How to treat lumbar disc herniation in pregnancy? A systematic review on current standards

PurposeIn this systematic review, we aim to illustrate the current and safe concepts in the assessment, diagnosis and management of herniated lumbar disc (HLD) during pregnancy.MethodsA systematic review and reporting on the diagnosis, treatment and clinical results of HLD during pregnancy is performed.ResultsThe MRI represents the first level and safest diagnostic tool for pregnant women affected by spinal problems allowing for a noninvasive and detailed radiological examination of the spine. The initial management of pregnant women affected by HLD is conservative, and primarily aimed to pain therapy. Whenever radicular pain and progressive neurological deficits unresponsive to medical management occur, surgery should be considered. Few case reports regarding the operative management of HLD in pregnant women have been published up to date. Laminectomy and/or microdiscectomy represent the classical and most commonly used techniques that can be safely performed without affecting pregnancy, delivery, or baby’s health. Endoscopic discectomy may be an alternative. The most adequate timing and surgical position are chosen based on to the fetal gestational age and site of the pathology.ConclusionsSurgical treatments during pregnancy impose multiple medical and ethical problems. Timely diagnosis by MRI, careful clinical evaluation, and surgical treatment represent safe and effective procedures. Ongoing evolution of surgical, anesthesiological and obstetrical procedures results in favorable outcomes. However, interdisciplinary management and a wide knowledge of pregnancy-related pathologies are crucial for the best outcome for both mother and child.

[1]  A. Cavaliere,et al.  Ionizing radiations in pregnancy and teratogenesis: a review of literature. , 2005, Reproductive toxicology.

[2]  S. Singh,et al.  Case report: Anesthetic management for sequential Cesarean delivery and laminectomy , 2007, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[3]  P. Kristiansson,et al.  Corticosteroid Injection Treatment to the Ischiadic Spine Reduced Pain in Women With Long-Lasting Sacral Low Back Pain With Onset During Pregnancy: A Randomized, Double Blind, Controlled Trial , 2009, Spine.

[4]  M. Parnianpour,et al.  Pregnancy Related Pelvic Girdle Pain and Low Back Pain in an Iranian Population , 2007, Spine.

[5]  H. Kim,et al.  Endoscopic discectomy for the cauda equina syndrome during third trimester of pregnancy. , 2007, Journal of Korean Neurosurgical Society.

[6]  L. Ugga,et al.  Imaging of post-surgical treatment and of related complications in spinal trauma , 2017, MUSCULOSKELETAL SURGERY.

[7]  P. Barash,et al.  Fetal heart rate monitoring in pregnant patients undergoing surgery. , 1976, American journal of obstetrics and gynecology.

[8]  K. Svärdsudd,et al.  Serum relaxin, symphyseal pain, and back pain during pregnancy. , 1996, American journal of obstetrics and gynecology.

[9]  D. Thomas,et al.  Prognosis for sphincter recovery after operation for cauda equina compression owing to lumbar disc prolapse. , 1981, British medical journal.

[10]  Colleen G Martel,et al.  Anesthetic Management of the Parturient for Lumbar Disc Surgery in the Prone Position. , 2015, The Ochsner journal.

[11]  M. LaBan,et al.  Pregnancy and the herniated lumbar disc. , 1983, Archives of physical medicine and rehabilitation.

[12]  Pragya Gupta,et al.  Acute presentation of cauda equina syndrome in the third trimester of pregnancy. , 2008, European journal of obstetrics, gynecology, and reproductive biology.

[13]  B. Stuge,et al.  European guidelines for the diagnosis and treatment of pelvic girdle pain , 2008, European Spine Journal.

[14]  A. Gutke,et al.  Predicting Persistent Pregnancy-Related Low Back Pain , 2008, Spine.

[15]  S. Hasson,et al.  Low back pain during pregnancy in Iranian women: Prevalence and risk factors , 2010, Physiotherapy theory and practice.

[16]  A. Tyagi,et al.  A Case of Delayed Diagnosis of the Cauda Equina Syndrome in Pregnancy , 1999, The Australian & New Zealand journal of obstetrics & gynaecology.

[17]  E. Amento,et al.  Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts. , 1990, The Journal of biological chemistry.

[18]  J. O'connell LUMBAR DISC PROTRUSIONS IN PREGNANCY , 1960, Journal of neurology, neurosurgery, and psychiatry.

[19]  M. Childers,et al.  Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial , 2005, Current medical research and opinion.

[20]  H. Stam,et al.  Understanding Peripartum Pelvic Pain: Implications of a Patient Survey , 1996, Spine.

[21]  A. Mclaren,et al.  Lumbar discectomy in pregnancy , 2006, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[22]  L. Blais,et al.  Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study. , 2006, Birth defects research. Part B, Developmental and reproductive toxicology.

[23]  D. Abramson Relaxation of the pelvic joints in pregnancy , 1934 .

[24]  J. Viale,et al.  Prostaglandin F2α: French guidelines for uterine atony management , 2006 .

[25]  M. D'alton,et al.  LUMBAR DISK DISEASE IN PREGNANCY , 1997, Obstetrics and gynecology.

