Biotin supplements and laboratory test results in neuropsychiatric practice and research

Li et al.[10] examined the performance of specific biotinylated immunoassays in a nonrandomized crossover trial conducted in 6 healthy adults who received supplementation with oral biotin. The mean age of the sample was 38 years. The sample was 33% female. No participant was receiving nutritional supplements. These participants were administered oral biotin in the dose of 10 mg/day for 1 week. Whereas this dose is very high, being >300 times the daily intake guidance,[10] it was chosen because it is common in over-the-counter supplements, and because doses of 10 mg/day and higher are common when biotin is prescribed in dermatological, medical, or neuropsychiatric conditions.