Prognostic signs and the management of the mycosis fungoides

A total of 132 patients with biopsy‐proven mycosis fungoides were treated by total skin irradiation with 2.5 MeV electrons. In 58% a complete remission of cutaneous manifestations was observed. The rate of complete remission was dose‐dependent and was inversely dependent on the extent of disease. Fourteen patients had disease‐free survivals of 3–14 years following a single course of treatment, and may be considered as cured. Fifty‐six patients died, 52% of whom succumbed to extracutaneous involvement with disease. Extracutaneous involvement correlated with the extent of skin involvement, and with the presence of initial lymphadenopathy, and was associated with poor prognosis. A new staging classification is proposed which provides a rational basis for the introduction of new treatment modalities for the management of mycosis fungoides patients.

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