Effect of Autoimmune Cell Therapy on Immune Cell Content in Patients with COPD: A Randomized Controlled Trial

Objective To explore the effect of autoimmune cell therapy on immune cells in patients with chronic obstructive pulmonary disease (COPD) and to provide a reference for clinical treatment of COPD. Methods Sixty patients with stable COPD were randomly divided into control group and treatment group (n = 30). The control group was given conventional treatment, and the treatment group was given one autoimmune cell therapy on the basis of conventional treatment. The serum levels of CD3+ T cells, CD4+ T cells, CD8+ cells, B cells, and NK cells in the peripheral blood were detected by flow cytometry. Possible adverse reactions were detected at any time during treatment. Results There were no significant differences in the contents of CD3+ T cells, CD4+ T cells, CD8+ cells, B cells, and NK cells in the serum of the control group (P > 0.05). Compared with before treatment, the contents of CD3+ T cells, CD4+ T cells, CD8+ cells, B cells, and NK cells in the serum of the treatment group were significantly increased (P < 0.05). The ratio of CD4 + /CD8+ T cells in both control and treatment groups did not change significantly during treatment (P > 0.05). There were no significant differences in serum CD3+ T cells, CD4+ T cells, CD8+ cells, B cells, and NK cells in the treatment group at 30 days and 90 days after treatment (P > 0.05), but they were significantly higher than those in the control group (P < 0.05). Conclusion Autoimmune cell therapy can significantly increase the level of immune cells in the body and can be maintained for a long period of time, which has certain clinical benefits for recurrent respiratory tract infections and acute exacerbation in patients with COPD.

[1]  D. Mannino,et al.  Burden and pathogenesis of chronic obstructive pulmonary disease. , 2009, Proceedings of the American Thoracic Society.

[2]  S. Ohlmeier,et al.  Distribution and levels of alpha‐1‐antitrypsin in the lung and plasma in smokers and chronic obstructive pulmonary disease , 2013, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[3]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[4]  S. Hodge,et al.  Increased CD8 T‐cell granzyme B in COPD is suppressed by treatment with low‐dose azithromycin , 2015, Respirology.

[5]  P. Alam.  ‘A’ , 2021, Composites Engineering: An A–Z Guide.

[6]  M. Cosio,et al.  Chronic smoke exposure induces rheumatoid factor and anti‐heat shock protein 70 autoantibodies in susceptible mice and humans with lung disease , 2012, European journal of immunology.

[7]  Matthew Collin,et al.  Human dendritic cell subsets: an update , 2018, Immunology.

[8]  Mei Han,et al.  Effect of acupoint application on T lymphocyte subsets in patients with chronic obstructive pulmonary disease , 2020, Medicine.

[9]  M. Montero,et al.  Differential lymphocyte infiltration in small airways and lung parenchyma in COPD patients. , 2010, Respiratory medicine.

[10]  Tsuyoshi Murata,et al.  {m , 1934, ACML.

[11]  J. Ilonen,et al.  Low CD4/CD8 T lymphocyte ratio in acute myocardial infarction , 1991, Clinical and experimental immunology.

[12]  L. Fairclough,et al.  The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review , 2020, Inflammation research : official journal of the European Histamine Research Society ... [et al.].

[13]  M. Borchers,et al.  Functional Characterization of T Cell Populations in a Mouse Model of Chronic Obstructive Pulmonary Disease , 2013, The Journal of Immunology.

[14]  H. Lyerly,et al.  DC-CIK as a widely applicable cancer immunotherapy , 2020, Expert opinion on biological therapy.

[15]  장윤희,et al.  Y. , 2003, Industrial and Labor Relations Terms.

[16]  W. Marsden.  I and J , 2012 .

[17]  W. Hager,et al.  and s , 2019, Shallow Water Hydraulics.

[18]  Manxiang Li,et al.  Comparative Study of Cytokine Levels in Different Respiratory Samples in Mild-to-Moderate AECOPD Patients , 2019, Lung.

[19]  P. Alam.  ‘Z’ , 2021, Composites Engineering: An A–Z Guide.

