Cerebellar Cortex: Computation by Extrasynaptic Inhibition?

In the cerebellar cortex, inhibitory inputs to granule cells exhibit prominent tonic and spillover components resulting from the activation of extrasynaptic receptors. A recent study shows how extrasynaptic inhibition affects information flow through cerebellar cortex.

[1]  Peter Somogyi,et al.  Segregation of Different GABAA Receptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells , 1998, The Journal of Neuroscience.

[2]  Christof Koch,et al.  Shunting Inhibition Does Not Have a Divisive Effect on Firing Rates , 1997, Neural Computation.

[3]  G. Sperk,et al.  GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. , 2000, Neuroscience.

[4]  R. Angus Silver,et al.  GABA Spillover from Single Inhibitory Axons Suppresses Low-Frequency Excitatory Transmission at the Cerebellar Glomerulus , 2000, The Journal of Neuroscience.

[5]  E. De Schutter,et al.  Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer. , 1998, Journal of neurophysiology.

[6]  E. Cherubini,et al.  Generating diversity at GABAergic synapses. , 2001, Trends in neurosciences.

[7]  E. D’Angelo,et al.  Evidence for NMDA and mGlu receptor-dependent long-term potentiation of mossy fiber-granule cell transmission in rat cerebellum. , 1999, Journal of neurophysiology.

[8]  J. Albus A Theory of Cerebellar Function , 1971 .

[9]  D. Rossi,et al.  Spillover-Mediated Transmission at Inhibitory Synapses Promoted by High Affinity α6 Subunit GABAA Receptors and Glomerular Geometry , 1998, Neuron.

[10]  E De Schutter,et al.  The function of cerebellar Golgi cells revisited. , 2000, Progress in brain research.

[11]  G M Rose,et al.  Exposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus In Vitro , 1999, The Journal of Neuroscience.

[12]  E De Schutter,et al.  Cerebellar Golgi cells in the rat: receptive fields and timing of responses to facial stimulation , 1999, The European journal of neuroscience.

[13]  S. Dieudonné,et al.  Submillisecond kinetics and low efficacy of parallel fibre‐Golgi cell synaptic currents in the rat cerebellum , 1998, The Journal of physiology.

[14]  S. Cull-Candy,et al.  Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors. , 1996, The Journal of physiology.

[15]  Mark J. Wall,et al.  Development of Action Potential‐dependent and Independent Spontaneous GABAA Receptor‐mediated Currents in Granule Cells of Postnatal Rat Cerebellum , 1997, The European journal of neuroscience.

[16]  G. Sperk,et al.  GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain , 2000, Neuroscience.

[17]  William Wisden,et al.  Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance , 2001, Nature.

[18]  D. Marr A theory of cerebellar cortex , 1969, The Journal of physiology.

[19]  E. Cherubini,et al.  Generating diversity at GAB Aergic synapses , 2001, Trends in Neurosciences.

[20]  Reinoud Maex,et al.  Weak common parallel fibre synapses explain the loose synchrony observed between rat cerebellar Golgi cells , 2000, The Journal of physiology.

[21]  David Attwell,et al.  Tonic and Spillover Inhibition of Granule Cells Control Information Flow through Cerebellar Cortex , 2002, Neuron.

[22]  R. Macdonald,et al.  Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms. , 1996, Molecular pharmacology.

[23]  Erik De Schutter,et al.  Parallel Fibers Synchronize Spontaneous Activity in Cerebellar Golgi Cells , 1999, The Journal of Neuroscience.