[26]  C. Schauberger,et al.  Peripheral joint laxity increases in pregnancy but does not correlate with serum relaxin levels. , 1996, American journal of obstetrics and gynecology.

[27]  内田隆一,et al.  小児急性嘔吐下痢症に対する五苓散の効果:バングラデシュにおけるRandomized,Double‐blind,Controlled Trial , 2012 .

[28]  J. Dashe,et al.  Antibiotic use in pregnancy. , 1997, Obstetrics and gynecology clinics of North America.

[29]  McIntyre In,et al.  Effective treatment of low back pain in pregnancy. , 1996 .

[30]  I. McIntyre,et al.  Effective treatment of low back pain in pregnancy. , 1996, Australian family physician.

[31]  G. Pardi,et al.  Undesired effects of steroids during pregnancy. , 2004, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[32]  A. Khalilian,et al.  Low back pain in 1,100 Iranian pregnant women: prevalence and risk factors. , 2009, The spine journal : official journal of the North American Spine Society.

[33]  Laban Mm,et al.  Pregnancy and the herniated lumbar disc , 1983 .

[34]  J. Weinreb,et al.  Prevalence of lumbosacral intervertebral disk abnormalities on MR images in pregnant and asymptomatic nonpregnant women. , 1989, Radiology.

[35]  JOSEPH R. RITCHIE,et al.  Orthopedic Considerations During Pregnancy , 2003, Clinical obstetrics and gynecology.

[36]  T. Dinning,et al.  Discogenic compression of the cauda equina: a surgical emergency. , 1993, The Australian and New Zealand journal of surgery.

[37]  M. Çelik,et al.  Anesthetic management of lumbar discectomy in a pregnant patient , 2003, Journal of Anesthesia.

[38]  E. Kanal,et al.  Infertility and pregnancy outcome among magnetic resonance imaging workers. , 1993, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[39]  K. Ashkan,et al.  Back Pain during Pregnancy and after Childbirth: An Unusual Cause not to Miss , 1998, Journal of the Royal Society of Medicine.

[40]  Spankus Jd The cause and treatment of low back pain during pregnancy. , 1965 .

[41]  C. Haas,et al.  Surgical Management of the Pregnant Patient With Lumbar Disc Herniation in the Latter Stage of the Second Trimester , 2017, Spine.

[42]  M. Grevitt,et al.  Lumbar disc surgery in the third trimester--with the fetus in utero. , 2006, International journal of obstetric anesthesia.

[43]  Gunilla Zetherström,et al.  Regression of Back and Posterior Pelvic Pain After Pregnancy , 1996, Spine.

[44]  D. Atar,et al.  Cauda Equina Syndrome in a 36 Week Gravida Patient. , 2015, The Israel Medical Association journal : IMAJ.

[45]  T. Hakan Lumbar disk herniation presented with cauda equina syndrome in a pregnant woman , 2012, Journal of neurosciences in rural practice.

[46]  K. Brookfield,et al.  Lumbar disc excision and cesarean delivery during the same anesthesia. A case report. , 2004, The Journal of bone and joint surgery. American volume.

[47]  O. G. Meijer,et al.  Pregnancy-related pelvic girdle pain (PPP), I: Terminology, clinical presentation, and prevalence , 2004, European Spine Journal.

[48]  K. An,et al.  Characterization of the Relationship Between Joint Laxity and Maternal Hormones in Pregnancy , 2003, Obstetrics and gynecology.

[49]  J. Kostuik,et al.  Cauda equina syndrome and lumbar disc herniation. , 1986, The Journal of bone and joint surgery. American volume.

[50]  M. Betsch,et al.  Spinal posture and pelvic position during pregnancy: a prospective rasterstereographic pilot study , 2015, European Spine Journal.

[51]  M. Tatagiba,et al.  Neurosurgical interventions during pregnancy and the puerperium: clinical considerations and management , 2004, Acta Neurochirurgica.

[52]  P. Fonio,et al.  Imaging of post-operative spine in intervertebral disc pathology , 2017, MUSCULOSKELETAL SURGERY.

[53]  P. Chacha,et al.  Midline prolapse of a lumbar intervertebral disc with compression of the cauda equina. , 1979, The Journal of bone and joint surgery. British volume.

[54]  P. Middleton,et al.  Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes. , 2011, The Cochrane database of systematic reviews.

[55]  I. Han,et al.  Clinical Approach and Surgical Strategy for Spinal Diseases in Pregnant Women: A Report of Ten Cases , 2008, Spine.

[56]  D. Findlay,et al.  Surgical management of herniated lumbar disc in pregnancy. , 1998, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.

[57]  H. Currey,et al.  Backache in pregnancy. , 1977, Rheumatology and rehabilitation.

[58]  G. Andersson,et al.  The impact of low back and pelvic pain in pregnancy on the pregnancy outcome , 1991, Acta obstetricia et gynecologica Scandinavica.

[59]  A. Levi,et al.  Surgery for Lumbar Disc Herniation During Pregnancy , 2001, Spine.

[60]  M. LaBan,et al.  The lumbar herniated disk of pregnancy: a report of six cases identified by magnetic resonance imaging. , 1995, Archives of physical medicine and rehabilitation.