Microwave tomography: review of the progress towards clinical applications

Microwave tomography (MWT) is an emerging biomedical imaging modality with great potential for non-invasive assessment of functional and pathological conditions of soft tissues. This paper presents a review of research results obtained by the author and his colleagues and focuses on various potential clinical applications of MWT. Most clinical applications of MWT imaging have complicated, nonlinear, high dielectric contrast inverse problems of three-dimensional diffraction tomography. There is a very high dielectric contrast between bones and fatty areas compared with soft tissues. In most cases, the contrast between soft-tissue abnormalities (the target imaging areas) is less pronounced than between bone (fat) and soft tissue. This additionally complicates the imaging problem. In spite of the difficulties mentioned, it has been demonstrated that MWT is applicable for extremities imaging, breast cancer detection, diagnostics of lung cancer, brain imaging and cardiac imaging.

[1]  Laura W. Bancroft,et al.  Imaging in Acute Stroke , 2011, The western journal of emergency medicine.

[2]  Chronic Disease Division Cancer facts and figures , 2010 .

[3]  M. Lindstrom,et al.  A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries , 2007, Physics in medicine and biology.

[4]  Serguei Semenov,et al.  Microwave tomography for functional imaging of extremity soft tissues: feasibility assessment , 2007, Physics in medicine and biology.

[5]  Ann P O'Rourke,et al.  Dielectric properties of human normal, malignant and cirrhotic liver tissue: in vivo and ex vivo measurements from 0.5 to 20 GHz using a precision open-ended coaxial probe , 2007, Physics in medicine and biology.

[6]  Adnan I. Qureshi,et al.  Guidelines for the Early Management of Adults With Ischemic Stroke , 2007 .

[7]  M. Lindstrom,et al.  A large-scale study of the ultrawideband microwave dielectric properties of normal breast tissue obtained from reduction surgeries , 2007, Physics in medicine and biology.

[8]  C Gabriel,et al.  Dielectric properties of porcine cerebrospinal tissues at microwave frequencies: in vivo, in vitro and systematic variation with age , 2007, Physics in medicine and biology.

[9]  K. Furie,et al.  Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2007, Circulation.

[10]  A. E. Bulyshev,et al.  Microwave Tomographic Imaging of the Heart in Intact Swine , 2006 .

[11]  P. Kosmas,et al.  Time reversal with the FDTD method for microwave breast cancer detection , 2005, IEEE Transactions on Microwave Theory and Techniques.

[12]  P.M. van den Berg,et al.  Microwave-tomographic imaging of the high dielectric-contrast objects using different image-reconstruction approaches , 2005, IEEE Transactions on Microwave Theory and Techniques.

[13]  Georg Neubauer,et al.  Dielectric properties of human brain tissue measured less than 10 h postmortem at frequencies from 800 to 2450 MHz , 2003, Bioelectromagnetics.

[14]  Serguei Y. Semenov,et al.  Microwave Tomography for Detection/Imaging of Myocardial Infarction. I. Excised Canine Hearts , 2003, Annals of Biomedical Engineering.

[15]  Robert H. Svenson,et al.  Dielectrical spectroscopy of canine myocardium during acute ischemia and hypoxia at frequency spectrum from 100 kHz to 6 GHz , 2002, IEEE Transactions on Medical Imaging.

[16]  Paul M. Meaney,et al.  Enhancing breast tumor detection with near-field imaging , 2002 .

[17]  Neil A. Rowson,et al.  Dielectric properties of coal , 2001 .

[18]  Robert H. Svenson,et al.  Computational modeling of three-dimensional microwave tomography of breast cancer , 2001, IEEE Transactions on Biomedical Engineering.

[19]  Elise C. Fear,et al.  Microwave detection of breast cancer , 2000 .

[20]  Paul M. Meaney,et al.  A clinical prototype for active microwave imaging of the breast , 2000 .

[21]  Robert H. Svenson,et al.  Two-dimensional computer analysis of a microwave flat antenna array for breast cancer tomography , 2000 .

[22]  Robert H. Svenson,et al.  Three-dimensional microwave tomography: experimental imaging of phantoms and biological objects , 2000 .

[23]  Robert H. Svenson,et al.  Microwave tomography: a two-dimensional Newton iterative scheme , 1998 .

[24]  R. W. Lau,et al.  The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. , 1996, Physics in medicine and biology.

[25]  M. Säbel,et al.  Recent developments in breast imaging. , 1996, Physics in medicine and biology.

[26]  Y. Chen [The change of serum alpha 1-antitrypsin level in patients with spontaneous pneumothorax]. , 1995, Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.

[27]  W. Joines,et al.  The measured electrical properties of normal and malignant human tissues from 50 to 900 MHz. , 1994, Medical physics.

[28]  Heywang-Köbrunner Sh,et al.  Nonmammographic breast imaging techniques. , 1992 .

[29]  Stuchly,et al.  Dielectric properties of breast carcinoma and the surrounding tissues , 1988, IEEE Transactions on Biomedical Engineering.

[30]  Charles Polk,et al.  CRC Handbook of Biological Effects of Electromagnetic Fields , 1986 .

[31]  K. Foster,et al.  Dielectric Properties of VX-2 Carcinoma Versus Normal Liver Tissue , 1986, IEEE Transactions on Biomedical Engineering.

[32]  D B Kopans,et al.  "Early" breast cancer detection using techniques other than mammography. , 1984, AJR. American journal of roentgenology.

[33]  S. S. Chaudhary,et al.  Dielectric properties of normal & malignant human breast tissues at radiowave & microwave frequencies. , 1984, Indian journal of biochemistry & biophysics.

[34]  D. Schaefer,et al.  Microwave power absorption differences between normal and malignant tissue. , 1980, International journal of radiation oncology, biology, physics.

[35]  H. Fricke,et al.  The Electric Capacity of Tumors of the Breast , 1926 .

[36]  F. Barnes,et al.  Handbook of biological effects of electromagnetic fields , 2007 .

[37]  Robert H. Svenson,et al.  Microwave Spectroscopy of Myocardial Ischemia and Infarction. 1. Experimental Study , 2004, Annals of Biomedical Engineering.

[38]  Robert H. Svenson,et al.  Microwave Spectroscopy of Myocardial Ischemia and Infarction. 2. Biophysical Reconstruction , 2004, Annals of Biomedical Engineering.

[39]  A. Taflove,et al.  Three-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: design of an antenna-array element , 1999 .

[40]  T Iritani,et al.  A study of the electrical bio-impedance of tumors. , 1993, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[41]  J. Kaldor,et al.  The benefits and risks of mammographic screening for breast cancer. , 1992, Epidemiologic reviews.

[42]  S H Heywang-Köbrunner,et al.  Nonmammographic breast imaging techniques. , 1992, Current opinion in radiology.

[43]  R Gordon,et al.  Detection of early breast cancer: an overview and future prospects. , 1989, Critical reviews in biomedical engineering.

[44]  U. G. Dailey Cancer,Facts and Figures about. , 2022, Journal of the National Medical Association.