  Frequency and Preventability of Adverse Drug Reactions in Paediatric Patients , 2004, Drug safety.

[24]  M. Levy.  Pharmacologic treatment of cancer pain. , 1996, The New England journal of medicine.

[25]  P. Talwar.  Developing indices of nutritional level from anthropometric measurements on women and young children. , 1975, American journal of public health.

[26]  N. Moore,et al.  Frequency and cost of serious adverse drug reactions in a department of general medicine. , 1998, British journal of clinical pharmacology.