Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10−7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10−11; combined RR = 1.25; combined P = 1.8 × 10−15).

Eric Boerwinkle | Vilmundur Gudnason | Thomas Lumley | Lenore J. Launer | Joshua C. Bis | Nicholas L. Smith | Kenneth M. Rice | Fernando Rivadeneira | Ralph B. D’Agostino | Man Li | Tamara B. Harris | Albert Hofman | Cornelia M. van Duijn | Aravinda Chakravarti | Patrick T. Ellinor | Steven A. Lubitz | Daniel Levy | Kathryn L. Lunetta | Jerome I. Rotter | Abbas Dehghan | Arne Pfeufer | Georg B. Ehret | Martin G. Larson | Alanna M. Chamberlain | Bruce M. Psaty | Andre G. Uitterlinden | Gudny Eiriksdottir | Thor Aspelund | Sunil K. Agarwal | Emelia J. Benjamin | Jan Heeringa | Renate B. Schnabel | Susan R. Heckbert | K. Lunetta | A. Hofman | A. Uitterlinden | D. Levy | T. Lumley | E. Boerwinkle | R. D'Agostino | P. Wolf | V. Gudnason | E. Benjamin | R. Schnabel | P. Ellinor | R. Vasan | A. Chakravarti | A. Dehghan | F. Rivadeneira | J. Witteman | T. Meitinger | Thomas J. Wang | B. Psaty | D. Arking | C. Noord | C. Newton-Cheh | J. Rotter | A. Pfeufer | T. Harris | N. Sotoodehnia | K. Rice | C. V. van Duijn | E. Soliman | G. Steinbeck | J. Bis | M. Larson | G. Eiriksdottir | L. Launer | T. Aspelund | S. Heckbert | S. Perz | G. Ehret | Man Li | C. Duijn | W. Kao | S. Lubitz | A. Chamberlain | B. Stricker | S. Kääb | K. Marciante | Á. Alonso | N. Smith | Moritz F. Sinner | J. Heeringa | S. Kaab | H. Wichmann | Philip A Wolf | Christopher Newton-Cheh | Ramachandran S. Vasan | Nona Sotoodehnia | Alvaro Alonso | C. van Noord | S. Agarwal | Charlotte van Noord | Dan E. Arking | Jacqueline C. Witteman | Albert V. Smith | Elsayed Z. Soliman | Anna Kottgen | Stefan Kaab | Kristin D. Marciante | W.H. Linda Kao | Ke Wang | Bruno H. Ch. Stricker | Ke Wang | A. Smith | A. Kottgen | W. Kao | A. Smith | Anna Köttgen | A. Uitterlinden | A. Hofman | B. Psaty | Martina Mueller | A. Köttgen | Á. Alonso | D. Levy | C. Newton‐Cheh | Á. Alonso

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