[20]  Meilan K. Han,et al.  Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood , 2015, Respiratory Research.

[21]  P. Alam.  ‘N’ , 2021, Composites Engineering: An A–Z Guide.

[22]  Peter Bader,et al.  Selection and expansion of natural killer cells for NK cell-based immunotherapy , 2016, Cancer Immunology, Immunotherapy.

[23]  B. Goldman,et al.  The cancer vaccine roller coaster , 2009, Nature Biotechnology.

[24]  I. Adcock,et al.  Corticosteroid modulation of immunoglobulin expression and B‐cell function in COPD , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  M. Stämpfli,et al.  Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke , 2008, Journal of leukocyte biology.

[26]  P. Alam,et al.  H , 1887, High Explosives, Propellants, Pyrotechnics.

[27]  P. Alam.  ‘K’ , 2021, Composites Engineering.

[28]  S. Szefler,et al.  Inhaled corticosteroids in lung diseases. , 2013, American journal of respiratory and critical care medicine.

[29]  Yao Wang,et al.  Repeated transfusions of autologous cytokine‐induced killer cells for treatment of haematological malignancies in elderly patients: a pilot clinical trial , 2012, Hematological oncology.

[30]  D. Postma,et al.  Chronic obstructive pulmonary disease. , 2002, Clinical evidence.

[31]  F. Martinez,et al.  Global Initiative for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease. The 2020 GOLD Science Committee Report on COVID-19 and Chronic Obstructive Pulmonary Disease , 2020, American journal of respiratory and critical care medicine.

[32]  P. Alam,et al.  R , 1823, The Herodotus Encyclopedia.

[33]  P. Alam.  ‘E’ , 2021, Composites Engineering: An A–Z Guide.

[34]  R. Levy,et al.  Axicabtagene Ciloleucel CAR T‐Cell Therapy in Refractory Large B‐Cell Lymphoma , 2017, The New England journal of medicine.

[35]  S. Verleden,et al.  The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease , 2019, EBioMedicine.

[36]  P. Kantoff,et al.  Sipuleucel-T immunotherapy for castration-resistant prostate cancer. , 2010, The New England journal of medicine.

[37]  Gorjan Alagic,et al.  #p , 2019, Quantum information & computation.

[38]  A. Woźniak,et al.  Activity of α 1-Antitrypsin and Some Lysosomal Enzymes in the Blood Serum of Patients with Chronic Obstructive Pulmonary Disease after Smoking Cessation , 2015, BioMed research international.

[39]  Fanjuan Meng,et al.  Cell-based immunotherapy with cytokine-induced killer (CIK) cells: From preparation and testing to clinical application , 2017, Human vaccines & immunotherapeutics.

[40]  J. Izquierdo,et al.  Defective natural killer and phagocytic activities in chronic obstructive pulmonary disease are restored by glycophosphopeptical (inmunoferón). , 2001, American journal of respiratory and critical care medicine.

[41]  D. Duncan.  Chronic obstructive pulmonary disease: an overview. , 2016, British journal of nursing.

[42]  J. Ryu,et al.  Treatment of acute exacerbations of interstitial lung disease , 2018, Expert review of respiratory medicine.

[43]  Yanfang Jiang,et al.  Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease , 2013, Clinical & developmental immunology.

[44]  Zhen-hua Li,et al.  Circulating miR-146a/b correlates with inflammatory cytokines in COPD and could predict the risk of acute exacerbation COPD , 2018, Medicine.

[45]  P. Alam.  ‘T’ , 2021, Composites Engineering: An A–Z Guide.

[46]  R. Sarpong,et al.  Bio-inspired synthesis of xishacorenes A, B, and C, and a new congener from fuscol† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02572c , 2019, Chemical science.

[47]  J. Wedzicha,et al.  Definition, Causes, Pathogenesis, and Consequences of Chronic Obstructive Pulmonary Disease Exacerbations , 2020, Clinics in Chest Medicine.

[48]  P. Barnes.  Cellular and molecular mechanisms of asthma and COPD. , 2017, Clinical science.