Power spectrum analysis as a tool for statistical evaluation of drug effects on electrical activity of brain.

Abstract The technique of power spectrum analysis was used to study the effects of drugs on the ECoG of the cat. The statistical significance of the drug action was determined by making t-tests of the difference in power between pre-drug and post-drug spectra. The first part of the study involved chlorpromazine, diazepam and three other benzodiazepines. Chlorpromazine and Ro5-2092 increased power in the medium frequency range and decreased power in the upper range. Diazepam and Ro5-4556 increased power in both medium and upper ranges, while Ro5-6901 decreased power in these ranges. The second part of the study compared pentobarbital and methyprylon. Pentobarbital increased power in the medium range and decreased it in the upper range; there was a sharp peak in the spectrum at 7 to 8 c/s. Methyprylon differed from pentobarbital by producing no sharp peak in the frequency spectrum.

[1]  L. Goldstein,et al.  ELECTROENCEPHALOGRAPHIC ASSAY OF ANTI-ANXIETY DRUGS. , 1964, Archives of general psychiatry.

[2]  J. S. Barlow,et al.  CORRELATION ANALYSIS OF EEG CHANGES INDUCED BY UNILATERAL INTRACAROTID INJECTION OF AMOBARBITAL. , 1964, Electroencephalography and clinical neurophysiology.

[3]  H. Scheffé.  The Analysis of Variance , 1960 .

[4]  M. Brazier.  The problem of periodicity in the electroencephalogram: Studies in the cat☆ , 1963 .

[5]  W. Schallek,et al.  EFFECTS OF BENZODIAZEPINES ON SPONTANEOUS EEG AND AROUSAL RESPONSES OF CATS. , 1965, Progress in brain research.

[6]  W. R. Adey,et al.  PROLONGED EFFECTS OF LSD ON EEG RECORDS DURING DISCRIMINATIVE PERFORMANCE IN CAT; EVALUATION BY COMPUTER ANALYSIS. , 1965, Electroencephalography and clinical neurophysiology.

[7]  S. H. Bartley,et al.  ACTION OF ETHER AND NEMBUTAL ON THE NERVOUS SYSTEM , 1940 .

[8]  D. O. Walter,et al.  Spectral analysis for electroencephalograms: mathematical determination of neurophysiological relationships from records of limited duration. , 1963, Experimental neurology.

[9]  E. Eidelberg,et al.  Anticonvulsant properties of some benzodiazepine derivatives , 1965, Neurology.

[10]  P. Bradley,et al.  The effect of chlorpromazine and methopromazine on the electrical activity of the brain in the cat. , 1957, Electroencephalography and clinical neurophysiology.

[11]  F. Gibbs,et al.  Clinical and pharmacological correlates of fast activity in electroencephalography. , 1962, Journal of neuropsychiatry.

[12]  T. Lewinson,et al.  Power spectrum analysis of drug effects on electroencephalogram of cat. , 1967, International journal of neuropharmacology.

[13]  COMPUTER ANALYSIS OF DRUG EFFECTS ON THE ELECTROENCEPHALOGRAMS OF NORMAL AND PSYCHOTIC SUBJECTS. , 1964, International journal of neuropharmacology.

[14]  W. Schallek,et al.  Central depressant effects of methyprylon. , 1956, The Journal of pharmacology and experimental therapeutics.

[15]  E. Eidelberg,et al.  Spectrum analysis of electroencephalographic changes induced by some psychoactive agents. Their possible relationship to changes in cerebral biogenic amine levels. , 1966, International journal of neuropharmacology.

[16]  J. Eccles,et al.  The ventro‐basal complex of the thalamus: types of cells, their responses and their functional organization , 1964, The Journal of physiology.

[17]  L. Goldstein,et al.  Amplitude analysis of the electroencephalogram. Review of the information obtained with the integrative method. , 1965, International review of neurobiology.

[18]  C. W. Watson,et al.  Effects of barbiturates and ether on spontaneous electrical activity of dog brain. , 1949, Journal of neurophysiology.

[19]  R. Morison,et al.  THE INTERACTION OF CERTAIN SPONTANEOUS AND INDUCED CORTICAL POTENTIALS , 1941 .

[20]  T. Teichmann,et al.  The Measurement of Power Spectra , 1960 .