Deep brain stimulation in movement disorders. The applications reconsidered.

In this study the role of DBS in advanced Parkinson disease (PD) is re-evaluated and new indications in the field of movement disorders are explored. The authors performed unilateral pallidal stimulation in 26 patients with advanced PD. At long-term follow-up review, the motor effect is unsatisfying. The authors conclude that unilateral pallidal stimulation is not a favourable treatment option for patients with advanced PD. Bilateral subthalamic nucleus stimulation was performed in twenty patients with advanced PD. After a minimum follow-up of 4 years, there was still a significant improvement in motor function and functional performance in all patients. One side-effect of the stimulation was however rather concerning: four patients presented with stimulation-induced hypomanic to manic characteristics. Bilateral subthalamic stimulation was performed in four patients with multiple system atrophy-parkinsonism. At long-term follow-up, the patients fared better with than without stimulation. The authors finally present a completely new indication for DBS: Tourette syndrome (TS). They review the literature on surgical procedures performed in TS, all of which consisted of making lesions. Three TS patients are presented on which bilateral thalamic stimulation was performed. At long-term follow-up, all major tics had disappeared, as well as associated behavioral disturbances.

[1]  A. Benabid,et al.  Long-term effects of chronic stimulation of the ventral intermediate thalamic nucleus in different types of tremor. , 1993, Advances in neurology.

[2]  L. Defebvre,et al.  Influence of chronic bilateral stimulation of the subthalamic nucleus on cognitive function in Parkinson's disease , 2001, Journal of Neurology.

[3]  J. Jankovic,et al.  Tourette's syndrome. , 2001, The New England journal of medicine.

[4]  B. Schmand,et al.  Unilateral pallidotomy in Parkinson's disease: a randomised, single-blind, multicentre trial , 1999, The Lancet.

[5]  A L Benabid,et al.  Subthalamic nucleus or internal pallidal stimulation in young onset Parkinson's disease. , 1998, Brain : a journal of neurology.

[6]  Jens Volkmann,et al.  Bilateral high-frequency stimulation in the subthalamic nucleus for the treatment of Parkinson disease: correlation of therapeutic effect with anatomical electrode position. , 2002, Journal of neurosurgery.

[7]  J. Coyle,et al.  Dopaminergic dysfunction in tourette syndrome , 1982 .

[8]  A. Benabid,et al.  Effect of subthalamic nucleus stimulation on levodopa-induced dyskinesia in Parkinson’s disease , 2000, Neurology.

[9]  M. Hariz,et al.  A 10-year follow-up review of patients who underwent Leksell's posteroventral pallidotomy for Parkinson disease. , 2001, Journal of neurosurgery.

[10]  L. Lisý,et al.  Experiences with dentatotomy. , 1972, Confinia neurologica.

[11]  C. Marsden,et al.  Recent Developments in Parkinson's Disease , 1986 .

[12]  M. Hariz,et al.  Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. , 1992, Journal of neurosurgery.

[13]  W. Poewe,et al.  Towards Neurotransplantation in Multiple System Atrophy: Clinical Rationale, Pathophysiological Basis, and Preliminary Experimental Evidence , 2000, Cell transplantation.

[14]  J. Bogdanowicz,et al.  REPORT OF THREE CASES. , 1963, American journal of diseases of children.

[15]  A. Lozano,et al.  Vim thalamic stimulation for tremor. , 2000, Archives of medical research.

[16]  J. Jankovic,et al.  Concepts and Methods in Chronic Thalamic Stimulation for Treatment of Tremor: Technique and Application , 2001, Neurosurgery.

[17]  Ann M Graybiel,et al.  Toward a Neurobiology of Obsessive-Compulsive Disorder , 2000, Neuron.

[18]  A. Bonnet,et al.  [The Unified Parkinson's Disease Rating Scale]. , 2000, Revue neurologique.

[19]  D. Cohen,et al.  Severe disturbances in speech, swallowing, and gait following stereotactic infrathalamic lesions in Gilles de la Tourette's syndrome , 1993, Neurology.

[20]  P. Warnke,et al.  Immediate and long term outcome after infrathalamic and thalamic lesioning for intractable Tourette's syndrome , 2001, Journal of neurology, neurosurgery, and psychiatry.

[21]  Krishna Kumar,et al.  Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus for Control of Tremors in Parkinson’s Disease and Essential Tremor , 2000, Stereotactic and Functional Neurosurgery.

[22]  A M Graybiel,et al.  The neurobiology of repetitive behaviors: clues to the neurobiology of Tourette syndrome. , 2001, Advances in neurology.

[23]  J. Mink.  THE BASAL GANGLIA: FOCUSED SELECTION AND INHIBITION OF COMPETING MOTOR PROGRAMS , 1996, Progress in Neurobiology.

[24]  M. Trimble,et al.  The treatment of Gilles de la Tourette syndrome by limbic leucotomy. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[25]  Y. Agid,et al.  Pallidal stimulation for Parkinson's disease , 1997, Neurology.

