Relationship Between Emotional Behavior in Mice and the Concentration of (+)‐α‐Santalol in the Brain

We previously reported finding anxiolytic‐like activity for sandalwood oil after administration in mice. In this report, we further investigated the emotional behavior associated with inhaled or intraperitoneally administered (+)‐α‐santalol, the main component of sandalwood oil, in addition to examining whether pharmacological or neurological transfers are responsible for this behavior. After administration of (+)‐α‐santalol by inhalation or intraperitoneal injection, we assessed anxiolytic‐like and locomotor activities using elevated‐plus maze tests. We also examined the relationship between the emotional behavior and the (+)‐α‐santalol brain concentration.

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