Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa

The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity. Bioassay-guided isolation of this extract yielded ethyl caffeate ( 1 ), rosmarinic acid ( 2 ) and methyl rosmarinate ( 3 ), which inhibited ACE activity by 32.42%, 55.19% and 39.50% respectively, at the concentration of 10 m g/ml. r 2007 Elsevier GmbH. All rights reserved.

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