[26]  Sube Banerjee,et al.  The prevalence of Tourette syndrome in 13-14-year-olds in mainstream schools. , 2001, Journal of child psychology and psychiatry, and allied disciplines.

[27]  S. Rauch,et al.  Neuroimaging Studies in Tourette Syndrome , 1999, CNS Spectrums.

[28]  H. Groenewegen,et al.  The specificity of the ‘nonspecific’ midline and intralaminar thalamic nuclei , 1994, Trends in Neurosciences.

[29]  S. Leurgans,et al.  Home alone: Methods to maximize tic expression for objective videotape assessments in Gilles de la Tourette syndrome , 2001, Movement disorders : official journal of the Movement Disorder Society.

[30]  D. Eidelberg,et al.  Effects of posteroventral pallidotomy on Parkinson's disease. , 1996, Advances in neurology.

[31]  J. Nathanson,et al.  Central biogenic amine metabolism in children with the syndrome of chronic multiple tics of Gilles de la Tourette: norepinephrine, serotonin, and dopamine. , 1979, Journal of the American Academy of Child Psychiatry.

[32]  W. Steers.  Neural pathways and central sites involved in penile erection: neuroanatomy and clinical implications , 2000, Neuroscience & Biobehavioral Reviews.

[33]  I Litvan,et al.  Consensus statement on the diagnosis of multiple system atrophy , 1998, Journal of the Neurological Sciences.

[34]  R. J. Helscher,et al.  Apomorphine test: a predictor for motor responsiveness to deep brain stimulation of the subthalamic nucleus , 1999, Journal of Neurology.

[35]  Z. Tian,et al.  Prevention of Neurotoxin Damage of 6-OHDA to Dopaminergic Nigral Neuron by Subthalamic Nucleus Lesions , 2001, Stereotactic and Functional Neurosurgery.

[36]  J. Coyle,et al.  Dopaminergic dsyfunction in Tourette syndrome. , 1982, Annals of neurology.

[37]  Z. Schwab,et al.  Projection technique for evaluating surgery in Parkinson’s disease , 1969 .

[38]  Y Agid,et al.  Subthalamic stimulation in Parkinson disease: a multidisciplinary approach. , 2000, Archives of neurology.

[39]  D. Brooks,et al.  Core assessment program for intracerebral transplantations (CAPIT) , 1992, Movement disorders : official journal of the Movement Disorder Society.

[40]  U. Asam,et al.  [Gilles de la Tourette syndrome and psychosurgery]. , 1981, Acta paedopsychiatrica.

[41]  V. Visser-Vandewalle,et al.  Surgery in Tourette syndrome , 2004, Movement disorders : official journal of the Movement Disorder Society.

[42]  Yasin Temel,et al.  Bilateral high-frequency stimulation of the subthalamic nucleus in patients with multiple system atrophy--parkinsonism. Report of four cases. , 2003, Journal of neurosurgery.

[43]  A. Benabid,et al.  Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease. , 1998, The New England journal of medicine.

[44]  Richard S. J. Frackowiak,et al.  Changes in cerebral activity pattern due to subthalamic nucleus or internal pallidum stimulation in Parkinson's disease , 1997, Annals of neurology.

[45]  J. Mink.  Basal ganglia dysfunction in Tourette's syndrome: a new hypothesis. , 2001, Pediatric neurology.

[46]  J. Jankovic.  Tourette syndrome. Phenomenology and classification of tics. , 1997, Neurologic clinics.

[47]  C. N. Still.  INVOLUNTARY MOVEMENT DISORDERS , 1984, Neurologic clinics.

[48]  A. Lang,et al.  Long-term follow-up of unilateral pallidotomy in advanced Parkinson's disease. , 2000, The New England journal of medicine.

[49]  C. Marsden.  The mysterious motor function of the basal ganglia , 1982, Neurology.

[50]  S. Rauch,et al.  Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods. , 2001, Advances in neurology.

[51]  J. Taha,et al.  Outcome of unilateral and bilateral pallidotomy for Parkinson's disease: patient assessment. , 2000, Neurosurgery.

[52]  Paul Krack,et al.  Mirthful laughter induced by subthalamic nucleus stimulation , 2001, Movement disorders : official journal of the Movement Disorder Society.

[53]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.

[54]  E. Chee,et al.  Volumetric MRI changes in basal ganglia of children with Tourette's syndrome , 1993, Neurology.

[55]  R. Esselink,et al.  Bilateral pallidotomy in Parkinson's disease: A retrospective study , 2002, Movement disorders : official journal of the Movement Disorder Society.

[56]  J. Cummings,et al.  Gilles de la Tourette syndrome and the neurological basis of obsessions and compulsions , 1985, Biological Psychiatry.

[57]  M Loyo-Varela,et al.  Pallidotomy in Parkinson's disease. , 1996, Neurosurgery.

[58]  A. Bentivoglio,et al.  Multiple system atrophy presenting as parkinsonism: clinical features and diagnostic criteria. , 1995, Journal of neurology, neurosurgery, and psychiatry.

