Early‐Life Programming of Aging and Longevity: The Idea of High Initial Damage Load (the HIDL Hypothesis)

Abstract: In this study, we test the predictions of the high initial damage load (HIDL) hypothesis, a scientific idea that early development of living organisms produces an exceptionally high load of initial damage, which is comparable with the amount of subsequent aging‐related deterioration accumulating during the rest of the entire adult life. This hypothesis predicts that even small progress in optimizing the early‐developmental processes can potentially result in a remarkable prevention of many diseases in later life, postponement of aging‐related morbidity and mortality, and significant extension of healthy life span.

[1]  S. J. Olshansky,et al.  The Biology of Life Span: A Quantitative Approach. , 1992 .

[2]  L. Gavrilov,et al.  The quest for a general theory of aging and longevity. , 2003, Science of aging knowledge environment : SAGE KE.

[3]  L. Gavrilov,et al.  The biology of life span: A quantitative approach: Revised and updated English edition. Originally published in Russian by Nauka, Moscow, 1986. Translated into English by John and Liliya Payne. 385 pp., 1991. Price: $40.00 US , 1992 .

[4]  D. Harman,et al.  Free radical theory of aging: Beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring; possible explanation of the sex difference in longevity , 1979, AGE.

[5]  L. Gavrilov,et al.  The reliability theory of aging and longevity. , 2001, Journal of theoretical biology.

[6]  B. Gompertz,et al.  On the Nature of the Function Expressive of the Law of Human Mortality , 1825 .

[7]  Benjamin Gompertz,et al.  XXIV. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. In a letter to Francis Baily, Esq. F. R. S. &c , 1825, Philosophical Transactions of the Royal Society of London.

[8]  Leonid A. Gavrilov,et al.  Early-life factors modulating lifespan. , 2003 .

[9]  L. Gavrilov,et al.  When Does Human Longevity Start?: Demarcation of the Boundaries for Human Longevity , 2001 .

[10]  H. Grüneberg,et al.  Introduction to quantitative genetics , 1960 .

[11]  L. Gavrilov,et al.  Season of Birth and Human Longevity , 1999 .

[12]  W. Weibull.  A Statistical Distribution Function of Wide Applicability , 1951 .