[59]  A. Shapiro,et al.  Treatment of Tourette's syndrome with haloperidol, review of 34 cases. , 1973, Archives of general psychiatry.

[60]  V. Visser-Vandewalle,et al.  Deep brain stimulation of the thalamus can influence penile erection , 2004, International Journal of Impotence Research.

[61]  G. Solomon,et al.  Neurological features of Gilles de la Tourette's syndrome , 1973, Journal of neurology, neurosurgery, and psychiatry.

[62]  A. Antonini,et al.  Preoperative indicators of clinical outcome following stereotaxic pallidotomy , 1997, Neurology.

[63]  A. Lozano,et al.  Comparative effects of unilateral and bilateral subthalamic nucleus deep brain stimulation , 1999, Neurology.

[64]  Richard S. J. Frackowiak,et al.  The metabolic effects of limbic leucotomy in Gilles de la Tourette syndrome. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[65]  Definitions and classification of tic disorders. The Tourette Syndrome Classification Study Group. , 1993, Archives of neurology.

[66]  I. S. Cooper.  Dystonia reversal by operation on basal ganglia. , 1962, Archives of neurology.

[67]  J. Kulisevsky,et al.  Mania following deep brain stimulation for Parkinson's disease. , 2002, Neurology.

[68]  Paresh K Doshi,et al.  Depression leading to attempted suicide after bilateral subthalamic nucleus stimulation for Parkinson's disease , 2002, Movement disorders : official journal of the Movement Disorder Society.

[69]  F. Alesch,et al.  Stimulation of the ventral intermediate thalamic nucleus in tremor dominated Parkinson's disease and essential tremor , 2005, Acta Neurochirurgica.

[70]  O. Devinsky,et al.  Stereotactic ventral pallidotomy for Parkinson's disease , 1995, Neurology.

[71]  V. Vandewalle,et al.  Mitotic activity in cerebrospinal fluid cells , 1988, Clinical Neurology and Neurosurgery.

[72]  P. Bossuyt,et al.  A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. , 2000, The New England journal of medicine.

[73]  P. Redgrave,et al.  The basal ganglia: a vertebrate solution to the selection problem? , 1999, Neuroscience.

[74]  S. Rauch,et al.  Cingulotomy for intractable obsessive-compulsive disorder : prospective long-term follow-up of 18 patients , 1995 .

[75]  K J Burchiel,et al.  Comparison of pallidal and subthalamic nucleus deep brain stimulation for advanced Parkinson's disease: results of a randomized, blinded pilot study. , 1999, Neurosurgery.

[76]  M. Lévesque,et al.  Subthalamic Stimulation in Parkinson’s Disease , 2000, Stereotactic and Functional Neurosurgery.

[77]  M. Witter,et al.  The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness , 2002, Brain Research Reviews.

[78]  T. Aziz,et al.  Lesion of the subthalamic nucleus for the alleviation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced parkinsonism in the primate , 1991, Movement disorders : official journal of the Movement Disorder Society.

[79]  Unilateral pallidotomy for advanced Parkinson's disease. , 1999, Brain : a journal of neurology.

[80]  Peter Herscovitch,et al.  The Functional Neuroanatomy of Tourette's Syndrome: An FDG-PET Study. I. Regional Changes in Cerebral Glucose Metabolism Differentiating Patients and Controls , 1993, Neuropsychopharmacology.

[81]  Henk J Groenewegen,et al.  Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome. Report of three cases. , 2003, Journal of neurosurgery.

[82]  A. Benabid,et al.  Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. , 1996, Journal of neurosurgery.

[83]  E. Moro,et al.  Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson’s disease , 1999, Neurology.

[84]  N. Quinn,et al.  Multiple system atrophy--the nature of the beast. , 1989, Journal of neurology, neurosurgery, and psychiatry.

[85]  L Lopiano,et al.  Deep brain stimulation of the subthalamic nucleus: anatomical, neurophysiological, and outcome correlations with the effects of stimulation , 2002, Journal of neurology, neurosurgery, and psychiatry.

[86]  S. Rauch,et al.  Neurosurgical treatment of Tourette's syndrome: a critical review. , 1995, Comprehensive psychiatry.

[87]  M. Robertson,et al.  Tourette syndrome, associated conditions and the complexities of treatment. , 2000, Brain : a journal of neurology.

[88]  V. Vandewalle,et al.  Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamus , 1999, The Lancet.

[89]  B. Peterson,et al.  Reduced basal ganglia volumes in Tourette's syndrome using three‐dimensional reconstruction techniques from magnetic resonance images , 1993, Neurology.

[90]  H. Stevens.  THE SYNDROME OF GILLES DE LA TOURETTE AND ITS TREATMENT: REPORT OF A CASE. , 1964, The Medical annals of the District of Columbia.

[91]  S. Fahn.  Unified Parkinson's Disease Rating Scale , 1987 .